Nanohydroxyapatite/Peptide Composite Coatings on Pure Titanium Surfaces with Nanonetwork Structures Using Oyster Shells
Titanium and its alloys are extensively applied in artificial tooth roots because of their excellent corrosion resistance, high specific strength, and low elastic modulus. However, because of their biological inertness, their surface needs to be modified to improve the osteointegration of titanium i...
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| Format: | Article |
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MDPI AG
2024-03-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/14/7/577 |
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| author | Kuan-Hsiang Hsieh Hsueh-Chuan Hsu Yu-Lin Kao Shih-Ching Wu Tzu-Yen Yang Wen-Fu Ho |
| author_facet | Kuan-Hsiang Hsieh Hsueh-Chuan Hsu Yu-Lin Kao Shih-Ching Wu Tzu-Yen Yang Wen-Fu Ho |
| author_sort | Kuan-Hsiang Hsieh |
| collection | DOAJ |
| description | Titanium and its alloys are extensively applied in artificial tooth roots because of their excellent corrosion resistance, high specific strength, and low elastic modulus. However, because of their biological inertness, their surface needs to be modified to improve the osteointegration of titanium implants. The preparation of biologically active calcium–phosphorus coatings on the surface of an implant is one effective method for enhancing the likelihood of bone integration. In this study, osteoinductive peptides were extracted from oyster shells by using acetic acid. Two peptide-containing hydroxyapatite (HA) composite coatings were then prepared: one coating was prepared by hydrothermally synthesizing an HA coating in the presence of peptides (HA/P/M), and the other coating was prepared by hydrothermally synthesizing HA and then immersing the hydrothermally synthesized HA in a peptide solution (HA/P/S). Characterization results indicated that the composite HA coatings containing oyster shell-based peptides were successfully prepared on the alkali-treated pure titanium surfaces. The HA/P/M and HA/P/S composite coatings were found to exhibit excellent hydrophilicity. Protein adsorption tests confirmed that the HA/P/M and HA/P/S coatings had an approximately 2.3 times higher concentration of adsorbed proteins than the pure HA coating. |
| first_indexed | 2024-04-24T10:37:40Z |
| format | Article |
| id | doaj.art-26b4884972c24a889fb62b478b6e982a |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-04-24T10:37:40Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-26b4884972c24a889fb62b478b6e982a2024-04-12T13:23:50ZengMDPI AGNanomaterials2079-49912024-03-0114757710.3390/nano14070577Nanohydroxyapatite/Peptide Composite Coatings on Pure Titanium Surfaces with Nanonetwork Structures Using Oyster ShellsKuan-Hsiang Hsieh0Hsueh-Chuan Hsu1Yu-Lin Kao2Shih-Ching Wu3Tzu-Yen Yang4Wen-Fu Ho5Department of Surgery, Division of Orthopaedics, Zuoying Armed Forces General Hospital, Kaohsiung 813204, TaiwanDepartment of Dental Technology and Materials Science, Central Taiwan University of Science and Technology, Taichung 406053, TaiwanDepartment of Life Sciences, National University of Kaohsiung, Kaohsiung 811726, TaiwanDepartment of Dental Technology and Materials Science, Central Taiwan University of Science and Technology, Taichung 406053, TaiwanDepartment of Chemical and Materials Engineering, National University of Kaohsiung, Kaohsiung 811726, TaiwanDepartment of Chemical and Materials Engineering, National University of Kaohsiung, Kaohsiung 811726, TaiwanTitanium and its alloys are extensively applied in artificial tooth roots because of their excellent corrosion resistance, high specific strength, and low elastic modulus. However, because of their biological inertness, their surface needs to be modified to improve the osteointegration of titanium implants. The preparation of biologically active calcium–phosphorus coatings on the surface of an implant is one effective method for enhancing the likelihood of bone integration. In this study, osteoinductive peptides were extracted from oyster shells by using acetic acid. Two peptide-containing hydroxyapatite (HA) composite coatings were then prepared: one coating was prepared by hydrothermally synthesizing an HA coating in the presence of peptides (HA/P/M), and the other coating was prepared by hydrothermally synthesizing HA and then immersing the hydrothermally synthesized HA in a peptide solution (HA/P/S). Characterization results indicated that the composite HA coatings containing oyster shell-based peptides were successfully prepared on the alkali-treated pure titanium surfaces. The HA/P/M and HA/P/S composite coatings were found to exhibit excellent hydrophilicity. Protein adsorption tests confirmed that the HA/P/M and HA/P/S coatings had an approximately 2.3 times higher concentration of adsorbed proteins than the pure HA coating.https://www.mdpi.com/2079-4991/14/7/577titaniumhydrothermal synthesisoyster shellshydroxyapatitepeptides |
| spellingShingle | Kuan-Hsiang Hsieh Hsueh-Chuan Hsu Yu-Lin Kao Shih-Ching Wu Tzu-Yen Yang Wen-Fu Ho Nanohydroxyapatite/Peptide Composite Coatings on Pure Titanium Surfaces with Nanonetwork Structures Using Oyster Shells Nanomaterials titanium hydrothermal synthesis oyster shells hydroxyapatite peptides |
| title | Nanohydroxyapatite/Peptide Composite Coatings on Pure Titanium Surfaces with Nanonetwork Structures Using Oyster Shells |
| title_full | Nanohydroxyapatite/Peptide Composite Coatings on Pure Titanium Surfaces with Nanonetwork Structures Using Oyster Shells |
| title_fullStr | Nanohydroxyapatite/Peptide Composite Coatings on Pure Titanium Surfaces with Nanonetwork Structures Using Oyster Shells |
| title_full_unstemmed | Nanohydroxyapatite/Peptide Composite Coatings on Pure Titanium Surfaces with Nanonetwork Structures Using Oyster Shells |
| title_short | Nanohydroxyapatite/Peptide Composite Coatings on Pure Titanium Surfaces with Nanonetwork Structures Using Oyster Shells |
| title_sort | nanohydroxyapatite peptide composite coatings on pure titanium surfaces with nanonetwork structures using oyster shells |
| topic | titanium hydrothermal synthesis oyster shells hydroxyapatite peptides |
| url | https://www.mdpi.com/2079-4991/14/7/577 |
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