Association between fibrinogen and bone mineral density in postmenopausal women
Abstract Objective There is very limited of evidence linking fibrinogen and bone mineral density (BMD) in postmenopausal women. Therefore, this study intended to examine the relationship between fibrinogen and total BMD in postmenopausal women. Methods This cross-sectional analysis included 2043 pos...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | Journal of Orthopaedic Surgery and Research |
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| Online Access: | https://doi.org/10.1186/s13018-023-03785-7 |
| _version_ | 1797817824810369024 |
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| author | Weibin Du Zhenwei Wang Yi Dong Jintao Hu Xiaoping Chen |
| author_facet | Weibin Du Zhenwei Wang Yi Dong Jintao Hu Xiaoping Chen |
| author_sort | Weibin Du |
| collection | DOAJ |
| description | Abstract Objective There is very limited of evidence linking fibrinogen and bone mineral density (BMD) in postmenopausal women. Therefore, this study intended to examine the relationship between fibrinogen and total BMD in postmenopausal women. Methods This cross-sectional analysis included 2043 postmenopausal women aged 50 years and older from the 1999 to 2002 National Health and Nutrition Examination Survey. The independent variable was fibrinogen and the outcome variable was total BMD. The association between fibrinogen and total BMD in postmenopausal women was examined using multivariate linear regression models, with subgroup analyses stratified by race. Smoothing curve fitting and generalized additive models further analyzed the sample data. Results In multiple regression models adjusted for potential confounders, fibrinogen was negatively associated with total BMD (model 1: − 0.0002 [− 0.0002, − 0.0001], model 2: − 0.0000 [− 0.0001, − 0.0000], model 3: − 0.0001 [− 0.0001, − 0.0001]). In subgroup analysis stratified by race, fibrinogen levels were negatively associated with total BMD in postmenopausal women, Non-Hispanic Whites, and Mexican Americans. However, in Non-Hispanic Blacks, the correlation between fibrinogen levels and total BMD was not significant. For individuals that identify as Other Races, fibrinogen levels were positively correlated with total BMD. Conclusion Our findings show a negative association between fibrinogen levels and total BMD in most postmenopausal women aged 50 years and older, however, is variable by race. In postmenopausal women, Non-Hispanic Whites and Mexican Americans, relatively high fibrinogen levels may be adverse to bone health. |
| first_indexed | 2024-03-13T08:59:08Z |
| format | Article |
| id | doaj.art-26c2924e7fa1409e91e94333ec30b7cb |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-03-13T08:59:08Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-26c2924e7fa1409e91e94333ec30b7cb2023-05-28T11:22:59ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2023-05-011811610.1186/s13018-023-03785-7Association between fibrinogen and bone mineral density in postmenopausal womenWeibin Du0Zhenwei Wang1Yi Dong2Jintao Hu3Xiaoping Chen4Research Institute of Orthopedics, The Affiliated Jiangnan Hospital of Zhejiang Chinese Medical UniversityResearch Institute of Orthopedics, The Affiliated Jiangnan Hospital of Zhejiang Chinese Medical UniversityShaoxing TCM Hospital Affiliated to Zhejiang Chinese Medical UniversityOrthopedics and Traumatology Department, Hangzhou TCM Hospital, Affilliated to Zhejiang Chinese Medical UniversityResearch Institute of Orthopedics, The Affiliated Jiangnan Hospital of Zhejiang Chinese Medical UniversityAbstract Objective There is very limited of evidence linking fibrinogen and bone mineral density (BMD) in postmenopausal women. Therefore, this study intended to examine the relationship between fibrinogen and total BMD in postmenopausal women. Methods This cross-sectional analysis included 2043 postmenopausal women aged 50 years and older from the 1999 to 2002 National Health and Nutrition Examination Survey. The independent variable was fibrinogen and the outcome variable was total BMD. The association between fibrinogen and total BMD in postmenopausal women was examined using multivariate linear regression models, with subgroup analyses stratified by race. Smoothing curve fitting and generalized additive models further analyzed the sample data. Results In multiple regression models adjusted for potential confounders, fibrinogen was negatively associated with total BMD (model 1: − 0.0002 [− 0.0002, − 0.0001], model 2: − 0.0000 [− 0.0001, − 0.0000], model 3: − 0.0001 [− 0.0001, − 0.0001]). In subgroup analysis stratified by race, fibrinogen levels were negatively associated with total BMD in postmenopausal women, Non-Hispanic Whites, and Mexican Americans. However, in Non-Hispanic Blacks, the correlation between fibrinogen levels and total BMD was not significant. For individuals that identify as Other Races, fibrinogen levels were positively correlated with total BMD. Conclusion Our findings show a negative association between fibrinogen levels and total BMD in most postmenopausal women aged 50 years and older, however, is variable by race. In postmenopausal women, Non-Hispanic Whites and Mexican Americans, relatively high fibrinogen levels may be adverse to bone health.https://doi.org/10.1186/s13018-023-03785-7FibrinogenBone mineral densityPostmenopausal womenOsteoporosisNHANES |
| spellingShingle | Weibin Du Zhenwei Wang Yi Dong Jintao Hu Xiaoping Chen Association between fibrinogen and bone mineral density in postmenopausal women Journal of Orthopaedic Surgery and Research Fibrinogen Bone mineral density Postmenopausal women Osteoporosis NHANES |
| title | Association between fibrinogen and bone mineral density in postmenopausal women |
| title_full | Association between fibrinogen and bone mineral density in postmenopausal women |
| title_fullStr | Association between fibrinogen and bone mineral density in postmenopausal women |
| title_full_unstemmed | Association between fibrinogen and bone mineral density in postmenopausal women |
| title_short | Association between fibrinogen and bone mineral density in postmenopausal women |
| title_sort | association between fibrinogen and bone mineral density in postmenopausal women |
| topic | Fibrinogen Bone mineral density Postmenopausal women Osteoporosis NHANES |
| url | https://doi.org/10.1186/s13018-023-03785-7 |
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