Postoperative Bladder Neck to Pubic Symphysis Ratio Predictive for De Novo Overactive Bladder after Robot-Assisted Radical Prostatectomy
Background: The aim was to investigate the incidence and clinical predictive factors of de novo overactive bladder (OAB) after robot-assisted radical prostatectomy (RARP), including a Retzius-sparing (RS) approach, in the same period at a single institution. Methods: Of a total of 113 patients with...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/13/20/3173 |
| _version_ | 1827721211672526848 |
|---|---|
| author | Nayuka Matsuyama Taku Naiki Shuzo Hamamoto Yosuke Sugiyama Yasue Kubota Takashi Hamakawa Toshiki Etani Shoichiro Iwatsuki Kazumi Taguchi Yuya Ota Masakazu Gonda Maria Aoki Toshiharu Morikawa Taiki Kato Atsushi Okada Takahiro Yasui |
| author_facet | Nayuka Matsuyama Taku Naiki Shuzo Hamamoto Yosuke Sugiyama Yasue Kubota Takashi Hamakawa Toshiki Etani Shoichiro Iwatsuki Kazumi Taguchi Yuya Ota Masakazu Gonda Maria Aoki Toshiharu Morikawa Taiki Kato Atsushi Okada Takahiro Yasui |
| author_sort | Nayuka Matsuyama |
| collection | DOAJ |
| description | Background: The aim was to investigate the incidence and clinical predictive factors of de novo overactive bladder (OAB) after robot-assisted radical prostatectomy (RARP), including a Retzius-sparing (RS) approach, in the same period at a single institution. Methods: Of a total of 113 patients with localized prostate cancer, 81 received conventional RARP (CON-RARP) and 32 received RS-RARP at our institution. The basic characteristics data of patients and self-assessment questionnaires, including IPSS and OABSS, were obtained preoperatively and 1, 3, and 6 months after RARP. In addition, a retrospective biomarker analysis was also performed of predictive clinical parameters obtained from cystography that included a postoperative bladder neck to pubic symphysis (BNPS) ratio. Results: Patients’ basic characteristics were similar between CON-RARP and RS-RARP groups. With respect to the surgical procedure, anastomosing time was found to be significantly longer for patients in the RS-RARP compared to the CON-RARP group (<i>p</i> < 0.01). Compared to the CON-RARP group, the RS-RARP group showed a significantly lower postoperative BNPS and aspect ratio (<i>p</i> < 0.001). The incidence of de novo OAB in patients of the CON-RARP group was greater than for those in the RS-RARP group (40.7% CON-RARP vs. 25.0% RS-RARP), though this was not significant. Regarding the emergence of de novo OAB, the following were revealed in univariate analysis to be independent prognostic factors: age > 64 years (hazards ratio [HR]: 4.32, 95% confidence interval [CI]: 1.51–12.3), postoperative BNPS ratio > 0.44 (HR: 8.7, 95% CI: 6.43–54.5), postoperative aspect ratio > 1.18 (HR: 3.36, 95% CI: 1.49–7.61). Additionally, multivariate analysis identified a sole significant prognostic factor: postoperative BNPS ratio > 0.44 (HR: 13.3, 95% CI: 4.33–41.1). Conclusion: Our findings indicate that the postoperative BNPS ratio may be a practical predictive indicator of the emergence of de novo OAB after RARP. |
| first_indexed | 2024-03-10T21:19:20Z |
| format | Article |
