Activation of PERK Contributes to Apoptosis and G<sub>2</sub>/M Arrest by Microtubule Disruptors in Human Colorectal Carcinoma Cells

Activation of PERK Contributes to Apoptosis and G<sub>2</sub>/M Arrest by Microtubule Disruptors in Human Colorectal Carcinoma Cells

Microtubule-targeting agents (MTAs) are widely used in cancer chemotherapy, but the therapeutic responses significantly vary among different tumor types. Protein kinase RNA-like endoplasmic reticular (ER) kinase (PERK) is an ER stress kinase, and the role of PERK in the anticancer effects of MTAs is...

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Bibliographic Details
Main Authors: Ming-Shun Wu, Chih-Chiang Chien, Ganbolor Jargalsaikhan, Noor Andryan Ilsan, Yen-Chou Chen
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Cancers
Subjects:
protein kinase rna-like endoplasmic reticular kinase
microtubule disrupters
taxol
nocodazole
human colon carcinoma cells
Online Access:https://www.mdpi.com/2072-6694/12/1/97

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https://www.mdpi.com/2072-6694/12/1/97

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