Human collectin-11 (COLEC11) and its synergic genetic interaction with MASP2 are associated with the pathophysiology of Chagas Disease.

Human collectin-11 (COLEC11) and its synergic genetic interaction with MASP2 are associated with the pathophysiology of Chagas Disease.

Chagas Disease (CD) is an anthropozoonosis caused by Trypanosoma cruzi. With complex pathophysiology and variable clinical presentation, CD outcome can be influenced by parasite persistence and the host immune response. Complement activation is one of the primary defense mechanisms against pathogens...

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Bibliographic Details
Main Authors: Thaisa Lucas Sandri, Fabiana Antunes Andrade, Kárita Cláudia Freitas Lidani, Elias Einig, Angelica Beate Winter Boldt, Benjamin Mordmüller, Meral Esen, Iara J Messias-Reason
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-04-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0007324

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