| id | doaj.art-26af7ff8e6da4c7eb8bb416591e59340 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T21:19:20Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-26af7ff8e6da4c7eb8bb416591e593402023-11-19T16:12:18ZengMDPI AGDiagnostics2075-44182023-10-011320317310.3390/diagnostics13203173Postoperative Bladder Neck to Pubic Symphysis Ratio Predictive for De Novo Overactive Bladder after Robot-Assisted Radical ProstatectomyNayuka Matsuyama0Taku Naiki1Shuzo Hamamoto2Yosuke Sugiyama3Yasue Kubota4Takashi Hamakawa5Toshiki Etani6Shoichiro Iwatsuki7Kazumi Taguchi8Yuya Ota9Masakazu Gonda10Maria Aoki11Toshiharu Morikawa12Taiki Kato13Atsushi Okada14Takahiro Yasui15Department of Nephro-Urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, JapanDepartment of Nephro-Urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, JapanDepartment of Nephro-Urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, JapanDepartment of Pharmacy, Nagoya City University Hospital, Nagoya 467-8601, JapanDepartment of Clinical Physiology, Graduate School of Nursing, Nagoya City University, Nagoya 467-8601, JapanDepartment of Urology, Nagoya City University West Medical Center, Nagoya 462-8508, JapanDepartment of Nephro-Urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, JapanDepartment of Nephro-Urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, JapanDepartment of Nephro-Urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, JapanDepartment of Nephro-Urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, JapanDepartment of Nephro-Urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, JapanDepartment of Nephro-Urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, JapanDepartment of Nephro-Urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, JapanDepartment of Urology, Nagoya City University East Medical Center, Nagoya 464-8547, JapanDepartment of Nephro-Urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, JapanDepartment of Nephro-Urology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, JapanBackground: The aim was to investigate the incidence and clinical predictive factors of de novo overactive bladder (OAB) after robot-assisted radical prostatectomy (RARP), including a Retzius-sparing (RS) approach, in the same period at a single institution. Methods: Of a total of 113 patients with localized prostate cancer, 81 received conventional RARP (CON-RARP) and 32 received RS-RARP at our institution. The basic characteristics data of patients and self-assessment questionnaires, including IPSS and OABSS, were obtained preoperatively and 1, 3, and 6 months after RARP. In addition, a retrospective biomarker analysis was also performed of predictive clinical parameters obtained from cystography that included a postoperative bladder neck to pubic symphysis (BNPS) ratio. Results: Patients’ basic characteristics were similar between CON-RARP and RS-RARP groups. With respect to the surgical procedure, anastomosing time was found to be significantly longer for patients in the RS-RARP compared to the CON-RARP group (<i>p</i> < 0.01). Compared to the CON-RARP group, the RS-RARP group showed a significantly lower postoperative BNPS and aspect ratio (<i>p</i> < 0.001). The incidence of de novo OAB in patients of the CON-RARP group was greater than for those in the RS-RARP group (40.7% CON-RARP vs. 25.0% RS-RARP), though this was not significant. Regarding the emergence of de novo OAB, the following were revealed in univariate analysis to be independent prognostic factors: age > 64 years (hazards ratio [HR]: 4.32, 95% confidence interval [CI]: 1.51–12.3), postoperative BNPS ratio > 0.44 (HR: 8.7, 95% CI: 6.43–54.5), postoperative aspect ratio > 1.18 (HR: 3.36, 95% CI: 1.49–7.61). Additionally, multivariate analysis identified a sole significant prognostic factor: postoperative BNPS ratio > 0.44 (HR: 13.3, 95% CI: 4.33–41.1). Conclusion: Our findings indicate that the postoperative BNPS ratio may be a practical predictive indicator of the emergence of de novo OAB after RARP.https://www.mdpi.com/2075-4418/13/20/3173de novo overactive bladderpostoperative bladder neck to pubic symphysis ratioRetzius sparing |
