Carbonic anhydrase versatility: from pH regulation to CO2 sensing and metabolism
While the carbonic anhydrase (CA, EC 4.2.1.1) superfamily of enzymes has been described primarily as involved only in pH regulation for decades, it also has many other important functions. CO2, bicarbonate, and protons, the physiological substrates of CA, are indeed the main buffering system in orga...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1326633/full |
| _version_ | 1827763565996539904 |
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| author | Claudiu T. Supuran |
| author_facet | Claudiu T. Supuran |
| author_sort | Claudiu T. Supuran |
| collection | DOAJ |
| description | While the carbonic anhydrase (CA, EC 4.2.1.1) superfamily of enzymes has been described primarily as involved only in pH regulation for decades, it also has many other important functions. CO2, bicarbonate, and protons, the physiological substrates of CA, are indeed the main buffering system in organisms belonging to all life kingdoms; however, in the last period, relevant progress has been made in the direction of elucidating the involvement of the eight genetically distinct CA families in chemical sensing, metabolism, and several other crucial physiological processes. Interference with CA activity, both by inhibiting and activating these enzymes, has thus led to novel applications for CA inhibitors and activators in the field of innovative biomedicine and environment and health. In this perspective article, I will discuss the recent advances which have allowed for a deeper understanding of the biochemistry of these versatile enzymes and various applications of their modulators of activity. |
| first_indexed | 2024-03-11T10:53:50Z |
| format | Article |
| id | doaj.art-26b700862adf4b9e8a9f439993c98ba1 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-03-11T10:53:50Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-26b700862adf4b9e8a9f439993c98ba12023-11-13T11:45:10ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2023-11-011010.3389/fmolb.2023.13266331326633Carbonic anhydrase versatility: from pH regulation to CO2 sensing and metabolismClaudiu T. SupuranWhile the carbonic anhydrase (CA, EC 4.2.1.1) superfamily of enzymes has been described primarily as involved only in pH regulation for decades, it also has many other important functions. CO2, bicarbonate, and protons, the physiological substrates of CA, are indeed the main buffering system in organisms belonging to all life kingdoms; however, in the last period, relevant progress has been made in the direction of elucidating the involvement of the eight genetically distinct CA families in chemical sensing, metabolism, and several other crucial physiological processes. Interference with CA activity, both by inhibiting and activating these enzymes, has thus led to novel applications for CA inhibitors and activators in the field of innovative biomedicine and environment and health. In this perspective article, I will discuss the recent advances which have allowed for a deeper understanding of the biochemistry of these versatile enzymes and various applications of their modulators of activity.https://www.frontiersin.org/articles/10.3389/fmolb.2023.1326633/fullcarbonic anhydrasepH regulationCO2/bicarbonate sensingmetabolisminhibitor |
| spellingShingle | Claudiu T. Supuran Carbonic anhydrase versatility: from pH regulation to CO2 sensing and metabolism Frontiers in Molecular Biosciences carbonic anhydrase pH regulation CO2/bicarbonate sensing metabolism inhibitor |
| title | Carbonic anhydrase versatility: from pH regulation to CO2 sensing and metabolism |
| title_full | Carbonic anhydrase versatility: from pH regulation to CO2 sensing and metabolism |
| title_fullStr | Carbonic anhydrase versatility: from pH regulation to CO2 sensing and metabolism |
| title_full_unstemmed | Carbonic anhydrase versatility: from pH regulation to CO2 sensing and metabolism |
| title_short | Carbonic anhydrase versatility: from pH regulation to CO2 sensing and metabolism |
| title_sort | carbonic anhydrase versatility from ph regulation to co2 sensing and metabolism |
| topic | carbonic anhydrase pH regulation CO2/bicarbonate sensing metabolism inhibitor |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1326633/full |
| work_keys_str_mv | AT claudiutsupuran carbonicanhydraseversatilityfromphregulationtoco2sensingandmetabolism |