The Impact of Hyperkalemia on Mortality and Healthcare Resource Utilization Among Patients With Chronic Kidney Disease: A Matched Cohort Study in China
ObjectivesThis study aimed to estimate the impact of hyperkalemia on 1-year survival and all-cause healthcare resource utilization among patients with chronic kidney disease in China.MethodsAdult new-onset chronic kidney disease patients were identified between 2012 and 2016, among which the hyperka...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.855395/full |
| _version_ | 1818775270339903488 |
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| author | Jiahui Zhang Jiahui Zhang Xiaoning He Xiaoning He Jing Wu Jing Wu |
| author_facet | Jiahui Zhang Jiahui Zhang Xiaoning He Xiaoning He Jing Wu Jing Wu |
| author_sort | Jiahui Zhang |
| collection | DOAJ |
| description | ObjectivesThis study aimed to estimate the impact of hyperkalemia on 1-year survival and all-cause healthcare resource utilization among patients with chronic kidney disease in China.MethodsAdult new-onset chronic kidney disease patients were identified between 2012 and 2016, among which the hyperkalemia and non-hyperkalemia cohorts were further selected and matched. Survival and all-cause healthcare resource utilization during a 12 month period were compared using Kaplan-Meier curves with log-rank test, Cox proportional hazard model, and Kaplan-Meier sample average method.ResultsAmong 1,003 pairs of patients (mean age 67.2 ± 14.3 years), the 1-year all-cause mortality was 5.39-times higher in the hyperkalemia cohort than the non-hyperkalemia cohort (hazard ratio = 5.39, P < 0.001). The mean costs and number of healthcare services among the hyperkalemia patients were significantly higher (P < 0.05) in each follow-up month. An annual increase cost of ¥38,479 was observed in the hyperkalemia cohort, largely due to the sharp increase in inpatient costs during the first month after hyperkalemia events (¥22,204 vs. 1,032, P < 0.001). Medication costs were the most important cost component for both cohorts [¥26,786 (45%) vs. ¥12,378(60%)]. However, hyperkalemia patients spent more on non-medication treatment [¥13,410(23%) vs. ¥2,335(11%)] including nursing, monitoring, etc. Hyperkalemia patients had more annual inpatient admissions (1.9 vs. 0.7) and length of stays (28.6 vs. 8.7), while the number of outpatient visits (36.8 vs. 36.4) were similar.ConclusionsIn Chinese chronic kidney disease patients, hyperkalemia is associated with substantially increased clinical and economic burdens that are driven by the short period following the hyperkalemia events, which strengthens calls for sufficient supervision and management of serum potassium. |
| first_indexed | 2024-12-18T10:54:22Z |
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| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-12-18T10:54:22Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-26af3628f9234b3891d9bbe9b8f60fb92022-12-21T21:10:23ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-03-011010.3389/fpubh.2022.855395855395The Impact of Hyperkalemia on Mortality and Healthcare Resource Utilization Among Patients With Chronic Kidney Disease: A Matched Cohort Study in ChinaJiahui Zhang0Jiahui Zhang1Xiaoning He2Xiaoning He3Jing Wu4Jing Wu5School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, ChinaCenter for Social Science Survey and Data, Tianjin University, Tianjin, ChinaSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin, ChinaCenter for Social Science Survey and Data, Tianjin University, Tianjin, ChinaSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin, ChinaCenter for Social Science Survey and Data, Tianjin University, Tianjin, ChinaObjectivesThis study aimed to estimate the impact of hyperkalemia on 1-year survival and all-cause healthcare resource utilization among patients with chronic kidney disease in China.MethodsAdult new-onset chronic kidney disease patients were identified between 2012 and 2016, among which the hyperkalemia and non-hyperkalemia cohorts were further selected and matched. Survival and all-cause healthcare resource utilization during a 12 month period were compared using Kaplan-Meier curves with log-rank test, Cox proportional hazard model, and Kaplan-Meier sample average method.ResultsAmong 1,003 pairs of patients (mean age 67.2 ± 14.3 years), the 1-year all-cause mortality was 5.39-times higher in the hyperkalemia cohort than the non-hyperkalemia cohort (hazard ratio = 5.39, P < 0.001). The mean costs and number of healthcare services among the hyperkalemia patients were significantly higher (P < 0.05) in each follow-up month. An annual increase cost of ¥38,479 was observed in the hyperkalemia cohort, largely due to the sharp increase in inpatient costs during the first month after hyperkalemia events (¥22,204 vs. 1,032, P < 0.001). Medication costs were the most important cost component for both cohorts [¥26,786 (45%) vs. ¥12,378(60%)]. However, hyperkalemia patients spent more on non-medication treatment [¥13,410(23%) vs. ¥2,335(11%)] including nursing, monitoring, etc. Hyperkalemia patients had more annual inpatient admissions (1.9 vs. 0.7) and length of stays (28.6 vs. 8.7), while the number of outpatient visits (36.8 vs. 36.4) were similar.ConclusionsIn Chinese chronic kidney disease patients, hyperkalemia is associated with substantially increased clinical and economic burdens that are driven by the short period following the hyperkalemia events, which strengthens calls for sufficient supervision and management of serum potassium.https://www.frontiersin.org/articles/10.3389/fpubh.2022.855395/fullchronic kidney diseasehyperkalemiamortalityhealthcare resource utilizationcosts |
| spellingShingle | Jiahui Zhang Jiahui Zhang Xiaoning He Xiaoning He Jing Wu Jing Wu The Impact of Hyperkalemia on Mortality and Healthcare Resource Utilization Among Patients With Chronic Kidney Disease: A Matched Cohort Study in China Frontiers in Public Health chronic kidney disease hyperkalemia mortality healthcare resource utilization costs |
| title | The Impact of Hyperkalemia on Mortality and Healthcare Resource Utilization Among Patients With Chronic Kidney Disease: A Matched Cohort Study in China |
| title_full | The Impact of Hyperkalemia on Mortality and Healthcare Resource Utilization Among Patients With Chronic Kidney Disease: A Matched Cohort Study in China |
| title_fullStr | The Impact of Hyperkalemia on Mortality and Healthcare Resource Utilization Among Patients With Chronic Kidney Disease: A Matched Cohort Study in China |
| title_full_unstemmed | The Impact of Hyperkalemia on Mortality and Healthcare Resource Utilization Among Patients With Chronic Kidney Disease: A Matched Cohort Study in China |
| title_short | The Impact of Hyperkalemia on Mortality and Healthcare Resource Utilization Among Patients With Chronic Kidney Disease: A Matched Cohort Study in China |
| title_sort | impact of hyperkalemia on mortality and healthcare resource utilization among patients with chronic kidney disease a matched cohort study in china |
| topic | chronic kidney disease hyperkalemia mortality healthcare resource utilization costs |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.855395/full |
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