Oxidative Stress-Induced Hypertension of Developmental Origins: Preventive Aspects of Antioxidant Therapy
Hypertension remains the leading cause of disease burden worldwide. Hypertension can originate in the early stages of life. A growing body of evidence suggests that oxidative stress, which is characterized as a reactive oxygen species (ROS)/nitric oxide (NO) disequilibrium, has a pivotal role in the...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/11/3/511 |
| _version_ | 1797473194330816512 |
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| author | You-Lin Tain Chien-Ning Hsu |
| author_facet | You-Lin Tain Chien-Ning Hsu |
| author_sort | You-Lin Tain |
| collection | DOAJ |
| description | Hypertension remains the leading cause of disease burden worldwide. Hypertension can originate in the early stages of life. A growing body of evidence suggests that oxidative stress, which is characterized as a reactive oxygen species (ROS)/nitric oxide (NO) disequilibrium, has a pivotal role in the hypertension of developmental origins. Results from animal studies support the idea that early-life oxidative stress causes developmental programming in prime blood pressure (BP)-controlled organs such as the brain, kidneys, heart, and blood vessels, leading to hypertension in adult offspring. Conversely, perinatal use of antioxidants can counteract oxidative stress and therefore lower BP. This review discusses the interaction between oxidative stress and developmental programming in hypertension. It will also discuss evidence from animal models, how oxidative stress connects with other core mechanisms, and the potential of antioxidant therapy as a novel preventive strategy to prevent the hypertension of developmental origins. |
| first_indexed | 2024-03-09T20:11:23Z |
| format | Article |
| id | doaj.art-26bcaab3948f4631b6ec16c157b44065 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T20:11:23Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-26bcaab3948f4631b6ec16c157b440652023-11-24T00:13:19ZengMDPI AGAntioxidants2076-39212022-03-0111351110.3390/antiox11030511Oxidative Stress-Induced Hypertension of Developmental Origins: Preventive Aspects of Antioxidant TherapyYou-Lin Tain0Chien-Ning Hsu1Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, TaiwanHypertension remains the leading cause of disease burden worldwide. Hypertension can originate in the early stages of life. A growing body of evidence suggests that oxidative stress, which is characterized as a reactive oxygen species (ROS)/nitric oxide (NO) disequilibrium, has a pivotal role in the hypertension of developmental origins. Results from animal studies support the idea that early-life oxidative stress causes developmental programming in prime blood pressure (BP)-controlled organs such as the brain, kidneys, heart, and blood vessels, leading to hypertension in adult offspring. Conversely, perinatal use of antioxidants can counteract oxidative stress and therefore lower BP. This review discusses the interaction between oxidative stress and developmental programming in hypertension. It will also discuss evidence from animal models, how oxidative stress connects with other core mechanisms, and the potential of antioxidant therapy as a novel preventive strategy to prevent the hypertension of developmental origins.https://www.mdpi.com/2076-3921/11/3/511antioxidanthypertensionnitric oxideasymmetric dimethylarginineoxidative stressdevelopmental origins of health and disease (DOHaD) |
| spellingShingle | You-Lin Tain Chien-Ning Hsu Oxidative Stress-Induced Hypertension of Developmental Origins: Preventive Aspects of Antioxidant Therapy Antioxidants antioxidant hypertension nitric oxide asymmetric dimethylarginine oxidative stress developmental origins of health and disease (DOHaD) |
| title | Oxidative Stress-Induced Hypertension of Developmental Origins: Preventive Aspects of Antioxidant Therapy |
| title_full | Oxidative Stress-Induced Hypertension of Developmental Origins: Preventive Aspects of Antioxidant Therapy |
| title_fullStr | Oxidative Stress-Induced Hypertension of Developmental Origins: Preventive Aspects of Antioxidant Therapy |
| title_full_unstemmed | Oxidative Stress-Induced Hypertension of Developmental Origins: Preventive Aspects of Antioxidant Therapy |
| title_short | Oxidative Stress-Induced Hypertension of Developmental Origins: Preventive Aspects of Antioxidant Therapy |
| title_sort | oxidative stress induced hypertension of developmental origins preventive aspects of antioxidant therapy |
| topic | antioxidant hypertension nitric oxide asymmetric dimethylarginine oxidative stress developmental origins of health and disease (DOHaD) |
| url | https://www.mdpi.com/2076-3921/11/3/511 |
| work_keys_str_mv | AT youlintain oxidativestressinducedhypertensionofdevelopmentaloriginspreventiveaspectsofantioxidanttherapy AT chienninghsu oxidativestressinducedhypertensionofdevelopmentaloriginspreventiveaspectsofantioxidanttherapy |