Immediate hypersensitivity reaction to carboxymethylcellulose in lidocaine jelly and dimethicone drops: A case report and mini‐review
Abstract Excipient allergies are rare and difficult to diagnose. Carboxymethylcellulose (CMC, carmellose sodium) is an anionic water‐soluble polymer derived from native cellulose, that is, used as an excipient. Here, we report a case of urticaria caused by the CMC in lidocaine jelly and dimethicone...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
|
| Series: | Journal of Cutaneous Immunology and Allergy |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cia2.12261 |
| _version_ | 1797334387060113408 |
|---|---|
| author | Eri Hotta Risa Tamagawa‐Mineoka Yuri Onishi Ayaka Sotozono Megumi Kusunoki Junko Hattori Natsue Ioka Hiromi Mizutani Koji Masuda Norito Katoh |
| author_facet | Eri Hotta Risa Tamagawa‐Mineoka Yuri Onishi Ayaka Sotozono Megumi Kusunoki Junko Hattori Natsue Ioka Hiromi Mizutani Koji Masuda Norito Katoh |
| author_sort | Eri Hotta |
| collection | DOAJ |
| description | Abstract Excipient allergies are rare and difficult to diagnose. Carboxymethylcellulose (CMC, carmellose sodium) is an anionic water‐soluble polymer derived from native cellulose, that is, used as an excipient. Here, we report a case of urticaria caused by the CMC in lidocaine jelly and dimethicone drops, which had used for upper gastrointestinal endoscopy. CMC is widely used in pharmaceutical preparations, food additives, and other pharmaceuticals, and its use is increasing. However, there are few reports on immediate hypersensitivity reactions because substances containing CMC. Previous reports and our case suggest that excipients, such as CMC, can be potential hidden allergens. |
| first_indexed | 2024-03-08T08:19:06Z |
| format | Article |
| id | doaj.art-26c4eb0917ec475d9d92917f340f234d |
| institution | Directory Open Access Journal |
| issn | 2574-4593 |
| language | English |
| last_indexed | 2024-03-08T08:19:06Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Journal of Cutaneous Immunology and Allergy |
| spelling | doaj.art-26c4eb0917ec475d9d92917f340f234d2024-02-02T06:24:43ZengFrontiers Media S.A.Journal of Cutaneous Immunology and Allergy2574-45932022-12-015621722110.1002/cia2.12261Immediate hypersensitivity reaction to carboxymethylcellulose in lidocaine jelly and dimethicone drops: A case report and mini‐reviewEri Hotta0Risa Tamagawa‐Mineoka1Yuri Onishi2Ayaka Sotozono3Megumi Kusunoki4Junko Hattori5Natsue Ioka6Hiromi Mizutani7Koji Masuda8Norito Katoh9Department of Dermatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto JapanDepartment of Dermatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto JapanDepartment of Dermatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto JapanDepartment of Dermatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto JapanDepartment of Dermatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto JapanDepartment of Dermatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto JapanDepartment of Dermatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto JapanDepartment of Dermatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto JapanDepartment of Dermatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto JapanDepartment of Dermatology, Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto JapanAbstract Excipient allergies are rare and difficult to diagnose. Carboxymethylcellulose (CMC, carmellose sodium) is an anionic water‐soluble polymer derived from native cellulose, that is, used as an excipient. Here, we report a case of urticaria caused by the CMC in lidocaine jelly and dimethicone drops, which had used for upper gastrointestinal endoscopy. CMC is widely used in pharmaceutical preparations, food additives, and other pharmaceuticals, and its use is increasing. However, there are few reports on immediate hypersensitivity reactions because substances containing CMC. Previous reports and our case suggest that excipients, such as CMC, can be potential hidden allergens.https://doi.org/10.1002/cia2.12261carboxymethylcellulosedimethicone dropsimmediate hypersensitivity reactionlate‐onset reactionlidocaine jellyoral intake |
| spellingShingle | Eri Hotta Risa Tamagawa‐Mineoka Yuri Onishi Ayaka Sotozono Megumi Kusunoki Junko Hattori Natsue Ioka Hiromi Mizutani Koji Masuda Norito Katoh Immediate hypersensitivity reaction to carboxymethylcellulose in lidocaine jelly and dimethicone drops: A case report and mini‐review Journal of Cutaneous Immunology and Allergy carboxymethylcellulose dimethicone drops immediate hypersensitivity reaction late‐onset reaction lidocaine jelly oral intake |
| title | Immediate hypersensitivity reaction to carboxymethylcellulose in lidocaine jelly and dimethicone drops: A case report and mini‐review |
| title_full | Immediate hypersensitivity reaction to carboxymethylcellulose in lidocaine jelly and dimethicone drops: A case report and mini‐review |
| title_fullStr | Immediate hypersensitivity reaction to carboxymethylcellulose in lidocaine jelly and dimethicone drops: A case report and mini‐review |
| title_full_unstemmed | Immediate hypersensitivity reaction to carboxymethylcellulose in lidocaine jelly and dimethicone drops: A case report and mini‐review |
| title_short | Immediate hypersensitivity reaction to carboxymethylcellulose in lidocaine jelly and dimethicone drops: A case report and mini‐review |
| title_sort | immediate hypersensitivity reaction to carboxymethylcellulose in lidocaine jelly and dimethicone drops a case report and mini review |
| topic | carboxymethylcellulose dimethicone drops immediate hypersensitivity reaction late‐onset reaction lidocaine jelly oral intake |
| url | https://doi.org/10.1002/cia2.12261 |
| work_keys_str_mv | AT erihotta immediatehypersensitivityreactiontocarboxymethylcelluloseinlidocainejellyanddimethiconedropsacasereportandminireview AT risatamagawamineoka immediatehypersensitivityreactiontocarboxymethylcelluloseinlidocainejellyanddimethiconedropsacasereportandminireview AT yurionishi immediatehypersensitivityreactiontocarboxymethylcelluloseinlidocainejellyanddimethiconedropsacasereportandminireview AT ayakasotozono immediatehypersensitivityreactiontocarboxymethylcelluloseinlidocainejellyanddimethiconedropsacasereportandminireview AT megumikusunoki immediatehypersensitivityreactiontocarboxymethylcelluloseinlidocainejellyanddimethiconedropsacasereportandminireview AT junkohattori immediatehypersensitivityreactiontocarboxymethylcelluloseinlidocainejellyanddimethiconedropsacasereportandminireview AT natsueioka immediatehypersensitivityreactiontocarboxymethylcelluloseinlidocainejellyanddimethiconedropsacasereportandminireview AT hiromimizutani immediatehypersensitivityreactiontocarboxymethylcelluloseinlidocainejellyanddimethiconedropsacasereportandminireview AT kojimasuda immediatehypersensitivityreactiontocarboxymethylcelluloseinlidocainejellyanddimethiconedropsacasereportandminireview AT noritokatoh immediatehypersensitivityreactiontocarboxymethylcelluloseinlidocainejellyanddimethiconedropsacasereportandminireview |