Low postoperative blood platelet count may be a risk factor for 3-year mortality in patients with acute type A aortic dissection
Abstract Background Mortality and complications remain high after acute type A aortic dissection (ATAAD) open surgery and are associated with coagulation dysfunction. Platelets play an important role in the process of coagulation. This study explored the relationship between postoperative platelet c...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-09-01
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| Series: | Journal of Cardiothoracic Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13019-021-01623-7 |
| _version_ | 1818691470415101952 |
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| author | Guangyu Liu Hongbai Wang Qipeng Luo Liang Cao Lijing Yang Cuntao Yu Fuxia Yan Su Yuan |
| author_facet | Guangyu Liu Hongbai Wang Qipeng Luo Liang Cao Lijing Yang Cuntao Yu Fuxia Yan Su Yuan |
| author_sort | Guangyu Liu |
| collection | DOAJ |
| description | Abstract Background Mortality and complications remain high after acute type A aortic dissection (ATAAD) open surgery and are associated with coagulation dysfunction. Platelets play an important role in the process of coagulation. This study explored the relationship between postoperative platelet counts and 3-year mortality after operation in patients with ATAAD undergoing open aortic repair surgery. Methods Patients with ATAAD who underwent Total Arch Replacement and Frozen Elephant Trunk in Fuwai Hospital from 2011 to 2015 were selected for this study. The perioperative data were collected and sorted through the electronic clinical case system. Multivariate Logistic regression was used to analyze the risk factors for death within three years after surgery. Results A total of 495 patients were included in the analysis. After correction for confounding factors, decreased postoperative platelet count remained an independent factor that was associated with lower mortality (OR = 0.918, 95% CI 0.853–0.988, P = 0.023). Conclusions The study indicated that decreased postoperative platelet count may lead to increased 3-year mortality, in patients with ATAAD who underwent open aortic repair surgery. |
| first_indexed | 2024-12-17T12:42:24Z |
| format | Article |
| id | doaj.art-26bda14b99c24e079a50e3ce2411690e |
| institution | Directory Open Access Journal |
| issn | 1749-8090 |
| language | English |
| last_indexed | 2024-12-17T12:42:24Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj.art-26bda14b99c24e079a50e3ce2411690e2022-12-21T21:47:55ZengBMCJournal of Cardiothoracic Surgery1749-80902021-09-011611710.1186/s13019-021-01623-7Low postoperative blood platelet count may be a risk factor for 3-year mortality in patients with acute type A aortic dissectionGuangyu Liu0Hongbai Wang1Qipeng Luo2Liang Cao3Lijing Yang4Cuntao Yu5Fuxia Yan6Su Yuan7Anesthesia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAnesthesia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegePain Medicine Center, Peking University Third HospitalAnesthesia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAnesthesia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeVascular Surgery Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAnesthesia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAnesthesia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract Background Mortality and complications remain high after acute type A aortic dissection (ATAAD) open surgery and are associated with coagulation dysfunction. Platelets play an important role in the process of coagulation. This study explored the relationship between postoperative platelet counts and 3-year mortality after operation in patients with ATAAD undergoing open aortic repair surgery. Methods Patients with ATAAD who underwent Total Arch Replacement and Frozen Elephant Trunk in Fuwai Hospital from 2011 to 2015 were selected for this study. The perioperative data were collected and sorted through the electronic clinical case system. Multivariate Logistic regression was used to analyze the risk factors for death within three years after surgery. Results A total of 495 patients were included in the analysis. After correction for confounding factors, decreased postoperative platelet count remained an independent factor that was associated with lower mortality (OR = 0.918, 95% CI 0.853–0.988, P = 0.023). Conclusions The study indicated that decreased postoperative platelet count may lead to increased 3-year mortality, in patients with ATAAD who underwent open aortic repair surgery.https://doi.org/10.1186/s13019-021-01623-7Aortic diseasesBlood plateletsVascular surgical proceduresAortic replacement |
| spellingShingle | Guangyu Liu Hongbai Wang Qipeng Luo Liang Cao Lijing Yang Cuntao Yu Fuxia Yan Su Yuan Low postoperative blood platelet count may be a risk factor for 3-year mortality in patients with acute type A aortic dissection Journal of Cardiothoracic Surgery Aortic diseases Blood platelets Vascular surgical procedures Aortic replacement |
| title | Low postoperative blood platelet count may be a risk factor for 3-year mortality in patients with acute type A aortic dissection |
| title_full | Low postoperative blood platelet count may be a risk factor for 3-year mortality in patients with acute type A aortic dissection |
| title_fullStr | Low postoperative blood platelet count may be a risk factor for 3-year mortality in patients with acute type A aortic dissection |
| title_full_unstemmed | Low postoperative blood platelet count may be a risk factor for 3-year mortality in patients with acute type A aortic dissection |
| title_short | Low postoperative blood platelet count may be a risk factor for 3-year mortality in patients with acute type A aortic dissection |
| title_sort | low postoperative blood platelet count may be a risk factor for 3 year mortality in patients with acute type a aortic dissection |
| topic | Aortic diseases Blood platelets Vascular surgical procedures Aortic replacement |
| url | https://doi.org/10.1186/s13019-021-01623-7 |
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