Cerebral Neural Changes in Venous–Arterial Extracorporeal Membrane Oxygenation Survivors
Background: Extracorporeal membrane oxygenation (ECMO) is used as temporary cardiorespiratory support in patients with critical ailments, but very little is known about the functional cerebral changes in ECMO survivors. Degree centrality (DC), a graph-based assessment of network organization, was pe...
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MDPI AG
2023-04-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/4/630 |
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| author | Jueyue Yan Zhipeng Xu Xing Fang Jingyu You Jianhua Niu Mi Xu Jingchen Zhang Jia Hu Xujian He Tong Li |
| author_facet | Jueyue Yan Zhipeng Xu Xing Fang Jingyu You Jianhua Niu Mi Xu Jingchen Zhang Jia Hu Xujian He Tong Li |
| author_sort | Jueyue Yan |
| collection | DOAJ |
| description | Background: Extracorporeal membrane oxygenation (ECMO) is used as temporary cardiorespiratory support in patients with critical ailments, but very little is known about the functional cerebral changes in ECMO survivors. Degree centrality (DC), a graph-based assessment of network organization, was performed to explore the neural connectivity changes in ECMO survivors compared to controls and their correlation with cognitive and neurological measures. Methods: This exploratory observational study was conducted from August 2020 to May 2022. ECMO survivors and controls underwent functional magnetic resonance imaging (fMRI) of the brain. We performed DC analysis to identify voxels that showed changes in whole-brain functional connectivity with other voxels. DC was measured by the fMRI graph method and comparisons between the two groups were performed. All participants underwent neuropsychological assessment (Montreal Cognitive Assessment, MoCA). Blood serum neuron-specific enolase and the Glasgow Coma Scale (GCS) were assessed in ECMO survivors. Results: DC values in the right insula and right precuneus gyrus were lower in ECMO survivors and higher in the right medial superior frontal gyrus compared to controls (all <i>p</i> < 0.001). Decreased connectivity in the right insular and right precuneus gyrus correlated with total MoCA scores, delayed recollection, and calculation (all <i>p</i> < 0.05). Increased serum NSE levels, GCS score, and GCS–motor response correlated with decreased connectivity in the right insular and right precuneus gyrus and increased connectivity in the right medial superior frontal gyrus (all <i>p</i> < 0.05). Conclusions: We showed that both functional impairment and adaptation were observed in survivors of ECMO, suggesting that neural connectivity changes may provide insights into the mechanisms that may potentially link ECMO survivors to neurological and cognitive disorders. |
| first_indexed | 2024-03-11T05:10:48Z |
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| id | doaj.art-26ae5d8cfb5b4c4ca10e9573df90cd5b |
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| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T05:10:48Z |
| publishDate | 2023-04-01 |
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| series | Brain Sciences |
| spelling | doaj.art-26ae5d8cfb5b4c4ca10e9573df90cd5b2023-11-17T18:32:53ZengMDPI AGBrain Sciences2076-34252023-04-0113463010.3390/brainsci13040630Cerebral Neural Changes in Venous–Arterial Extracorporeal Membrane Oxygenation SurvivorsJueyue Yan0Zhipeng Xu1Xing Fang2Jingyu You3Jianhua Niu4Mi Xu5Jingchen Zhang6Jia Hu7Xujian He8Tong Li9Department of Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, ChinaBackground: Extracorporeal membrane oxygenation (ECMO) is used as temporary cardiorespiratory support in patients with critical ailments, but very little is known about the functional cerebral changes in ECMO survivors. Degree centrality (DC), a graph-based assessment of network organization, was performed to explore the neural connectivity changes in ECMO survivors compared to controls and their correlation with cognitive and neurological measures. Methods: This exploratory observational study was conducted from August 2020 to May 2022. ECMO survivors and controls underwent functional magnetic resonance imaging (fMRI) of the brain. We performed DC analysis to identify voxels that showed changes in whole-brain functional connectivity with other voxels. DC was measured by the fMRI graph method and comparisons between the two groups were performed. All participants underwent neuropsychological assessment (Montreal Cognitive Assessment, MoCA). Blood serum neuron-specific enolase and the Glasgow Coma Scale (GCS) were assessed in ECMO survivors. Results: DC values in the right insula and right precuneus gyrus were lower in ECMO survivors and higher in the right medial superior frontal gyrus compared to controls (all <i>p</i> < 0.001). Decreased connectivity in the right insular and right precuneus gyrus correlated with total MoCA scores, delayed recollection, and calculation (all <i>p</i> < 0.05). Increased serum NSE levels, GCS score, and GCS–motor response correlated with decreased connectivity in the right insular and right precuneus gyrus and increased connectivity in the right medial superior frontal gyrus (all <i>p</i> < 0.05). Conclusions: We showed that both functional impairment and adaptation were observed in survivors of ECMO, suggesting that neural connectivity changes may provide insights into the mechanisms that may potentially link ECMO survivors to neurological and cognitive disorders.https://www.mdpi.com/2076-3425/13/4/630extracorporeal membrane oxygenationcognitionmagnetic resonance imagingdegree centrality |
| spellingShingle | Jueyue Yan Zhipeng Xu Xing Fang Jingyu You Jianhua Niu Mi Xu Jingchen Zhang Jia Hu Xujian He Tong Li Cerebral Neural Changes in Venous–Arterial Extracorporeal Membrane Oxygenation Survivors Brain Sciences extracorporeal membrane oxygenation cognition magnetic resonance imaging degree centrality |
| title | Cerebral Neural Changes in Venous–Arterial Extracorporeal Membrane Oxygenation Survivors |
| title_full | Cerebral Neural Changes in Venous–Arterial Extracorporeal Membrane Oxygenation Survivors |
| title_fullStr | Cerebral Neural Changes in Venous–Arterial Extracorporeal Membrane Oxygenation Survivors |
| title_full_unstemmed | Cerebral Neural Changes in Venous–Arterial Extracorporeal Membrane Oxygenation Survivors |
| title_short | Cerebral Neural Changes in Venous–Arterial Extracorporeal Membrane Oxygenation Survivors |
| title_sort | cerebral neural changes in venous arterial extracorporeal membrane oxygenation survivors |
| topic | extracorporeal membrane oxygenation cognition magnetic resonance imaging degree centrality |
| url | https://www.mdpi.com/2076-3425/13/4/630 |
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