The Role of Glial Cells in Different Phases of Migraine: Lessons from Preclinical Studies
Migraine is a complex and debilitating neurological disease that affects 15% of the population worldwide. It is defined by the presence of recurrent severe attacks of disabling headache accompanied by other debilitating neurological symptoms. Important advancements have linked the trigeminovascular...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/16/12553 |
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| author | Marta Vila-Pueyo Otilia Gliga Víctor José Gallardo Patricia Pozo-Rosich |
| author_facet | Marta Vila-Pueyo Otilia Gliga Víctor José Gallardo Patricia Pozo-Rosich |
| author_sort | Marta Vila-Pueyo |
| collection | DOAJ |
| description | Migraine is a complex and debilitating neurological disease that affects 15% of the population worldwide. It is defined by the presence of recurrent severe attacks of disabling headache accompanied by other debilitating neurological symptoms. Important advancements have linked the trigeminovascular system and the neuropeptide calcitonin gene-related peptide to migraine pathophysiology, but the mechanisms underlying its pathogenesis and chronification remain unknown. Glial cells are essential for the correct development and functioning of the nervous system and, due to its implication in neurological diseases, have been hypothesised to have a role in migraine. Here we provide a narrative review of the role of glia in different phases of migraine through the analysis of preclinical studies. Current evidence shows that astrocytes and microglia are involved in the initiation and propagation of cortical spreading depolarization, the neurophysiological correlate of migraine aura. Furthermore, satellite glial cells within the trigeminal ganglia are implicated in the initiation and maintenance of orofacial pain, suggesting a role in the headache phase of migraine. Moreover, microglia in the trigeminocervical complex are involved in central sensitization, suggesting a role in chronic migraine. Taken altogether, glial cells have emerged as key players in migraine pathogenesis and chronification and future therapeutic strategies could be focused on targeting them to reduce the burden of migraine. |
| first_indexed | 2024-03-10T23:53:08Z |
| format | Article |
| id | doaj.art-26b65eb53d8c42d690829a435da08a74 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:53:08Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-26b65eb53d8c42d690829a435da08a742023-11-19T01:24:46ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124161255310.3390/ijms241612553The Role of Glial Cells in Different Phases of Migraine: Lessons from Preclinical StudiesMarta Vila-Pueyo0Otilia Gliga1Víctor José Gallardo2Patricia Pozo-Rosich3Headache and Neurological Pain Research Group, Vall d’Hebron Institute of Research (VHIR), Universitat Autònoma de Barcelona, 119-129 Passeig de la Vall d’Hebron, 08035 Barcelona, SpainHeadache and Neurological Pain Research Group, Vall d’Hebron Institute of Research (VHIR), Universitat Autònoma de Barcelona, 119-129 Passeig de la Vall d’Hebron, 08035 Barcelona, SpainHeadache and Neurological Pain Research Group, Vall d’Hebron Institute of Research (VHIR), Universitat Autònoma de Barcelona, 119-129 Passeig de la Vall d’Hebron, 08035 Barcelona, SpainHeadache and Neurological Pain Research Group, Vall d’Hebron Institute of Research (VHIR), Universitat Autònoma de Barcelona, 119-129 Passeig de la Vall d’Hebron, 08035 Barcelona, SpainMigraine is a complex and debilitating neurological disease that affects 15% of the population worldwide. It is defined by the presence of recurrent severe attacks of disabling headache accompanied by other debilitating neurological symptoms. Important advancements have linked the trigeminovascular system and the neuropeptide calcitonin gene-related peptide to migraine pathophysiology, but the mechanisms underlying its pathogenesis and chronification remain unknown. Glial cells are essential for the correct development and functioning of the nervous system and, due to its implication in neurological diseases, have been hypothesised to have a role in migraine. Here we provide a narrative review of the role of glia in different phases of migraine through the analysis of preclinical studies. Current evidence shows that astrocytes and microglia are involved in the initiation and propagation of cortical spreading depolarization, the neurophysiological correlate of migraine aura. Furthermore, satellite glial cells within the trigeminal ganglia are implicated in the initiation and maintenance of orofacial pain, suggesting a role in the headache phase of migraine. Moreover, microglia in the trigeminocervical complex are involved in central sensitization, suggesting a role in chronic migraine. Taken altogether, glial cells have emerged as key players in migraine pathogenesis and chronification and future therapeutic strategies could be focused on targeting them to reduce the burden of migraine.https://www.mdpi.com/1422-0067/24/16/12553migrainegliaastrocytemicrogliasatellite glial cellcortical spreading depolarization |
| spellingShingle | Marta Vila-Pueyo Otilia Gliga Víctor José Gallardo Patricia Pozo-Rosich The Role of Glial Cells in Different Phases of Migraine: Lessons from Preclinical Studies International Journal of Molecular Sciences migraine glia astrocyte microglia satellite glial cell cortical spreading depolarization |
| title | The Role of Glial Cells in Different Phases of Migraine: Lessons from Preclinical Studies |
| title_full | The Role of Glial Cells in Different Phases of Migraine: Lessons from Preclinical Studies |
| title_fullStr | The Role of Glial Cells in Different Phases of Migraine: Lessons from Preclinical Studies |
| title_full_unstemmed | The Role of Glial Cells in Different Phases of Migraine: Lessons from Preclinical Studies |
| title_short | The Role of Glial Cells in Different Phases of Migraine: Lessons from Preclinical Studies |
| title_sort | role of glial cells in different phases of migraine lessons from preclinical studies |
| topic | migraine glia astrocyte microglia satellite glial cell cortical spreading depolarization |
| url | https://www.mdpi.com/1422-0067/24/16/12553 |
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