Persistence of hippocampal and striatal multivoxel patterns during awake rest after motor sequence learning
Summary: Memory consolidation, the process by which newly encoded and fragile memories become more robust, is thought to be supported by the reactivation of brain regions - including the hippocampus - during post-learning rest. While hippocampal reactivations have been demonstrated in humans in the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222017709 |
| _version_ | 1811226059238014976 |
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| author | Bradley R. King Mareike A. Gann Dante Mantini Julien Doyon Geneviève Albouy |
| author_facet | Bradley R. King Mareike A. Gann Dante Mantini Julien Doyon Geneviève Albouy |
| author_sort | Bradley R. King |
| collection | DOAJ |
| description | Summary: Memory consolidation, the process by which newly encoded and fragile memories become more robust, is thought to be supported by the reactivation of brain regions - including the hippocampus - during post-learning rest. While hippocampal reactivations have been demonstrated in humans in the declarative memory domain, it remains unknown whether such a process takes place after motor learning. Using multivariate analyses of task-related and resting state fMRI data, here we show that patterns of brain activity within both the hippocampus and striatum elicited during motor learning persist into post-learning rest, indicative of the reactivation of learning-related neural activity patterns. Moreover, results indicate that hippocampal reactivation reflects the spatial representation of the learned motor sequence. These results thus provide insights into the functional significance of neural reactivation after motor sequence learning. |
| first_indexed | 2024-04-12T09:19:04Z |
| format | Article |
| id | doaj.art-26ce36d1f6294900a1167444ddd89117 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-12T09:19:04Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-26ce36d1f6294900a1167444ddd891172022-12-22T03:38:44ZengElsevieriScience2589-00422022-12-012512105498Persistence of hippocampal and striatal multivoxel patterns during awake rest after motor sequence learningBradley R. King0Mareike A. Gann1Dante Mantini2Julien Doyon3Geneviève Albouy4Department of Health and Kinesiology, College of Health, University of Utah, Salt Lake City, UT 84112, USADepartment of Movement Sciences, Movement Control and Neuroplasticity Research Group, KU Leuven, 3001 Leuven, BelgiumDepartment of Movement Sciences, Movement Control and Neuroplasticity Research Group, KU Leuven, 3001 Leuven, BelgiumMcConnell Brain Imaging Centre, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2T5, CanadaDepartment of Health and Kinesiology, College of Health, University of Utah, Salt Lake City, UT 84112, USA; Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, KU Leuven, 3001 Leuven, Belgium; Corresponding authorSummary: Memory consolidation, the process by which newly encoded and fragile memories become more robust, is thought to be supported by the reactivation of brain regions - including the hippocampus - during post-learning rest. While hippocampal reactivations have been demonstrated in humans in the declarative memory domain, it remains unknown whether such a process takes place after motor learning. Using multivariate analyses of task-related and resting state fMRI data, here we show that patterns of brain activity within both the hippocampus and striatum elicited during motor learning persist into post-learning rest, indicative of the reactivation of learning-related neural activity patterns. Moreover, results indicate that hippocampal reactivation reflects the spatial representation of the learned motor sequence. These results thus provide insights into the functional significance of neural reactivation after motor sequence learning.http://www.sciencedirect.com/science/article/pii/S2589004222017709Biological sciencesNeuroscienceCognitive neuroscience |
| spellingShingle | Bradley R. King Mareike A. Gann Dante Mantini Julien Doyon Geneviève Albouy Persistence of hippocampal and striatal multivoxel patterns during awake rest after motor sequence learning iScience Biological sciences Neuroscience Cognitive neuroscience |
| title | Persistence of hippocampal and striatal multivoxel patterns during awake rest after motor sequence learning |
| title_full | Persistence of hippocampal and striatal multivoxel patterns during awake rest after motor sequence learning |
| title_fullStr | Persistence of hippocampal and striatal multivoxel patterns during awake rest after motor sequence learning |
| title_full_unstemmed | Persistence of hippocampal and striatal multivoxel patterns during awake rest after motor sequence learning |
| title_short | Persistence of hippocampal and striatal multivoxel patterns during awake rest after motor sequence learning |
| title_sort | persistence of hippocampal and striatal multivoxel patterns during awake rest after motor sequence learning |
| topic | Biological sciences Neuroscience Cognitive neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222017709 |
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