Nrg1 haploinsufficiency alters inhibitory cortical circuits

Nrg1 haploinsufficiency alters inhibitory cortical circuits

Neuregulin 1 (NRG1) and its receptor ERBB4 are schizophrenia (SZ) risk genes that control the development of both excitatory and inhibitory cortical circuits. Most studies focused on the characterization ErbB4 deficient mice. However, ErbB4 deletion concurrently perturbs the signaling of Nrg1 and Ne...

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Bibliographic Details
Main Authors: Carmen Navarro-Gonzalez, Héctor Carceller, Marina Benito Vicente, Irene Serra, Marta Navarrete, Yaiza Domínguez-Canterla, Ángela Rodríguez-Prieto, Ana González-Manteiga, Pietro Fazzari
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Neurobiology of Disease
Subjects:
Nrg1
Schizophrenia
Cortical neurons
Inhibitory neurotransmission
Magnetic resonance spectroscopy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121001911

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http://www.sciencedirect.com/science/article/pii/S0969996121001911

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