Metabolic disorders and risk of cardiovascular diseases: a two-sample mendelian randomization study
Abstract Background Metabolic disorders are increasing worldwide and are characterized by various risk factors such as abdominal obesity, insulin resistance, impaired glucose metabolism, and dyslipidemia. Observational studies suggested a bidirectional association between cardiovascular diseases and...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-023-03567-3 |
| _version_ | 1797637092873863168 |
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| author | Zhe Wang Jiawei Chen Longyang Zhu Siqi Jiao Yinong Chen Yihong Sun |
| author_facet | Zhe Wang Jiawei Chen Longyang Zhu Siqi Jiao Yinong Chen Yihong Sun |
| author_sort | Zhe Wang |
| collection | DOAJ |
| description | Abstract Background Metabolic disorders are increasing worldwide and are characterized by various risk factors such as abdominal obesity, insulin resistance, impaired glucose metabolism, and dyslipidemia. Observational studies suggested a bidirectional association between cardiovascular diseases and metabolic disorders and its components. However, the causal associations between them remained unclear. This study aims to investigate the causal relationship between metabolic disorders and cardiovascular disease through Mendelian randomization (MR) analysis. Methods A two-sample MR analysis based on publicly available genome-wide association studies were used to infer the causality. The single-nucleotide polymorphisms with potential pleiotropy were excluded by MR-PRESSO. The effect estimates were constructed using the random-effects inverse-variance-weighted method as the primary estimate. Furthermore, MR-Egger and weighted median were also performed to detect heterogeneity and pleiotropy. Results Genetically predicted metabolic disorders increased the risk for coronary heart disease (OR = 1.77, 95% CI: 1.55–2.03, p < 0.001), myocardial infarction (OR = 1.75, 95% CI: 1.52–2.03, p < 0.001), heart failure (OR = 1.26, 95% CI: 1.14–1.39, p < 0.001), hypertension (OR = 1.01, 95% CI: 1.00-1.02, p = 0.002), and stroke (OR = 1.19, 95% CI: 1.08–1.32, p < 0.001). The concordance of the results of various complementary sensitivity MR methods reinforces the causal relationship further. Conclusion This study provides evidence of a causal relationship between metabolic disorders and increased risk of coronary heart disease, myocardial infarction, heart failure, hypertension, and stroke. Special attention should be paid to improving metabolic disorders to reduce the development of cardiovascular diseases. |
| first_indexed | 2024-03-11T12:43:27Z |
| format | Article |
| id | doaj.art-26be0b3595d140cda6c94ab324f6c386 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-03-11T12:43:27Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-26be0b3595d140cda6c94ab324f6c3862023-11-05T12:07:20ZengBMCBMC Cardiovascular Disorders1471-22612023-10-012311810.1186/s12872-023-03567-3Metabolic disorders and risk of cardiovascular diseases: a two-sample mendelian randomization studyZhe Wang0Jiawei Chen1Longyang Zhu2Siqi Jiao3Yinong Chen4Yihong Sun5Department of Cardiology, China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Chinese Academy of Medical Sciences & Peking Union Medical CollegeDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Cardiology, Peking University China-Japan Friendship School of Clinical MedicineDepartment of Cardiology, Peking University China-Japan Friendship School of Clinical MedicineDepartment of Cardiology, Peking University China-Japan Friendship School of Clinical MedicineDepartment of Cardiology, China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Chinese Academy of Medical Sciences & Peking Union Medical CollegeAbstract Background Metabolic disorders are increasing worldwide and are characterized by various risk factors such as abdominal obesity, insulin resistance, impaired glucose metabolism, and dyslipidemia. Observational studies suggested a bidirectional association between cardiovascular diseases and metabolic disorders and its components. However, the causal associations between them remained unclear. This study aims to investigate the causal relationship between metabolic disorders and cardiovascular disease through Mendelian randomization (MR) analysis. Methods A two-sample MR analysis based on publicly available genome-wide association studies were used to infer the causality. The single-nucleotide polymorphisms with potential pleiotropy were excluded by MR-PRESSO. The effect estimates were constructed using the random-effects inverse-variance-weighted method as the primary estimate. Furthermore, MR-Egger and weighted median were also performed to detect heterogeneity and pleiotropy. Results Genetically predicted metabolic disorders increased the risk for coronary heart disease (OR = 1.77, 95% CI: 1.55–2.03, p < 0.001), myocardial infarction (OR = 1.75, 95% CI: 1.52–2.03, p < 0.001), heart failure (OR = 1.26, 95% CI: 1.14–1.39, p < 0.001), hypertension (OR = 1.01, 95% CI: 1.00-1.02, p = 0.002), and stroke (OR = 1.19, 95% CI: 1.08–1.32, p < 0.001). The concordance of the results of various complementary sensitivity MR methods reinforces the causal relationship further. Conclusion This study provides evidence of a causal relationship between metabolic disorders and increased risk of coronary heart disease, myocardial infarction, heart failure, hypertension, and stroke. Special attention should be paid to improving metabolic disorders to reduce the development of cardiovascular diseases.https://doi.org/10.1186/s12872-023-03567-3Metabolic disordersCardiovascular diseasesMendelian randomization analysis |
| spellingShingle | Zhe Wang Jiawei Chen Longyang Zhu Siqi Jiao Yinong Chen Yihong Sun Metabolic disorders and risk of cardiovascular diseases: a two-sample mendelian randomization study BMC Cardiovascular Disorders Metabolic disorders Cardiovascular diseases Mendelian randomization analysis |
| title | Metabolic disorders and risk of cardiovascular diseases: a two-sample mendelian randomization study |
| title_full | Metabolic disorders and risk of cardiovascular diseases: a two-sample mendelian randomization study |
| title_fullStr | Metabolic disorders and risk of cardiovascular diseases: a two-sample mendelian randomization study |
| title_full_unstemmed | Metabolic disorders and risk of cardiovascular diseases: a two-sample mendelian randomization study |
| title_short | Metabolic disorders and risk of cardiovascular diseases: a two-sample mendelian randomization study |
| title_sort | metabolic disorders and risk of cardiovascular diseases a two sample mendelian randomization study |
| topic | Metabolic disorders Cardiovascular diseases Mendelian randomization analysis |
| url | https://doi.org/10.1186/s12872-023-03567-3 |
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