| spellingShingle | Nayuka Matsuyama Taku Naiki Shuzo Hamamoto Yosuke Sugiyama Yasue Kubota Takashi Hamakawa Toshiki Etani Shoichiro Iwatsuki Kazumi Taguchi Yuya Ota Masakazu Gonda Maria Aoki Toshiharu Morikawa Taiki Kato Atsushi Okada Takahiro Yasui Postoperative Bladder Neck to Pubic Symphysis Ratio Predictive for De Novo Overactive Bladder after Robot-Assisted Radical Prostatectomy Diagnostics de novo overactive bladder postoperative bladder neck to pubic symphysis ratio Retzius sparing |
| title | Postoperative Bladder Neck to Pubic Symphysis Ratio Predictive for De Novo Overactive Bladder after Robot-Assisted Radical Prostatectomy |
| title_full | Postoperative Bladder Neck to Pubic Symphysis Ratio Predictive for De Novo Overactive Bladder after Robot-Assisted Radical Prostatectomy |
| title_fullStr | Postoperative Bladder Neck to Pubic Symphysis Ratio Predictive for De Novo Overactive Bladder after Robot-Assisted Radical Prostatectomy |
| title_full_unstemmed | Postoperative Bladder Neck to Pubic Symphysis Ratio Predictive for De Novo Overactive Bladder after Robot-Assisted Radical Prostatectomy |
| title_short | Postoperative Bladder Neck to Pubic Symphysis Ratio Predictive for De Novo Overactive Bladder after Robot-Assisted Radical Prostatectomy |
| title_sort | postoperative bladder neck to pubic symphysis ratio predictive for de novo overactive bladder after robot assisted radical prostatectomy |
| topic | de novo overactive bladder postoperative bladder neck to pubic symphysis ratio Retzius sparing |
| url | https://www.mdpi.com/2075-4418/13/20/3173 |
| work_keys_str_mv | AT nayukamatsuyama postoperativebladdernecktopubicsymphysisratiopredictivefordenovooveractivebladderafterrobotassistedradicalprostatectomy AT takunaiki postoperativebladdernecktopubicsymphysisratiopredictivefordenovooveractivebladderafterrobotassistedradicalprostatectomy AT shuzohamamoto postoperativebladdernecktopubicsymphysisratiopredictivefordenovooveractivebladderafterrobotassistedradicalprostatectomy AT yosukesugiyama postoperativebladdernecktopubicsymphysisratiopredictivefordenovooveractivebladderafterrobotassistedradicalprostatectomy AT yasuekubota postoperativebladdernecktopubicsymphysisratiopredictivefordenovooveractivebladderafterrobotassistedradicalprostatectomy AT takashihamakawa postoperativebladdernecktopubicsymphysisratiopredictivefordenovooveractivebladderafterrobotassistedradicalprostatectomy AT toshikietani postoperativebladdernecktopubicsymphysisratiopredictivefordenovooveractivebladderafterrobotassistedradicalprostatectomy AT shoichiroiwatsuki postoperativebladdernecktopubicsymphysisratiopredictivefordenovooveractivebladderafterrobotassistedradicalprostatectomy AT kazumitaguchi postoperativebladdernecktopubicsymphysisratiopredictivefordenovooveractivebladderafterrobotassistedradicalprostatectomy AT yuyaota postoperativebladdernecktopubicsymphysisratiopredictivefordenovooveractivebladderafterrobotassistedradicalprostatectomy AT masakazugonda postoperativebladdernecktopubicsymphysisratiopredictivefordenovooveractivebladderafterrobotassistedradicalprostatectomy AT mariaaoki postoperativebladdernecktopubicsymphysisratiopredictivefordenovooveractivebladderafterrobotassistedradicalprostatectomy AT toshiharumorikawa postoperativebladdernecktopubicsymphysisratiopredictivefordenovooveractivebladderafterrobotassistedradicalprostatectomy AT taikikato postoperativebladdernecktopubicsymphysisratiopredictivefordenovooveractivebladderafterrobotassistedradicalprostatectomy AT atsushiokada postoperativebladdernecktopubicsymphysisratiopredictivefordenovooveractivebladderafterrobotassistedradicalprostatectomy AT takahiroyasui postoperativebladdernecktopubicsymphysisratiopredictivefordenovooveractivebladderafterrobotassistedradicalprostatectomy |