Progress of Immune Checkpoint Inhibitors in the Treatment of Advanced Pulmonary Neuroendocrine Tumors
Pulmonary neuroendocrine tumors (PNETs) are a kind of epithelial tumors originating from pulmonary neuroendocrine cells, accounting for about 20% of primary lung tumors, including typical carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma. The morphologic an...
| Main Authors: | , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2021-11-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2021.102.42 |
| _version_ | 1830360265783246848 |
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| author | Haoqing CHEN Qingwei MENG |
| author_facet | Haoqing CHEN Qingwei MENG |
| author_sort | Haoqing CHEN |
| collection | DOAJ |
| description | Pulmonary neuroendocrine tumors (PNETs) are a kind of epithelial tumors originating from pulmonary neuroendocrine cells, accounting for about 20% of primary lung tumors, including typical carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma. The morphologic and clinical characteristics of these four types of PNETs are relatively highly heterogeneous. Immune checkpoint inhibitors (ICIs) have been shown robust antitumor activity in a variety of solid tumors. Treatment regimens of advanced PNETs have developed greatly in the past decade, but ICIs are still in their infancy in the field of PNETs. This review focuses on the landscape of current clinical trials and research as well as the situation of ICIs-related biomarkers in PNETs. |
| first_indexed | 2024-12-20T03:15:06Z |
| format | Article |
| id | doaj.art-26b9b02e228d4918919f3705659d635d |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-20T03:15:06Z |
| publishDate | 2021-11-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-26b9b02e228d4918919f3705659d635d2022-12-21T19:55:22ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872021-11-01241178478910.3779/j.issn.1009-3419.2021.102.42Progress of Immune Checkpoint Inhibitors
in the Treatment of Advanced Pulmonary Neuroendocrine TumorsHaoqing CHEN0Qingwei MENG1Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin 150000, ChinaDepartment of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin 150000, ChinaPulmonary neuroendocrine tumors (PNETs) are a kind of epithelial tumors originating from pulmonary neuroendocrine cells, accounting for about 20% of primary lung tumors, including typical carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma. The morphologic and clinical characteristics of these four types of PNETs are relatively highly heterogeneous. Immune checkpoint inhibitors (ICIs) have been shown robust antitumor activity in a variety of solid tumors. Treatment regimens of advanced PNETs have developed greatly in the past decade, but ICIs are still in their infancy in the field of PNETs. This review focuses on the landscape of current clinical trials and research as well as the situation of ICIs-related biomarkers in PNETs.http://dx.doi.org/10.3779/j.issn.1009-3419.2021.102.42pulmonary neuroendocrine tumorsimmune checkpoint inhibitorsbiomarkersimmnotherapy |
| spellingShingle | Haoqing CHEN Qingwei MENG Progress of Immune Checkpoint Inhibitors in the Treatment of Advanced Pulmonary Neuroendocrine Tumors Chinese Journal of Lung Cancer pulmonary neuroendocrine tumors immune checkpoint inhibitors biomarkers immnotherapy |
| title | Progress of Immune Checkpoint Inhibitors
in the Treatment of Advanced Pulmonary Neuroendocrine Tumors |
| title_full | Progress of Immune Checkpoint Inhibitors
in the Treatment of Advanced Pulmonary Neuroendocrine Tumors |
| title_fullStr | Progress of Immune Checkpoint Inhibitors
in the Treatment of Advanced Pulmonary Neuroendocrine Tumors |
| title_full_unstemmed | Progress of Immune Checkpoint Inhibitors
in the Treatment of Advanced Pulmonary Neuroendocrine Tumors |
| title_short | Progress of Immune Checkpoint Inhibitors
in the Treatment of Advanced Pulmonary Neuroendocrine Tumors |
| title_sort | progress of immune checkpoint inhibitors
in the treatment of advanced pulmonary neuroendocrine tumors |
| topic | pulmonary neuroendocrine tumors immune checkpoint inhibitors biomarkers immnotherapy |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2021.102.42 |
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