Nasopharyngeal carcinoma in Ibadan, Nigeria: a clinicopathologic study
INTRODUCTION: nasopharyngeal carcinoma is relatively common in our environment. It is one of the most difficult malignancies to diagnose at an early stage. The aim of the study was to determine the clinical features, clinical disease stage of nasopharyngeal carcinoma at presentation and at diagnosis...
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The Pan African Medical Journal
2020-06-01
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| Series: | The Pan African Medical Journal |
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https://www.panafrican-med-journal.com/content/article/36/82/pdf/82.pdf
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| author | Gabriel Olabiyi Ogun Aralola Adepeju Olusanya Victor Ifeolu Akinmoladun Adebolajo Adewunmi Adeyemo Segun Ayodeji Ogunkeyede Adekunle Daniel Babatope Lanre Awosusi Ebenezer Oluwaseun Fatunla Ayotunde James Fasunla Paul Adekunle Onakoya Aderemi Adeleke Adeosun Onyekwere George Nwaorgu |
| author_facet | Gabriel Olabiyi Ogun Aralola Adepeju Olusanya Victor Ifeolu Akinmoladun Adebolajo Adewunmi Adeyemo Segun Ayodeji Ogunkeyede Adekunle Daniel Babatope Lanre Awosusi Ebenezer Oluwaseun Fatunla Ayotunde James Fasunla Paul Adekunle Onakoya Aderemi Adeleke Adeosun Onyekwere George Nwaorgu |
| author_sort | Gabriel Olabiyi Ogun |
| collection | DOAJ |
| description | INTRODUCTION: nasopharyngeal carcinoma is relatively common in our environment. It is one of the most difficult malignancies to diagnose at an early stage. The aim of the study was to determine the clinical features, clinical disease stage of nasopharyngeal carcinoma at presentation and at diagnosis as well as the histologic types at the University College Hospital, Ibadan, Nigeria. METHODS: this was a ten year retrospective study of all histologically confirmed nasopharyngeal carcinoma between January 2007 to December 2016 using clinical and pathology records and files. RESULTS: there were 73 cases. The male: female ratio was 1.7. The age of patients ranged from 12 to 80 years with a mean age of 39 ± 16 years. The median age at diagnosis was 40 years. The peak age group of occurrence was 40-49 years. The most common symptoms were namely epistaxis in 67.1% of patients at presentation, neck mass/swelling (64.4%) and nasal mass/obstruction (63.0%). Majority (54.8%) of the patients presented late with stage 3 or 4 disease. Most (94.5%) of the tumours were of the non-keratinizing squamous cell carcinoma subtype. The keratinizing and basaloid variants accounted for 4.1% and 1.4% of the tumours respectively. CONCLUSION: vague, non-specific symptoms make patients present at late stages of the disease, makings it almost impossible to attempt cure. The dominant histopathological type is non-keratinizing squamous cell carcinoma and resembles that seen in most parts of Nigeria and endemic areas of the world. |
| first_indexed | 2024-12-19T22:39:43Z |
| format | Article |
| id | doaj.art-26ada48097f347fd834a98a7a00a100a |
| institution | Directory Open Access Journal |
| issn | 1937-8688 1937-8688 |
| language | English |
| last_indexed | 2024-12-19T22:39:43Z |
| publishDate | 2020-06-01 |
| publisher | The Pan African Medical Journal |
| record_format | Article |
| series | The Pan African Medical Journal |
