LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) distinctly regulate neutrophil extravasation through hotspots I and II
Immune response: White blood cells follow the leader In response to infection or tissue damage, white blood cells known as leukocytes exit blood vessels at specific sites, “hotspots.” Many leukocytes follow each other out through the same hotspot. As part of the body’s initial response to infection...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-04-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-019-0227-1 |
| _version_ | 1818875611581513728 |
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| author | Young-Min Hyun Young Ho Choe Sang A. Park Minsoo Kim |
| author_facet | Young-Min Hyun Young Ho Choe Sang A. Park Minsoo Kim |
| author_sort | Young-Min Hyun |
| collection | DOAJ |
| description | Immune response: White blood cells follow the leader In response to infection or tissue damage, white blood cells known as leukocytes exit blood vessels at specific sites, “hotspots.” Many leukocytes follow each other out through the same hotspot. As part of the body’s initial response to infection or tissue damage, leukocytes are carried to infected or damaged tissues by blood vessels. To fight infection, they must exit the vessels, but how they exited was poorly understood. Young-Min Hyun at the Yonsei University College of Medicine in Seoul, South Korea and co-workers used advanced imaging techniques to visualize leukocyte delivery. They found that many leukocytes use a single hotspot to enter the blood vessel wall, travel through the wall’s interior, and then exit the wall at another hotspot. Using hotspots is thought to minimize the number of perforations in the vessel wall, maintaining vessel integrity. These results illuminate a key aspect of how efficiently the body fights infection from the viewpoint of leukocyte migration. |
| first_indexed | 2024-12-19T13:29:15Z |
| format | Article |
| id | doaj.art-26ae1f6695c34cba864210543e2d1c4e |
| institution | Directory Open Access Journal |
| issn | 1226-3613 2092-6413 |
| language | English |
| last_indexed | 2024-12-19T13:29:15Z |
| publishDate | 2019-04-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-26ae1f6695c34cba864210543e2d1c4e2022-12-21T20:19:28ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132019-04-0151411310.1038/s12276-019-0227-1LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) distinctly regulate neutrophil extravasation through hotspots I and IIYoung-Min Hyun0Young Ho Choe1Sang A. Park2Minsoo Kim3Department of Anatomy, Yonsei University College of MedicineDepartment of Anatomy, Yonsei University College of MedicineDepartment of Anatomy, Yonsei University College of MedicineDepartment of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of RochesterImmune response: White blood cells follow the leader In response to infection or tissue damage, white blood cells known as leukocytes exit blood vessels at specific sites, “hotspots.” Many leukocytes follow each other out through the same hotspot. As part of the body’s initial response to infection or tissue damage, leukocytes are carried to infected or damaged tissues by blood vessels. To fight infection, they must exit the vessels, but how they exited was poorly understood. Young-Min Hyun at the Yonsei University College of Medicine in Seoul, South Korea and co-workers used advanced imaging techniques to visualize leukocyte delivery. They found that many leukocytes use a single hotspot to enter the blood vessel wall, travel through the wall’s interior, and then exit the wall at another hotspot. Using hotspots is thought to minimize the number of perforations in the vessel wall, maintaining vessel integrity. These results illuminate a key aspect of how efficiently the body fights infection from the viewpoint of leukocyte migration.https://doi.org/10.1038/s12276-019-0227-1 |
| spellingShingle | Young-Min Hyun Young Ho Choe Sang A. Park Minsoo Kim LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) distinctly regulate neutrophil extravasation through hotspots I and II Experimental and Molecular Medicine |
| title | LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) distinctly regulate neutrophil extravasation through hotspots I and II |
| title_full | LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) distinctly regulate neutrophil extravasation through hotspots I and II |
| title_fullStr | LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) distinctly regulate neutrophil extravasation through hotspots I and II |
| title_full_unstemmed | LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) distinctly regulate neutrophil extravasation through hotspots I and II |
| title_short | LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) distinctly regulate neutrophil extravasation through hotspots I and II |
| title_sort | lfa 1 cd11a cd18 and mac 1 cd11b cd18 distinctly regulate neutrophil extravasation through hotspots i and ii |
| url | https://doi.org/10.1038/s12276-019-0227-1 |
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