2-[2-(Aziridin-1-yl)ethyl]-5,5-dimethyl-2,5-dihydro-4H-benzo [e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part IV)
An aziridine-containing side chain is attached to an oxonaphthalene-annelated pyrrole in expectation of DNA alkylating properties. The cytotoxicity is evaluated against two cell lines, KB-31 and KB-8511, respectively.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-10-01
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| Series: | Molbank |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1422-8599/2012/4/M781 |
| _version_ | 1828171489143160832 |
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| author | Helmut Spreitzer Christiane Puschmann |
| author_facet | Helmut Spreitzer Christiane Puschmann |
| author_sort | Helmut Spreitzer |
| collection | DOAJ |
| description | An aziridine-containing side chain is attached to an oxonaphthalene-annelated pyrrole in expectation of DNA alkylating properties. The cytotoxicity is evaluated against two cell lines, KB-31 and KB-8511, respectively. |
| first_indexed | 2024-04-12T03:26:54Z |
| format | Article |
| id | doaj.art-26b19bb7f6d541fe88d3f9b7aa7d7622 |
| institution | Directory Open Access Journal |
| issn | 1422-8599 |
| language | English |
| last_indexed | 2024-04-12T03:26:54Z |
| publishDate | 2012-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj.art-26b19bb7f6d541fe88d3f9b7aa7d76222022-12-22T03:49:38ZengMDPI AGMolbank1422-85992012-10-0120124M78110.3390/M7812-[2-(Aziridin-1-yl)ethyl]-5,5-dimethyl-2,5-dihydro-4H-benzo [e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part IV)Helmut SpreitzerChristiane PuschmannAn aziridine-containing side chain is attached to an oxonaphthalene-annelated pyrrole in expectation of DNA alkylating properties. The cytotoxicity is evaluated against two cell lines, KB-31 and KB-8511, respectively.http://www.mdpi.com/1422-8599/2012/4/M781pyrroleDNA-alkylationanticancer |
| spellingShingle | Helmut Spreitzer Christiane Puschmann 2-[2-(Aziridin-1-yl)ethyl]-5,5-dimethyl-2,5-dihydro-4H-benzo [e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part IV) Molbank pyrrole DNA-alkylation anticancer |
| title | 2-[2-(Aziridin-1-yl)ethyl]-5,5-dimethyl-2,5-dihydro-4H-benzo [e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part IV) |
| title_full | 2-[2-(Aziridin-1-yl)ethyl]-5,5-dimethyl-2,5-dihydro-4H-benzo [e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part IV) |
| title_fullStr | 2-[2-(Aziridin-1-yl)ethyl]-5,5-dimethyl-2,5-dihydro-4H-benzo [e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part IV) |
| title_full_unstemmed | 2-[2-(Aziridin-1-yl)ethyl]-5,5-dimethyl-2,5-dihydro-4H-benzo [e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part IV) |
| title_short | 2-[2-(Aziridin-1-yl)ethyl]-5,5-dimethyl-2,5-dihydro-4H-benzo [e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part IV) |
| title_sort | 2 2 aziridin 1 yl ethyl 5 5 dimethyl 2 5 dihydro 4h benzo e isoindol 4 one cytotoxic oxonaphthalene pyrroles part iv |
| topic | pyrrole DNA-alkylation anticancer |
| url | http://www.mdpi.com/1422-8599/2012/4/M781 |
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