Histomorphological and immunophenotypic diagnoses of gastrointestinal stromal tumors and other sarcomas that affect the intestine of dogs
In view of the morphological similarity between gastrointestinal stromal tumors (GIST) and other sarcomas of the intestine of dogs, the aim was to carry out the histomorphological and immunohistochemical diagnosis of these tumors, associating breed, sex and age, location and tumor invasion. 217 cas...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Universidade Federal de Goiás
2023-09-01
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| Series: | Ciência Animal Brasileira |
| Online Access: | https://revistas.ufg.br/vet/article/view/75610 |
| _version_ | 1797692920069881856 |
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| author | Marina Laudares Costa Felipe Augusto Ruiz Sueiro Paulo César Jark Leonardo Lamarca de Carvalho Marcela Aldrovani Rodrigues Vinícius Thomaz da Silva Almeida Fernanda Gosuen Gonçalves Dias |
| author_facet | Marina Laudares Costa Felipe Augusto Ruiz Sueiro Paulo César Jark Leonardo Lamarca de Carvalho Marcela Aldrovani Rodrigues Vinícius Thomaz da Silva Almeida Fernanda Gosuen Gonçalves Dias |
| author_sort | Marina Laudares Costa |
| collection | DOAJ |
| description |
In view of the morphological similarity between gastrointestinal stromal tumors (GIST) and other sarcomas of the intestine of dogs, the aim was to carry out the histomorphological and immunohistochemical diagnosis of these tumors, associating breed, sex and age, location and tumor invasion. 217 cases were evaluated by histopathology and 36 diagnosed by immunohistochemistry were included (24 GIST and 12 other intestinal sarcomas). Mixed breed dogs were the most diagnosed with GIST, mainly elderly females (9.5±2.2 years); in the other intestinal sarcomas, crossbreeds and Dachshunds, males and females, were equally affected. The cecum was the most affected by GISTs, with tumor invasion of the intestinal layers in all cases. The small intestine was the most affected by the other intestinal sarcomas, with invasion of the layers in most of these tumors. GISTs expressed markers such as CD117 and DOG-1, unlike other intestinal sarcomas. GIST and other intestinal sarcomas denoted histomorphological and immunophenotypic characteristics similar to histopathology, justifying the association of immunohistochemistry for the definitive diagnosis.
Keywords: CD117; DOG-1; GIST; veterinary oncology
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| first_indexed | 2024-03-12T02:34:30Z |
| format | Article |
| id | doaj.art-26bcc1e2685c41ba9b948153e998a818 |
| institution | Directory Open Access Journal |
| issn | 1518-2797 1809-6891 |
| language | English |
| last_indexed | 2024-03-12T02:34:30Z |
| publishDate | 2023-09-01 |
| publisher | Universidade Federal de Goiás |
| record_format | Article |
| series | Ciência Animal Brasileira |
| spelling | doaj.art-26bcc1e2685c41ba9b948153e998a8182023-09-04T21:06:32ZengUniversidade Federal de GoiásCiência Animal Brasileira1518-27971809-68912023-09-0124Histomorphological and immunophenotypic diagnoses of gastrointestinal stromal tumors and other sarcomas that affect the intestine of dogsMarina Laudares Costa0Felipe Augusto Ruiz Sueiro1Paulo César Jark2Leonardo Lamarca de Carvalho3Marcela Aldrovani Rodrigues4Vinícius Thomaz da Silva Almeida5Fernanda Gosuen Gonçalves Dias6Universidade de Franca (UNIFRAN), Franca, São Paulo, BrazilVETPAT Clinical Analysis Laboratory, Campinas, SP, Brazil3Oncospes Oncology Service, Ribeirão Preto, São Paulo, BrazilUniversidade de Franca (UNIFRAN), Franca, São Paulo, BrazilUniversidade de Franca (UNIFRAN), Franca, São Paulo, BrazilUniversidade de Franca (UNIFRAN), Franca, São Paulo, BrazilUniversidade de Franca (UNIFRAN), Franca, São Paulo, Brazil In view of the morphological similarity between gastrointestinal stromal tumors (GIST) and other sarcomas of the intestine of dogs, the aim was to carry out the histomorphological and immunohistochemical diagnosis of these tumors, associating breed, sex and age, location and tumor invasion. 217 cases were evaluated by histopathology and 36 diagnosed by immunohistochemistry were included (24 GIST and 12 other intestinal sarcomas). Mixed breed dogs were the most diagnosed with GIST, mainly elderly females (9.5±2.2 years); in the other intestinal sarcomas, crossbreeds and Dachshunds, males and females, were equally affected. The cecum was the most affected by GISTs, with tumor invasion of the intestinal layers in all cases. The small intestine was the most affected by the other intestinal sarcomas, with invasion of the layers in most of these tumors. GISTs expressed markers such as CD117 and DOG-1, unlike other intestinal sarcomas. GIST and other intestinal sarcomas denoted histomorphological and immunophenotypic characteristics similar to histopathology, justifying the association of immunohistochemistry for the definitive diagnosis. Keywords: CD117; DOG-1; GIST; veterinary oncology https://revistas.ufg.br/vet/article/view/75610 |
| spellingShingle | Marina Laudares Costa Felipe Augusto Ruiz Sueiro Paulo César Jark Leonardo Lamarca de Carvalho Marcela Aldrovani Rodrigues Vinícius Thomaz da Silva Almeida Fernanda Gosuen Gonçalves Dias Histomorphological and immunophenotypic diagnoses of gastrointestinal stromal tumors and other sarcomas that affect the intestine of dogs Ciência Animal Brasileira |
| title | Histomorphological and immunophenotypic diagnoses of gastrointestinal stromal tumors and other sarcomas that affect the intestine of dogs |
| title_full | Histomorphological and immunophenotypic diagnoses of gastrointestinal stromal tumors and other sarcomas that affect the intestine of dogs |
| title_fullStr | Histomorphological and immunophenotypic diagnoses of gastrointestinal stromal tumors and other sarcomas that affect the intestine of dogs |
| title_full_unstemmed | Histomorphological and immunophenotypic diagnoses of gastrointestinal stromal tumors and other sarcomas that affect the intestine of dogs |
| title_short | Histomorphological and immunophenotypic diagnoses of gastrointestinal stromal tumors and other sarcomas that affect the intestine of dogs |
| title_sort | histomorphological and immunophenotypic diagnoses of gastrointestinal stromal tumors and other sarcomas that affect the intestine of dogs |
| url | https://revistas.ufg.br/vet/article/view/75610 |
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