Metal- and solvent-free preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by deep eutectic solvents
A straightforward method for the preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by an acidic deep eutectic solvent from choline chloride (ChCl) and phenol via the Biginelli reaction of 2-aminobenzimidazole, ethyl acetoacetate, and aldehydes has been developed under metal- a...
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| Format: | Article |
| Language: | English |
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Vietnam Ministry of Science and Technology
2022-03-01
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| Series: | Vietnam Journal of Science, Technology and Engineering |
| Subjects: | |
| Online Access: | https://vietnamscience.vjst.vn/index.php/vjste/article/view/60 |
| _version_ | 1797937738332241920 |
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| author | Thuy-Duy Thi Nguyen Anh Vy Truong Hoang Phuong Tran |
| author_facet | Thuy-Duy Thi Nguyen Anh Vy Truong Hoang Phuong Tran |
| author_sort | Thuy-Duy Thi Nguyen |
| collection | DOAJ |
| description |
A straightforward method for the preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by an acidic deep eutectic solvent from choline chloride (ChCl) and phenol via the Biginelli reaction of 2-aminobenzimidazole, ethyl acetoacetate, and aldehydes has been developed under metal- and solvent-free conditions. The desired products were obtained in moderate to good yield (49-79%) and the DESs were known as an economical and environmentally friendly catalyst.
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| first_indexed | 2024-04-10T18:48:59Z |
| format | Article |
| id | doaj.art-26c90eb41f17441982c34131e12c8ebe |
| institution | Directory Open Access Journal |
| issn | 2525-2461 2615-9937 |
| language | English |
| last_indexed | 2024-04-10T18:48:59Z |
| publishDate | 2022-03-01 |
| publisher | Vietnam Ministry of Science and Technology |
| record_format | Article |
| series | Vietnam Journal of Science, Technology and Engineering |
| spelling | doaj.art-26c90eb41f17441982c34131e12c8ebe2023-02-01T08:17:07ZengVietnam Ministry of Science and TechnologyVietnam Journal of Science, Technology and Engineering2525-24612615-99372022-03-0163310.31276/VJSTE.63(3).15-17Metal- and solvent-free preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by deep eutectic solventsThuy-Duy Thi Nguyen0Anh Vy Truong1Hoang Phuong Tran2Department of Organic Chemistry, Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh cityDEDepartment of Organic Chemistry, Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh cityDepartment of Organic Chemistry, Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh city A straightforward method for the preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by an acidic deep eutectic solvent from choline chloride (ChCl) and phenol via the Biginelli reaction of 2-aminobenzimidazole, ethyl acetoacetate, and aldehydes has been developed under metal- and solvent-free conditions. The desired products were obtained in moderate to good yield (49-79%) and the DESs were known as an economical and environmentally friendly catalyst. https://vietnamscience.vjst.vn/index.php/vjste/article/view/60Biginelli reactiondeep eutectic solventsgreen catalystgreen chemistry |
| spellingShingle | Thuy-Duy Thi Nguyen Anh Vy Truong Hoang Phuong Tran Metal- and solvent-free preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by deep eutectic solvents Vietnam Journal of Science, Technology and Engineering Biginelli reaction deep eutectic solvents green catalyst green chemistry |
| title | Metal- and solvent-free preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by deep eutectic solvents |
| title_full | Metal- and solvent-free preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by deep eutectic solvents |
| title_fullStr | Metal- and solvent-free preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by deep eutectic solvents |
| title_full_unstemmed | Metal- and solvent-free preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by deep eutectic solvents |
| title_short | Metal- and solvent-free preparation of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives catalysed by deep eutectic solvents |
| title_sort | metal and solvent free preparation of benzo 4 5 imidazo 1 2 a pyrimidine derivatives catalysed by deep eutectic solvents |
| topic | Biginelli reaction deep eutectic solvents green catalyst green chemistry |
| url | https://vietnamscience.vjst.vn/index.php/vjste/article/view/60 |
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