The role of polymorphism of genes of the I and II phase of xenobiotics biotransformation in the development of recurrent and chronic bronchitis in adolescent-smokers
The purpose of research – to study the role of allelic polymorphism of genes of the I and II phases of xenobiotics biotransformation in the development of reccurent and chronic diseases of the respiratory system in adolescent-smokers. There was carried out molecular-genetic study of the polymorphic...
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| Format: | Article |
| Language: | English |
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Dnipro State Medical University
2017-06-01
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| Series: | Medičnì Perspektivi |
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| Online Access: | http://journals.uran.ua/index.php/2307-0404/article/view/109834 |
| _version_ | 1819001311583010816 |
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| author | S. I. Il'chenko A. А. Fialkovskaia N. N. Kramarenko G. V. Makukh |
| author_facet | S. I. Il'chenko A. А. Fialkovskaia N. N. Kramarenko G. V. Makukh |
| author_sort | S. I. Il'chenko |
| collection | DOAJ |
| description | The purpose of research – to study the role of allelic polymorphism of genes of the I and II phases of xenobiotics biotransformation in the development of reccurent and chronic diseases of the respiratory system in adolescent-smokers. There was carried out molecular-genetic study of the polymorphic locus Т3801С of gene CYP1A1 and polymorphic locus A313G of gene GSTP1 in adolescent-smokers with recurrent and chronic bronchitis. It is established that TТ genotype of the polymorphic locus Т3801С of gene CYP1A is a marker of resistance to the development of this pathology in adolescent-smokers. The presence of CC genotype of the polymorphic locus Т3801С of gene CYP1A1 and GG genotype of polymorphic locus of A313G GSTP1 gene may be considered as a possible risk factor for the development of chronic inflammatory process in bronchopulmonary system. Thus, the introduction of molecular-genetic methods of research opens up new possibilities in diagnosis of recurrent and chronic diseases of the respiratory system. Based on the analysis of genetic factors in children and adolescents, it will be possible to predict the risk of COPD developing in the future;this will allow doctors to carry out the necessary preventive activities among risk groups. |
| first_indexed | 2024-12-20T22:47:12Z |
| format | Article |
| id | doaj.art-26bf7f006906405cbf14a3c30cee6edd |
| institution | Directory Open Access Journal |
| issn | 2307-0404 |
| language | English |
| last_indexed | 2024-12-20T22:47:12Z |
| publishDate | 2017-06-01 |
| publisher | Dnipro State Medical University |
| record_format | Article |
| series | Medičnì Perspektivi |
| spelling | doaj.art-26bf7f006906405cbf14a3c30cee6edd2022-12-21T19:24:20ZengDnipro State Medical UniversityMedičnì Perspektivi2307-04042017-06-01222859010.26641/2307-0404.2017.2.109834109834The role of polymorphism of genes of the I and II phase of xenobiotics biotransformation in the development of recurrent and chronic bronchitis in adolescent-smokersS. I. Il'chenkoA. А. FialkovskaiaN. N. KramarenkoG. V. MakukhThe purpose of research – to study the role of allelic polymorphism of genes of the I and II phases of xenobiotics biotransformation in the development of reccurent and chronic diseases of the respiratory system in adolescent-smokers. There was carried out molecular-genetic study of the polymorphic locus Т3801С of gene CYP1A1 and polymorphic locus A313G of gene GSTP1 in adolescent-smokers with recurrent and chronic bronchitis. It is established that TТ genotype of the polymorphic locus Т3801С of gene CYP1A is a marker of resistance to the development of this pathology in adolescent-smokers. The presence of CC genotype of the polymorphic locus Т3801С of gene CYP1A1 and GG genotype of polymorphic locus of A313G GSTP1 gene may be considered as a possible risk factor for the development of chronic inflammatory process in bronchopulmonary system. Thus, the introduction of molecular-genetic methods of research opens up new possibilities in diagnosis of recurrent and chronic diseases of the respiratory system. Based on the analysis of genetic factors in children and adolescents, it will be possible to predict the risk of COPD developing in the future;this will allow doctors to carry out the necessary preventive activities among risk groups.http://journals.uran.ua/index.php/2307-0404/article/view/109834recurrent and chronic bronchitisadolescent-smokersgene CYP1A1gene GSTP1 |
| spellingShingle | S. I. Il'chenko A. А. Fialkovskaia N. N. Kramarenko G. V. Makukh The role of polymorphism of genes of the I and II phase of xenobiotics biotransformation in the development of recurrent and chronic bronchitis in adolescent-smokers Medičnì Perspektivi recurrent and chronic bronchitis adolescent-smokers gene CYP1A1 gene GSTP1 |
| title | The role of polymorphism of genes of the I and II phase of xenobiotics biotransformation in the development of recurrent and chronic bronchitis in adolescent-smokers |
| title_full | The role of polymorphism of genes of the I and II phase of xenobiotics biotransformation in the development of recurrent and chronic bronchitis in adolescent-smokers |
| title_fullStr | The role of polymorphism of genes of the I and II phase of xenobiotics biotransformation in the development of recurrent and chronic bronchitis in adolescent-smokers |
| title_full_unstemmed | The role of polymorphism of genes of the I and II phase of xenobiotics biotransformation in the development of recurrent and chronic bronchitis in adolescent-smokers |
| title_short | The role of polymorphism of genes of the I and II phase of xenobiotics biotransformation in the development of recurrent and chronic bronchitis in adolescent-smokers |
| title_sort | role of polymorphism of genes of the i and ii phase of xenobiotics biotransformation in the development of recurrent and chronic bronchitis in adolescent smokers |
| topic | recurrent and chronic bronchitis adolescent-smokers gene CYP1A1 gene GSTP1 |
| url | http://journals.uran.ua/index.php/2307-0404/article/view/109834 |
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