In bronchiectasis, poor physical capacity correlates with poor quality of life
Purpose Patients with bronchiectasis (BE) who suffer frequent exacerbations are likely to experience negative effects on quality of life (QoL) and require more healthcare utilization. We aimed to discover, in a cohort of Finnish BE patients, those risk factors that influence QoL.Methods Non-cystic f...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | European Clinical Respiratory Journal |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/20018525.2022.2095104 |
| _version_ | 1811229136175235072 |
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| author | Jarkko Mäntylä Witold Mazur Tanja Törölä Paula Bergman Paula Kauppi |
| author_facet | Jarkko Mäntylä Witold Mazur Tanja Törölä Paula Bergman Paula Kauppi |
| author_sort | Jarkko Mäntylä |
| collection | DOAJ |
| description | Purpose Patients with bronchiectasis (BE) who suffer frequent exacerbations are likely to experience negative effects on quality of life (QoL) and require more healthcare utilization. We aimed to discover, in a cohort of Finnish BE patients, those risk factors that influence QoL.Methods Non-cystic fibrosis BE patients of a Helsinki University Hospital cohort were examined with high-resolution computed tomography (HRCT) of the chest. They completed a disease-specific quality of life-bronchiectasis (QoL-B) questionnaire in Finnish translation. We considered scores in the lowest quarter (25%) of that QoL-B scale to indicate poor QoL. The bronchiectasis severity index (BSI), FACED score, and modified Medical Research Council (mMRC) dyspnoea scale were used.Results Overall, of 95 adult BE patients, mean age was 69 (SD ± 13) and 79% were women. From the cohort, 82% presented with chronic sputum production and exacerbations, at a median rate of 1.7 (SD ± 1.6). The number of exacerbations (OR 1.7), frequent exacerbations (≥3 per year) (OR 4.9), high BSI score (OR 1.3), and extensive disease (≥3 lobes) (OR 3.7) were all predictive of poor QoL. Frequent exacerbations were associated with bronchial bacterial colonisation, low forced expiratory volume in 1 s (FEV1), and radiological disease severity. Based on the BSI, 34.1% of our cohort had severe disease, with 11.6% classified as severe according to their FACED score. The mMRC dyspnoea score (r = −0.57) and BSI (r = −0.60) correlated, in the QoL-B questionnaire, negatively with physical domain.Conclusion The strongest determinants of poor QoL in the cohort of Finnish BE patients were frequent exacerbations, radiological disease severity, and high BSI score. Neither comorbidities nor BE aetiology appeared to affect QoL. Reduced physical capacity correlated with dyspnoea and severe disease.Study registration University of Helsinki, Faculty of Medicine, 148/16.08.2017. |
| first_indexed | 2024-04-12T10:09:41Z |
| format | Article |
| id | doaj.art-26b814cd4d14437cad4f576e88533716 |
| institution | Directory Open Access Journal |
| issn | 2001-8525 |
| language | English |
| last_indexed | 2024-04-12T10:09:41Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | European Clinical Respiratory Journal |
| spelling | doaj.art-26b814cd4d14437cad4f576e885337162022-12-22T03:37:21ZengTaylor & Francis GroupEuropean Clinical Respiratory Journal2001-85252022-12-019110.1080/20018525.2022.2095104In bronchiectasis, poor physical capacity correlates with poor quality of lifeJarkko Mäntylä0Witold Mazur1Tanja Törölä2Paula Bergman3Paula Kauppi4University of Helsinki and Helsinki University Hospital, Heart and Lung Center, Department of Respiratory Diseases, Espoo, FinlandUniversity of Helsinki and Helsinki University Hospital, Heart and Lung Center, Department of Respiratory Diseases, Espoo, FinlandUniversity of Helsinki and Helsinki University Hospital, Inflammation Center, Department of Allergy, Espoo, FinlandUniversity of Helsinki, Biostatistics Consulting, Department of Public Health, University of Helsinki, Espoo, FinlandUniversity of Helsinki and Helsinki University Hospital, Heart and Lung Center, Department of Respiratory Diseases, Espoo, FinlandPurpose Patients with bronchiectasis (BE) who suffer frequent exacerbations are likely to experience negative effects on quality of life (QoL) and require more healthcare utilization. We aimed to discover, in a cohort of Finnish BE patients, those risk factors that influence QoL.Methods Non-cystic fibrosis BE patients of a Helsinki University Hospital cohort were examined with high-resolution computed tomography (HRCT) of the chest. They completed a disease-specific quality of life-bronchiectasis (QoL-B) questionnaire in Finnish translation. We considered scores in the lowest quarter (25%) of that QoL-B scale to indicate poor QoL. The bronchiectasis severity index (BSI), FACED score, and modified Medical Research Council (mMRC) dyspnoea scale were used.Results Overall, of 95 adult BE patients, mean age was 69 (SD ± 13) and 79% were women. From the cohort, 82% presented with chronic sputum production and exacerbations, at a median rate of 1.7 (SD ± 1.6). The number of exacerbations (OR 1.7), frequent exacerbations (≥3 per year) (OR 4.9), high BSI score (OR 1.3), and extensive disease (≥3 lobes) (OR 3.7) were all predictive of poor QoL. Frequent exacerbations were associated with bronchial bacterial colonisation, low forced expiratory volume in 1 s (FEV1), and radiological disease severity. Based on the BSI, 34.1% of our cohort had severe disease, with 11.6% classified as severe according to their FACED score. The mMRC dyspnoea score (r = −0.57) and BSI (r = −0.60) correlated, in the QoL-B questionnaire, negatively with physical domain.Conclusion The strongest determinants of poor QoL in the cohort of Finnish BE patients were frequent exacerbations, radiological disease severity, and high BSI score. Neither comorbidities nor BE aetiology appeared to affect QoL. Reduced physical capacity correlated with dyspnoea and severe disease.Study registration University of Helsinki, Faculty of Medicine, 148/16.08.2017.https://www.tandfonline.com/doi/10.1080/20018525.2022.2095104Bronchiectasisbronchiectasis severity indexquality of lifeextensive diseaseexacerbation |
| spellingShingle | Jarkko Mäntylä Witold Mazur Tanja Törölä Paula Bergman Paula Kauppi In bronchiectasis, poor physical capacity correlates with poor quality of life European Clinical Respiratory Journal Bronchiectasis bronchiectasis severity index quality of life extensive disease exacerbation |
| title | In bronchiectasis, poor physical capacity correlates with poor quality of life |
| title_full | In bronchiectasis, poor physical capacity correlates with poor quality of life |
| title_fullStr | In bronchiectasis, poor physical capacity correlates with poor quality of life |
| title_full_unstemmed | In bronchiectasis, poor physical capacity correlates with poor quality of life |
| title_short | In bronchiectasis, poor physical capacity correlates with poor quality of life |
| title_sort | in bronchiectasis poor physical capacity correlates with poor quality of life |
| topic | Bronchiectasis bronchiectasis severity index quality of life extensive disease exacerbation |
| url | https://www.tandfonline.com/doi/10.1080/20018525.2022.2095104 |
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