Increasing prevalence of familial recurrence of multiple sclerosis in Iran: a population based study of Tehran registry 1999–2015
Abstract Background Tehran is the capital of Iran with an increasing multiple sclerosis (MS) prevalence. A retrospective population-based study was conducted to evaluate the trends of MS prevalence in Tehran. Methods A population-based survey was conducted for the period 1999 to 2015, based on Irani...
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| Format: | Article |
| Language: | English |
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BMC
2018-02-01
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| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12883-018-1019-2 |
| _version_ | 1818195770935869440 |
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| author | Sharareh Eskandarieh Narges Sistany Allahabadi Malihe Sadeghi Mohammad Ali Sahraian |
| author_facet | Sharareh Eskandarieh Narges Sistany Allahabadi Malihe Sadeghi Mohammad Ali Sahraian |
| author_sort | Sharareh Eskandarieh |
| collection | DOAJ |
| description | Abstract Background Tehran is the capital of Iran with an increasing multiple sclerosis (MS) prevalence. A retrospective population-based study was conducted to evaluate the trends of MS prevalence in Tehran. Methods A population-based survey was conducted for the period 1999 to 2015, based on Iranian MS Society (IMSS) registry system of Tehran, the capital city of Iran. Point regression analysis was applied on MS trend data to find annual percent change (APC). The logistic regression analysis was used to estimate the odds ratio (OR) for individual variables in order to assess factors associating with familial recurrence of MS. P values < 0.05 were considered significant. Results MS prevalence has significantly increased during the study period from 1999 to 2015 (56.22 per 100,000). Total point prevalence of MS was 115.94 per 100,000 persons in 2015 compared to general population. Positive family history of MS was observed among 12.4% of patients. The strongest association amongst first-degree relatives was found in siblings, p value ≤ 0.001. Conclusion MS prevalence is rising in Tehran and this city is one of the regions with highest MS prevalence in Asia. In this sample, the largest proportion of relatives with MS were found among first-degree relatives, particularly siblings. Familial recurrence correlated with relative type. |
| first_indexed | 2024-12-12T01:23:28Z |
| format | Article |
| id | doaj.art-26c9a763764240c685cb65ea181c28bd |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-12T01:23:28Z |
| publishDate | 2018-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-26c9a763764240c685cb65ea181c28bd2022-12-22T00:43:10ZengBMCBMC Neurology1471-23772018-02-011811610.1186/s12883-018-1019-2Increasing prevalence of familial recurrence of multiple sclerosis in Iran: a population based study of Tehran registry 1999–2015Sharareh Eskandarieh0Narges Sistany Allahabadi1Malihe Sadeghi2Mohammad Ali Sahraian3Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical SciencesMS Research Center, Neuroscience Institute, Tehran University of Medical SciencesMS Research Center, Neuroscience Institute, Tehran University of Medical SciencesMS Research Center, Neuroscience Institute, Tehran University of Medical SciencesAbstract Background Tehran is the capital of Iran with an increasing multiple sclerosis (MS) prevalence. A retrospective population-based study was conducted to evaluate the trends of MS prevalence in Tehran. Methods A population-based survey was conducted for the period 1999 to 2015, based on Iranian MS Society (IMSS) registry system of Tehran, the capital city of Iran. Point regression analysis was applied on MS trend data to find annual percent change (APC). The logistic regression analysis was used to estimate the odds ratio (OR) for individual variables in order to assess factors associating with familial recurrence of MS. P values < 0.05 were considered significant. Results MS prevalence has significantly increased during the study period from 1999 to 2015 (56.22 per 100,000). Total point prevalence of MS was 115.94 per 100,000 persons in 2015 compared to general population. Positive family history of MS was observed among 12.4% of patients. The strongest association amongst first-degree relatives was found in siblings, p value ≤ 0.001. Conclusion MS prevalence is rising in Tehran and this city is one of the regions with highest MS prevalence in Asia. In this sample, the largest proportion of relatives with MS were found among first-degree relatives, particularly siblings. Familial recurrence correlated with relative type.http://link.springer.com/article/10.1186/s12883-018-1019-2Multiple sclerosisPrevalenceFamilial recurrenceTehran |
| spellingShingle | Sharareh Eskandarieh Narges Sistany Allahabadi Malihe Sadeghi Mohammad Ali Sahraian Increasing prevalence of familial recurrence of multiple sclerosis in Iran: a population based study of Tehran registry 1999–2015 BMC Neurology Multiple sclerosis Prevalence Familial recurrence Tehran |
| title | Increasing prevalence of familial recurrence of multiple sclerosis in Iran: a population based study of Tehran registry 1999–2015 |
| title_full | Increasing prevalence of familial recurrence of multiple sclerosis in Iran: a population based study of Tehran registry 1999–2015 |
| title_fullStr | Increasing prevalence of familial recurrence of multiple sclerosis in Iran: a population based study of Tehran registry 1999–2015 |
| title_full_unstemmed | Increasing prevalence of familial recurrence of multiple sclerosis in Iran: a population based study of Tehran registry 1999–2015 |
| title_short | Increasing prevalence of familial recurrence of multiple sclerosis in Iran: a population based study of Tehran registry 1999–2015 |
| title_sort | increasing prevalence of familial recurrence of multiple sclerosis in iran a population based study of tehran registry 1999 2015 |
| topic | Multiple sclerosis Prevalence Familial recurrence Tehran |
| url | http://link.springer.com/article/10.1186/s12883-018-1019-2 |
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