ATP-induced IL-1β specific secretion: true under stringent conditions.

ATP-induced IL-1β specific secretion: true under stringent conditions.

Interleukin-1β is a potent proinflammatory cytokine, of which processing and secretion are tightly regulated. After exposure to various stimuli, mononuclear phagocytes synthesize the inactive precursor (pro-IL-1β), which is then cleaved intracellularly by caspase-1 and secreted. A widely used method...

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Bibliographic Details
Main Authors: Monique eStoffels, Ruben eZaal, Nina eKok, Jos W.M. van der Meer, Charles A. Dinarello, Anna eSimon
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Immunology
Subjects:
Cell Death
Interleukin-1
ATP
active secretion
stringent experimental conditions.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00054/full

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