Long‐Term Association of Venous Thromboembolism With Frailty, Physical Functioning, and Quality of Life: The Atherosclerosis Risk in Communities Study
Background Relatively little is known about the long‐term consequences of venous thromboembolism (VTE) on physical functioning. We compared long‐term frailty status, physical function, and quality of life among survivors of VTE with survivors of coronary heart disease (CHD) and stroke, and with thos...
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| Format: | Article |
| Language: | English |
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Wiley
2020-06-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.119.015656 |
| _version_ | 1818315263642173440 |
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| author | Pamela L. Lutsey B. Gwen Windham Jeffrey R. Misialek Mary Cushman Anna Kucharska‐Newton Saonli Basu Aaron R. Folsom |
| author_facet | Pamela L. Lutsey B. Gwen Windham Jeffrey R. Misialek Mary Cushman Anna Kucharska‐Newton Saonli Basu Aaron R. Folsom |
| author_sort | Pamela L. Lutsey |
| collection | DOAJ |
| description | Background Relatively little is known about the long‐term consequences of venous thromboembolism (VTE) on physical functioning. We compared long‐term frailty status, physical function, and quality of life among survivors of VTE with survivors of coronary heart disease (CHD) and stroke, and with those without these diseases. Methods and Results Cases of VTE, CHD, and stroke were continuously identified since ARIC (Atherosclerosis Risk in Communities Study) recruitment during 1987 to 1989. Functional measures were objectively captured at ARIC clinic visits 5 (2011–2013) and 6 (2016–2017); quality of life was self‐reported. The 6161 participants at visit 5 were, on average, 75.7 (range, 66–90) years of age. By visit 5, 3.2% had had a VTE, 6.9% CHD, and 3.4% stroke. Compared with those without any of these conditions, VTE survivors were more likely to be frail (odds ratio [OR], 3.11; 95% CI, 1.80–5.36) and have low (<10) versus good scores on the Short Physical Performance Battery (OR, 3.59; 95% CI, 2.36–5.47). They also had slower gait speed, less endurance, and lower physical quality of life. VTE survivors were similar to coronary heart disease and stroke survivors on categorical frailty and outcomes on Short Physical Performance Battery assessment. When score on the Short Physical Performance Battery instrument was modeled continuously, VTE survivors performed better than stroke survivors but worse than CHD survivors. Conclusions VTE survivors had triple the odds of frailty and poorer physical function than those without the vascular diseases considered. Their function was somewhat worse than that of CHD survivors, but better than stroke survivors. These findings suggest that VTE patients may benefit from additional efforts to improve postevent physical functioning. |
| first_indexed | 2024-12-13T09:02:46Z |
| format | Article |
| id | doaj.art-26ca82e650d745aa88876c85fe89f63b |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-13T09:02:46Z |
| publishDate | 2020-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-26ca82e650d745aa88876c85fe89f63b2022-12-21T23:53:07ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802020-06-0191210.1161/JAHA.119.015656Long‐Term Association of Venous Thromboembolism With Frailty, Physical Functioning, and Quality of Life: The Atherosclerosis Risk in Communities StudyPamela L. Lutsey0B. Gwen Windham1Jeffrey R. Misialek2Mary Cushman3Anna Kucharska‐Newton4Saonli Basu5Aaron R. Folsom6Division of Epidemiology and Community Health School of Public Health University of Minnesota Minneapolis MNDivision of Geriatrics Department of Medicine University of Mississippi Medical Center Jackson MSDivision of Epidemiology and Community Health School of Public Health University of Minnesota Minneapolis MNDivision of Hematology and Oncology Department of Medicine University of Vermont Colchester VTDivision of Epidemiology College of Public Health University of Kentucky Lexington KYDivision of Biostatistics School of Public Health University of Minnesota Minneapolis MNDivision of Epidemiology and Community Health School of Public Health University of Minnesota Minneapolis MNBackground Relatively little is known about the long‐term consequences of venous thromboembolism (VTE) on physical functioning. We compared long‐term frailty status, physical function, and quality of life among survivors of VTE with survivors of coronary heart disease (CHD) and stroke, and with those without these diseases. Methods and Results Cases of VTE, CHD, and stroke were continuously identified since ARIC (Atherosclerosis Risk in Communities Study) recruitment during 1987 to 1989. Functional measures were objectively captured at ARIC clinic visits 5 (2011–2013) and 6 (2016–2017); quality of life was self‐reported. The 6161 participants at visit 5 were, on average, 75.7 (range, 66–90) years of age. By visit 5, 3.2% had had a VTE, 6.9% CHD, and 3.4% stroke. Compared with those without any of these conditions, VTE survivors were more likely to be frail (odds ratio [OR], 3.11; 95% CI, 1.80–5.36) and have low (<10) versus good scores on the Short Physical Performance Battery (OR, 3.59; 95% CI, 2.36–5.47). They also had slower gait speed, less endurance, and lower physical quality of life. VTE survivors were similar to coronary heart disease and stroke survivors on categorical frailty and outcomes on Short Physical Performance Battery assessment. When score on the Short Physical Performance Battery instrument was modeled continuously, VTE survivors performed better than stroke survivors but worse than CHD survivors. Conclusions VTE survivors had triple the odds of frailty and poorer physical function than those without the vascular diseases considered. Their function was somewhat worse than that of CHD survivors, but better than stroke survivors. These findings suggest that VTE patients may benefit from additional efforts to improve postevent physical functioning.https://www.ahajournals.org/doi/10.1161/JAHA.119.015656frailtyphysical functionquality of lifevenous thromboembolism |
| spellingShingle | Pamela L. Lutsey B. Gwen Windham Jeffrey R. Misialek Mary Cushman Anna Kucharska‐Newton Saonli Basu Aaron R. Folsom Long‐Term Association of Venous Thromboembolism With Frailty, Physical Functioning, and Quality of Life: The Atherosclerosis Risk in Communities Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease frailty physical function quality of life venous thromboembolism |
| title | Long‐Term Association of Venous Thromboembolism With Frailty, Physical Functioning, and Quality of Life: The Atherosclerosis Risk in Communities Study |
| title_full | Long‐Term Association of Venous Thromboembolism With Frailty, Physical Functioning, and Quality of Life: The Atherosclerosis Risk in Communities Study |
| title_fullStr | Long‐Term Association of Venous Thromboembolism With Frailty, Physical Functioning, and Quality of Life: The Atherosclerosis Risk in Communities Study |
| title_full_unstemmed | Long‐Term Association of Venous Thromboembolism With Frailty, Physical Functioning, and Quality of Life: The Atherosclerosis Risk in Communities Study |
| title_short | Long‐Term Association of Venous Thromboembolism With Frailty, Physical Functioning, and Quality of Life: The Atherosclerosis Risk in Communities Study |
| title_sort | long term association of venous thromboembolism with frailty physical functioning and quality of life the atherosclerosis risk in communities study |
| topic | frailty physical function quality of life venous thromboembolism |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.119.015656 |
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