A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs
Notch signaling is known to control neuroendocrine fate in the lungs. Shue and colleagues further identify the REST and YAP transcriptional regulators as key components of the Notch signaling pathway in the control of the neuroendocrine cell fate in lung development, lung injury response, and small-...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30416-2 |
| _version_ | 1811255024156672000 |
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| author | Yan Ting Shue Alexandros P. Drainas Nancy Yanzhe Li Sarah M. Pearsall Derrick Morgan Nasa Sinnott-Armstrong Susan Q. Hipkins Garry L. Coles Jing Shan Lim Anthony E. Oro Kathryn L. Simpson Caroline Dive Julien Sage |
| author_facet | Yan Ting Shue Alexandros P. Drainas Nancy Yanzhe Li Sarah M. Pearsall Derrick Morgan Nasa Sinnott-Armstrong Susan Q. Hipkins Garry L. Coles Jing Shan Lim Anthony E. Oro Kathryn L. Simpson Caroline Dive Julien Sage |
| author_sort | Yan Ting Shue |
| collection | DOAJ |
| description | Notch signaling is known to control neuroendocrine fate in the lungs. Shue and colleagues further identify the REST and YAP transcriptional regulators as key components of the Notch signaling pathway in the control of the neuroendocrine cell fate in lung development, lung injury response, and small-cell lung cancer. |
| first_indexed | 2024-04-12T17:17:31Z |
| format | Article |
| id | doaj.art-26be3ba323444a888bbc657c28aa7b6e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T17:17:31Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-26be3ba323444a888bbc657c28aa7b6e2022-12-22T03:23:35ZengNature PortfolioNature Communications2041-17232022-05-0113111810.1038/s41467-022-30416-2A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungsYan Ting Shue0Alexandros P. Drainas1Nancy Yanzhe Li2Sarah M. Pearsall3Derrick Morgan4Nasa Sinnott-Armstrong5Susan Q. Hipkins6Garry L. Coles7Jing Shan Lim8Anthony E. Oro9Kathryn L. Simpson10Caroline Dive11Julien Sage12Departments of Pediatrics, Stanford UniversityDepartments of Pediatrics, Stanford UniversityDepartments of Program in Epithelial Biology, Stanford UniversityCancer Research UK Manchester Institute Cancer Biomarker Centre, University of ManchesterCancer Research UK Manchester Institute Cancer Biomarker Centre, University of ManchesterDepartments of Genetics, Stanford UniversityDepartments of Pediatrics, Stanford UniversityDepartments of Pediatrics, Stanford UniversityDepartments of Pediatrics, Stanford UniversityDepartments of Program in Epithelial Biology, Stanford UniversityCancer Research UK Manchester Institute Cancer Biomarker Centre, University of ManchesterCancer Research UK Manchester Institute Cancer Biomarker Centre, University of ManchesterDepartments of Pediatrics, Stanford UniversityNotch signaling is known to control neuroendocrine fate in the lungs. Shue and colleagues further identify the REST and YAP transcriptional regulators as key components of the Notch signaling pathway in the control of the neuroendocrine cell fate in lung development, lung injury response, and small-cell lung cancer.https://doi.org/10.1038/s41467-022-30416-2 |
| spellingShingle | Yan Ting Shue Alexandros P. Drainas Nancy Yanzhe Li Sarah M. Pearsall Derrick Morgan Nasa Sinnott-Armstrong Susan Q. Hipkins Garry L. Coles Jing Shan Lim Anthony E. Oro Kathryn L. Simpson Caroline Dive Julien Sage A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs Nature Communications |
| title | A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs |
| title_full | A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs |
| title_fullStr | A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs |
| title_full_unstemmed | A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs |
| title_short | A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs |
| title_sort | conserved yap notch rest network controls the neuroendocrine cell fate in the lungs |
| url | https://doi.org/10.1038/s41467-022-30416-2 |
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