Paracrine IFN Response Limits ZIKV Infection in Human Sertoli Cells

Paracrine IFN Response Limits ZIKV Infection in Human Sertoli Cells

Zika virus (ZIKV) is unique among mosquito-borne flaviviruses in its ability to be sexually transmitted. The testes have been implicated as sites of long-term ZIKV replication, and our previous studies have identified Sertoli cells (SC), the nurse cells of the seminiferous epithelium that govern spe...

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Bibliographic Details
Main Authors: Daniel P. Strange, Boonyanudh Jiyarom, Hooman Sadri-Ardekani, Lisa H. Cazares, Tara A. Kenny, Michael D. Ward, Saguna Verma
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Microbiology
Subjects:
ZIKV
testes
Sertoli cells
IFN response
host-ZIKV interaction
ISGs
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.667146/full

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