Proteolytic single hinge cleavage of pertuzumab impairs its Fc effector function and antitumor activity in vitro and in vivo

Proteolytic single hinge cleavage of pertuzumab impairs its Fc effector function and antitumor activity in vitro and in vivo

Abstract Background Proteolytic impairment of the Fc effector functions of therapeutic monoclonal antibodies (mAbs) can compromise their antitumor efficacy in the tumor microenvironment and may represent an unappreciated mechanism of host immune evasion. Pertuzumab is a human epidermal growth factor...

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Bibliographic Details
Main Authors: Hao-Ching Hsiao, Xuejun Fan, Robert E. Jordan, Ningyan Zhang, Zhiqiang An
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Breast Cancer Research
Subjects:
Pertuzumab
HER2
Antibody hinge cleavage
Fc effector function
Breast cancer
Tumor invasion of humoral immunity
Online Access:http://link.springer.com/article/10.1186/s13058-018-0972-4

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