| spelling | doaj.art-26ada48097f347fd834a98a7a00a100a2022-12-21T20:03:07ZengThe Pan African Medical JournalThe Pan African Medical Journal1937-86881937-86882020-06-01368210.11604/pamj.2020.36.82.1965719657Nasopharyngeal carcinoma in Ibadan, Nigeria: a clinicopathologic studyGabriel Olabiyi Ogun0Aralola Adepeju Olusanya1Victor Ifeolu Akinmoladun2Adebolajo Adewunmi Adeyemo3Segun Ayodeji Ogunkeyede4Adekunle Daniel5Babatope Lanre Awosusi6Ebenezer Oluwaseun Fatunla7Ayotunde James Fasunla8Paul Adekunle Onakoya9Aderemi Adeleke Adeosun10Onyekwere George Nwaorgu11 Department of Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria Department of Pathology, University College Hospital, Ibadan, Nigeria Department of Oral and Maxillofacial Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria Institute of Child Health, College of Medicine, University of Ibadan, Ibadan, Nigeria Department of Otorhinolaryngology, University College Hospital, Ibadan, Nigeria Department of Otorhinolaryngology, University College Hospital, Ibadan, Nigeria Department of Pathology, University College Hospital, Ibadan, Nigeria Department of Pathology, University College Hospital, Ibadan, Nigeria Department of Otorhinolaryngology, University College Hospital, Ibadan, Nigeria Department of Otorhinolaryngology, University College Hospital, Ibadan, Nigeria Department of Otorhinolaryngology, University College Hospital, Ibadan, Nigeria Department of Otorhinolaryngology, University College Hospital, Ibadan, Nigeria INTRODUCTION: nasopharyngeal carcinoma is relatively common in our environment. It is one of the most difficult malignancies to diagnose at an early stage. The aim of the study was to determine the clinical features, clinical disease stage of nasopharyngeal carcinoma at presentation and at diagnosis as well as the histologic types at the University College Hospital, Ibadan, Nigeria. METHODS: this was a ten year retrospective study of all histologically confirmed nasopharyngeal carcinoma between January 2007 to December 2016 using clinical and pathology records and files. RESULTS: there were 73 cases. The male: female ratio was 1.7. The age of patients ranged from 12 to 80 years with a mean age of 39 ± 16 years. The median age at diagnosis was 40 years. The peak age group of occurrence was 40-49 years. The most common symptoms were namely epistaxis in 67.1% of patients at presentation, neck mass/swelling (64.4%) and nasal mass/obstruction (63.0%). Majority (54.8%) of the patients presented late with stage 3 or 4 disease. Most (94.5%) of the tumours were of the non-keratinizing squamous cell carcinoma subtype. The keratinizing and basaloid variants accounted for 4.1% and 1.4% of the tumours respectively. CONCLUSION: vague, non-specific symptoms make patients present at late stages of the disease, makings it almost impossible to attempt cure. The dominant histopathological type is non-keratinizing squamous cell carcinoma and resembles that seen in most parts of Nigeria and endemic areas of the world. https://www.panafrican-med-journal.com/content/article/36/82/pdf/82.pdf nasopharyngeal carcinomaibadannigeriaclinical featureshistopathologynasopharynxcarcinoma |
| spellingShingle | Gabriel Olabiyi Ogun Aralola Adepeju Olusanya Victor Ifeolu Akinmoladun Adebolajo Adewunmi Adeyemo Segun Ayodeji Ogunkeyede Adekunle Daniel Babatope Lanre Awosusi Ebenezer Oluwaseun Fatunla Ayotunde James Fasunla Paul Adekunle Onakoya Aderemi Adeleke Adeosun Onyekwere George Nwaorgu Nasopharyngeal carcinoma in Ibadan, Nigeria: a clinicopathologic study The Pan African Medical Journal nasopharyngeal carcinoma ibadan nigeria clinical features histopathology nasopharynx carcinoma |
| title | Nasopharyngeal carcinoma in Ibadan, Nigeria: a clinicopathologic study |
| title_full | Nasopharyngeal carcinoma in Ibadan, Nigeria: a clinicopathologic study |
| title_fullStr | Nasopharyngeal carcinoma in Ibadan, Nigeria: a clinicopathologic study |
| title_full_unstemmed | Nasopharyngeal carcinoma in Ibadan, Nigeria: a clinicopathologic study |
| title_short | Nasopharyngeal carcinoma in Ibadan, Nigeria: a clinicopathologic study |
| title_sort | nasopharyngeal carcinoma in ibadan nigeria a clinicopathologic study |
| topic | nasopharyngeal carcinoma ibadan nigeria clinical features histopathology nasopharynx carcinoma |
| url |
https://www.panafrican-med-journal.com/content/article/36/82/pdf/82.pdf
|
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