Seroprevalence of Toxoplasma Gondii in Parkinson’s Disease Iraqi Patients
Background Several studies have addressed the prevalence of Toxoplasma gondii (T. gondii), among Parkinson’s disease (PD) patients in different countries, and the potential association between the infection and PD; the results of these studies were conflicting. The study aims to investigate the prev...
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| Format: | Article |
| Language: | English |
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College of Pharmacy University of Baghdad
2021-12-01
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| Series: | Iraqi Journal of Pharmaceutical Sciences |
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| Online Access: | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/1295 |
| _version_ | 1818948613934415872 |
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| author | Maysoon Abdul-zahra Merdaw Ali Abdulhussain Kasim Mahmood Kahtan Salih |
| author_facet | Maysoon Abdul-zahra Merdaw Ali Abdulhussain Kasim Mahmood Kahtan Salih |
| author_sort | Maysoon Abdul-zahra Merdaw |
| collection | DOAJ |
| description | Background Several studies have addressed the prevalence of Toxoplasma gondii (T. gondii), among Parkinson’s disease (PD) patients in different countries, and the potential association between the infection and PD; the results of these studies were conflicting. The study aims to investigate the prevalence of Toxoplasma infection among sample of Iraqi PD patients. Also, to examine the potential association of age, PD duration, gender, smoking habit, zone of residence and family history of PD, with the prevalence of Toxoplasma infection in PD patients.
Patients and Methods Seventy-four PD patients attaining Dr. Saad Al-Witry Neuroscience Hospital in Baghdad/ Iraq for routine follow up, from different Iraqi governorates, were enrolled in this cross-sectional study. Detection of T. gondii was performed by detection of anti-Toxoplasma IgG and IgM antibodies in serum by ELISA method.
Results The frequency rate of anti-Toxoplasma IgG antibodies in Iraqi PD patients was 43.2% (32/74); while, none of the participants was seropositive for anti-Toxoplasma IgM antibody. Age, PD duration, smoking habit and zone of residences were not shown to be risk factors for Toxoplasma infection in PD patients (P>0.05); meanwhile, female gender and positive family history of PD were shown to have a protective effect ((OR, 0.309; 95% CI, 0.099-0.966; P= 0.043) and (OR, 0.162; 95% CI, 0.037-0.705; P=0.015); respectively).
Conclusions
The prevalence rate of Toxoplasma infection in Iraqi PD patients is 43.2%, female gender and positive family history of PD might protect against Toxoplasma infection in PD patients.
Key words: Iraq, Neurodegeneration, Parkinson’s disease, Prevalence, Toxoplasma gondii |
| first_indexed | 2024-12-20T08:49:35Z |
| format | Article |
| id | doaj.art-26bf8d516934413fbb0bf6a339028708 |
| institution | Directory Open Access Journal |
| issn | 2521-3512 1683-3597 |
| language | English |
| last_indexed | 2024-12-20T08:49:35Z |
| publishDate | 2021-12-01 |
| publisher | College of Pharmacy University of Baghdad |
| record_format | Article |
| series | Iraqi Journal of Pharmaceutical Sciences |
| spelling | doaj.art-26bf8d516934413fbb0bf6a3390287082022-12-21T19:46:10ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences2521-35121683-35972021-12-0130210.31351/vol30iss2pp99=105Seroprevalence of Toxoplasma Gondii in Parkinson’s Disease Iraqi PatientsMaysoon Abdul-zahra Merdaw0Ali Abdulhussain Kasim1Mahmood Kahtan Salih2Department of Clinical Laboratory Sciences, College of Pharmacy, University of Baghdad, Baghdad-IraqCollege of Pharmacy/ University of BaghdadDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad, Baghdad-IraqBackground Several studies have addressed the prevalence of Toxoplasma gondii (T. gondii), among Parkinson’s disease (PD) patients in different countries, and the potential association between the infection and PD; the results of these studies were conflicting. The study aims to investigate the prevalence of Toxoplasma infection among sample of Iraqi PD patients. Also, to examine the potential association of age, PD duration, gender, smoking habit, zone of residence and family history of PD, with the prevalence of Toxoplasma infection in PD patients. Patients and Methods Seventy-four PD patients attaining Dr. Saad Al-Witry Neuroscience Hospital in Baghdad/ Iraq for routine follow up, from different Iraqi governorates, were enrolled in this cross-sectional study. Detection of T. gondii was performed by detection of anti-Toxoplasma IgG and IgM antibodies in serum by ELISA method. Results The frequency rate of anti-Toxoplasma IgG antibodies in Iraqi PD patients was 43.2% (32/74); while, none of the participants was seropositive for anti-Toxoplasma IgM antibody. Age, PD duration, smoking habit and zone of residences were not shown to be risk factors for Toxoplasma infection in PD patients (P>0.05); meanwhile, female gender and positive family history of PD were shown to have a protective effect ((OR, 0.309; 95% CI, 0.099-0.966; P= 0.043) and (OR, 0.162; 95% CI, 0.037-0.705; P=0.015); respectively). Conclusions The prevalence rate of Toxoplasma infection in Iraqi PD patients is 43.2%, female gender and positive family history of PD might protect against Toxoplasma infection in PD patients. Key words: Iraq, Neurodegeneration, Parkinson’s disease, Prevalence, Toxoplasma gondiihttps://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/1295Iraq, Neurodegeneration, Parkinson’s disease, Prevalence, Toxoplasma gondii |
| spellingShingle | Maysoon Abdul-zahra Merdaw Ali Abdulhussain Kasim Mahmood Kahtan Salih Seroprevalence of Toxoplasma Gondii in Parkinson’s Disease Iraqi Patients Iraqi Journal of Pharmaceutical Sciences Iraq, Neurodegeneration, Parkinson’s disease, Prevalence, Toxoplasma gondii |
| title | Seroprevalence of Toxoplasma Gondii in Parkinson’s Disease Iraqi Patients |
| title_full | Seroprevalence of Toxoplasma Gondii in Parkinson’s Disease Iraqi Patients |
| title_fullStr | Seroprevalence of Toxoplasma Gondii in Parkinson’s Disease Iraqi Patients |
| title_full_unstemmed | Seroprevalence of Toxoplasma Gondii in Parkinson’s Disease Iraqi Patients |
| title_short | Seroprevalence of Toxoplasma Gondii in Parkinson’s Disease Iraqi Patients |
| title_sort | seroprevalence of toxoplasma gondii in parkinson s disease iraqi patients |
| topic | Iraq, Neurodegeneration, Parkinson’s disease, Prevalence, Toxoplasma gondii |
| url | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/1295 |
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