Validação de método analítico por espectrofotometria UV para sistema emulsionado lipídico contendo benznidazol
A validation study of an UV spectrophotometric method was conducted for quantitative analysis of benznidazol (BZN) in a lipid. The analytical determinations were performed at 315 nm at 25 ºC. The emulsion components did not interfere on drug analyses, demonstrating the specificity of the methodology...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2011-01-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000800028&lng=en&tlng=en |
| _version_ | 1817984609924677632 |
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| author | Letícia Streck Kátia Solange Cardoso Rodrigues dos Santos Matheus de Freitas Fernandes-Pedrosa Arnóbio Antônio da Silva-Júnior Anselmo Gomes de Oliveira |
| author_facet | Letícia Streck Kátia Solange Cardoso Rodrigues dos Santos Matheus de Freitas Fernandes-Pedrosa Arnóbio Antônio da Silva-Júnior Anselmo Gomes de Oliveira |
| author_sort | Letícia Streck |
| collection | DOAJ |
| description | A validation study of an UV spectrophotometric method was conducted for quantitative analysis of benznidazol (BZN) in a lipid. The analytical determinations were performed at 315 nm at 25 ºC. The emulsion components did not interfere on drug analyses, demonstrating the specificity of the methodology. A good linearity (r = 0.99995) and precision (RSD < 5.0%) for intra and inter-day studies, including the reproducibility test were observed. The accuracy ranged of 102.1 + 2.8 e 103.8 + 1.7%. The statistical analysis demonstrates a linear, precise, accurate and robust method for BZN quantification from the lipid emulsion system. |
| first_indexed | 2024-04-13T23:46:55Z |
| format | Article |
| id | doaj.art-26be643a2b0342dc8325abcff7db1a96 |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-04-13T23:46:55Z |
| publishDate | 2011-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-26be643a2b0342dc8325abcff7db1a962022-12-22T02:24:16ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642011-01-013481459146310.1590/S0100-40422011000800028S0100-40422011000800028Validação de método analítico por espectrofotometria UV para sistema emulsionado lipídico contendo benznidazolLetícia Streck0Kátia Solange Cardoso Rodrigues dos Santos1Matheus de Freitas Fernandes-Pedrosa2Arnóbio Antônio da Silva-Júnior3Anselmo Gomes de Oliveira4Universidade Federal do Rio Grande do NorteUniversidade Federal do Rio Grande do NorteUniversidade Federal do Rio Grande do NorteUniversidade Federal do Rio Grande do NorteUniversidade Estadual PaulistaA validation study of an UV spectrophotometric method was conducted for quantitative analysis of benznidazol (BZN) in a lipid. The analytical determinations were performed at 315 nm at 25 ºC. The emulsion components did not interfere on drug analyses, demonstrating the specificity of the methodology. A good linearity (r = 0.99995) and precision (RSD < 5.0%) for intra and inter-day studies, including the reproducibility test were observed. The accuracy ranged of 102.1 + 2.8 e 103.8 + 1.7%. The statistical analysis demonstrates a linear, precise, accurate and robust method for BZN quantification from the lipid emulsion system.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000800028&lng=en&tlng=enbenznidazollipid emulsionsUV-Vis spectrophotometry |
| spellingShingle | Letícia Streck Kátia Solange Cardoso Rodrigues dos Santos Matheus de Freitas Fernandes-Pedrosa Arnóbio Antônio da Silva-Júnior Anselmo Gomes de Oliveira Validação de método analítico por espectrofotometria UV para sistema emulsionado lipídico contendo benznidazol Química Nova benznidazol lipid emulsions UV-Vis spectrophotometry |
| title | Validação de método analítico por espectrofotometria UV para sistema emulsionado lipídico contendo benznidazol |
| title_full | Validação de método analítico por espectrofotometria UV para sistema emulsionado lipídico contendo benznidazol |
| title_fullStr | Validação de método analítico por espectrofotometria UV para sistema emulsionado lipídico contendo benznidazol |
| title_full_unstemmed | Validação de método analítico por espectrofotometria UV para sistema emulsionado lipídico contendo benznidazol |
| title_short | Validação de método analítico por espectrofotometria UV para sistema emulsionado lipídico contendo benznidazol |
| title_sort | validacao de metodo analitico por espectrofotometria uv para sistema emulsionado lipidico contendo benznidazol |
| topic | benznidazol lipid emulsions UV-Vis spectrophotometry |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000800028&lng=en&tlng=en |
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