The emerging immunological role of post-translational modifications by reactive nitrogen species in cancer microenvironment
Under many inflammatory contexts, such as tumor progression, systemic and peripheral immune response is tailored by reactive nitrogen species (RNS)-dependent post-translational modifications, suggesting a biological function for these chemical alterations. RNS modify both soluble factors and recepto...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00069/full |
| _version_ | 1818913112575705088 |
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| author | Francesco eDe Sanctis Sara eSandri Giovanna eFerrarini Irene ePagliarello Silvia eSartoris Stefano eUgel Ilaria eMarigo Barbara eMolon Vincenzo eBronte |
| author_facet | Francesco eDe Sanctis Sara eSandri Giovanna eFerrarini Irene ePagliarello Silvia eSartoris Stefano eUgel Ilaria eMarigo Barbara eMolon Vincenzo eBronte |
| author_sort | Francesco eDe Sanctis |
| collection | DOAJ |
| description | Under many inflammatory contexts, such as tumor progression, systemic and peripheral immune response is tailored by reactive nitrogen species (RNS)-dependent post-translational modifications, suggesting a biological function for these chemical alterations. RNS modify both soluble factors and receptors essential to induce and maintain a tumor-specific immune response, creating a chemical barrier that impairs effector T cell infiltration and functionality in tumor microenvironment and supports the escape phase of cancer. RNS generation during tumor growth mainly depends on nitric oxide production by both tumor cells and tumor-infiltrating myeloid cells that constitutively activate essential metabolic pathways of L-arginine catabolism. This review provides an overview of the potential immunological and biological role of RNS-induced modifications and addresses new approaches targeting RNS either in search of novel biomarkers or to improve anti-cancer treatment. |
| first_indexed | 2024-12-19T23:25:19Z |
| format | Article |
| id | doaj.art-26ce7e4574bd445cb5075c666c1f1b08 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-19T23:25:19Z |
| publishDate | 2014-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-26ce7e4574bd445cb5075c666c1f1b082022-12-21T20:01:52ZengFrontiers Media S.A.Frontiers in Immunology1664-32242014-02-01510.3389/fimmu.2014.0006978399The emerging immunological role of post-translational modifications by reactive nitrogen species in cancer microenvironmentFrancesco eDe Sanctis0Sara eSandri1Giovanna eFerrarini2Irene ePagliarello3Silvia eSartoris4Stefano eUgel5Ilaria eMarigo6Barbara eMolon7Vincenzo eBronte8University of VeronaUniversity of VeronaUniversity of VeronaUniversity of VeronaUniversity of VeronaUniversity of VeronaIOV Istituto Oncologico VenetoVIMM Venetian Institute of Molecular MedicineUniversity of VeronaUnder many inflammatory contexts, such as tumor progression, systemic and peripheral immune response is tailored by reactive nitrogen species (RNS)-dependent post-translational modifications, suggesting a biological function for these chemical alterations. RNS modify both soluble factors and receptors essential to induce and maintain a tumor-specific immune response, creating a chemical barrier that impairs effector T cell infiltration and functionality in tumor microenvironment and supports the escape phase of cancer. RNS generation during tumor growth mainly depends on nitric oxide production by both tumor cells and tumor-infiltrating myeloid cells that constitutively activate essential metabolic pathways of L-arginine catabolism. This review provides an overview of the potential immunological and biological role of RNS-induced modifications and addresses new approaches targeting RNS either in search of novel biomarkers or to improve anti-cancer treatment.http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00069/fullCancermicroenvironmentimmune escapeRNSnitrotyrosine |
| spellingShingle | Francesco eDe Sanctis Sara eSandri Giovanna eFerrarini Irene ePagliarello Silvia eSartoris Stefano eUgel Ilaria eMarigo Barbara eMolon Vincenzo eBronte The emerging immunological role of post-translational modifications by reactive nitrogen species in cancer microenvironment Frontiers in Immunology Cancer microenvironment immune escape RNS nitrotyrosine |
| title | The emerging immunological role of post-translational modifications by reactive nitrogen species in cancer microenvironment |
| title_full | The emerging immunological role of post-translational modifications by reactive nitrogen species in cancer microenvironment |
| title_fullStr | The emerging immunological role of post-translational modifications by reactive nitrogen species in cancer microenvironment |
| title_full_unstemmed | The emerging immunological role of post-translational modifications by reactive nitrogen species in cancer microenvironment |
| title_short | The emerging immunological role of post-translational modifications by reactive nitrogen species in cancer microenvironment |
| title_sort | emerging immunological role of post translational modifications by reactive nitrogen species in cancer microenvironment |
| topic | Cancer microenvironment immune escape RNS nitrotyrosine |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00069/full |
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