Far-infrared suppresses skin photoaging in ultraviolet B-exposed fibroblasts and hairless mice.
Ultraviolet (UV) induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Collagen, which is one of the main building blocks of human skin, is regulated by collagen synthesis and collagen breakdown. Autophagy was found to block the epidermal hyperprolifera...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5354422?pdf=render |
| _version_ | 1818017294259847168 |
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| author | Hui-Wen Chiu Cheng-Hsien Chen Yi-Jie Chen Yung-Ho Hsu |
| author_facet | Hui-Wen Chiu Cheng-Hsien Chen Yi-Jie Chen Yung-Ho Hsu |
| author_sort | Hui-Wen Chiu |
| collection | DOAJ |
| description | Ultraviolet (UV) induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Collagen, which is one of the main building blocks of human skin, is regulated by collagen synthesis and collagen breakdown. Autophagy was found to block the epidermal hyperproliferative response to UVB and may play a crucial role in preventing skin photoaging. In the present study, we investigated whether far-infrared (FIR) therapy can inhibit skin photoaging via UVB irradiation in NIH 3T3 mouse embryonic fibroblasts and SKH-1 hairless mice. We found that FIR treatment significantly increased procollagen type I through the induction of the TGF-β/Smad axis. Furthermore, UVB significantly enhanced the expression of matrix metalloproteinase-1 (MMP-1) and MMP-9. FIR inhibited UVB-induced MMP-1 and MMP-9. Treatment with FIR reversed UVB-decreased type I collagen. In addition, FIR induced autophagy by inhibiting the Akt/mTOR signaling pathway. In UVB-induced skin photoaging in a hairless mouse model, FIR treatment resulted in decreased skin thickness in UVB irradiated mice and inhibited the degradation of collagen fibers. Moreover, FIR can increase procollagen type I via the inhibition of MMP-9 and induction of TGF-β in skin tissues. Therefore, our study provides evidence for the beneficial effects of FIR exposure in a model of skin photoaging. |
| first_indexed | 2024-04-14T07:24:17Z |
| format | Article |
| id | doaj.art-26b7cbbc1acd49849bfb914c733727cb |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T07:24:17Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-26b7cbbc1acd49849bfb914c733727cb2022-12-22T02:06:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01123e017404210.1371/journal.pone.0174042Far-infrared suppresses skin photoaging in ultraviolet B-exposed fibroblasts and hairless mice.Hui-Wen ChiuCheng-Hsien ChenYi-Jie ChenYung-Ho HsuUltraviolet (UV) induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Collagen, which is one of the main building blocks of human skin, is regulated by collagen synthesis and collagen breakdown. Autophagy was found to block the epidermal hyperproliferative response to UVB and may play a crucial role in preventing skin photoaging. In the present study, we investigated whether far-infrared (FIR) therapy can inhibit skin photoaging via UVB irradiation in NIH 3T3 mouse embryonic fibroblasts and SKH-1 hairless mice. We found that FIR treatment significantly increased procollagen type I through the induction of the TGF-β/Smad axis. Furthermore, UVB significantly enhanced the expression of matrix metalloproteinase-1 (MMP-1) and MMP-9. FIR inhibited UVB-induced MMP-1 and MMP-9. Treatment with FIR reversed UVB-decreased type I collagen. In addition, FIR induced autophagy by inhibiting the Akt/mTOR signaling pathway. In UVB-induced skin photoaging in a hairless mouse model, FIR treatment resulted in decreased skin thickness in UVB irradiated mice and inhibited the degradation of collagen fibers. Moreover, FIR can increase procollagen type I via the inhibition of MMP-9 and induction of TGF-β in skin tissues. Therefore, our study provides evidence for the beneficial effects of FIR exposure in a model of skin photoaging.http://europepmc.org/articles/PMC5354422?pdf=render |
| spellingShingle | Hui-Wen Chiu Cheng-Hsien Chen Yi-Jie Chen Yung-Ho Hsu Far-infrared suppresses skin photoaging in ultraviolet B-exposed fibroblasts and hairless mice. PLoS ONE |
| title | Far-infrared suppresses skin photoaging in ultraviolet B-exposed fibroblasts and hairless mice. |
| title_full | Far-infrared suppresses skin photoaging in ultraviolet B-exposed fibroblasts and hairless mice. |
| title_fullStr | Far-infrared suppresses skin photoaging in ultraviolet B-exposed fibroblasts and hairless mice. |
| title_full_unstemmed | Far-infrared suppresses skin photoaging in ultraviolet B-exposed fibroblasts and hairless mice. |
| title_short | Far-infrared suppresses skin photoaging in ultraviolet B-exposed fibroblasts and hairless mice. |
| title_sort | far infrared suppresses skin photoaging in ultraviolet b exposed fibroblasts and hairless mice |
| url | http://europepmc.org/articles/PMC5354422?pdf=render |
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