IL-1 Beta—A Biomarker for Ischemic Stroke Prognosis and Atherosclerotic Lesions of the Internal Carotid Artery
<i>Background and Objectives:</i> Stroke is a leading cause of mortality and morbidity worldwide. Treatment of this pathology is still under development and its risk factors remain to be determined. Therefore, we aim to determine the role of interleukin-1 beta in atherosclerotic lesions...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/10/1790 |
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| author | Maria-Gabriela Catană Ioan-Adrian Popențiu Mădălina Văleanu Corina Roman-Filip Romeo-Gabriel Mihăilă |
| author_facet | Maria-Gabriela Catană Ioan-Adrian Popențiu Mădălina Văleanu Corina Roman-Filip Romeo-Gabriel Mihăilă |
| author_sort | Maria-Gabriela Catană |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> Stroke is a leading cause of mortality and morbidity worldwide. Treatment of this pathology is still under development and its risk factors remain to be determined. Therefore, we aim to determine the role of interleukin-1 beta in atherosclerotic lesions of the internal carotid artery as a risk factor for stroke and the role of this biomarker in stroke prognosis. <i>Materials and Methods</i>: This study enrolled 56 patients diagnosed with ischemic stroke in the anterior vascular territory (AVT) and posterior vascular territory (PVT). All the patients had venous blood collected at admission and 7 days after the onset of the cerebral ischemia in order to determine the plasma concentration of interleukin-1 beta. At the same time, an extracranial carotid ultrasound was performed. <i>Results</i>: The interleukin-1 beta collected at admission was positively correlated with the NIHSS at admission (Pearson index 0.424), and both measurements were correlated with carotid stenosis (Spearmen correlation index of 0.529 and 0.653, respectively). <i>Conclusions</i>: Interleukin-1 beta could be a reliable biomarker for stroke prognosis and the development of atherosclerotic lesions of the internal carotid. |
| first_indexed | 2024-03-10T21:04:29Z |
| format | Article |
| id | doaj.art-26ced6161df04540a7fa6e3f112d616e |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T21:04:29Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-26ced6161df04540a7fa6e3f112d616e2023-11-19T17:17:16ZengMDPI AGMedicina1010-660X1648-91442023-10-015910179010.3390/medicina59101790IL-1 Beta—A Biomarker for Ischemic Stroke Prognosis and Atherosclerotic Lesions of the Internal Carotid ArteryMaria-Gabriela Catană0Ioan-Adrian Popențiu1Mădălina Văleanu2Corina Roman-Filip3Romeo-Gabriel Mihăilă4Faculty of Medicine, Lucian Blaga University of Sibiu, Izvorului Street, 550169 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University of Sibiu, Izvorului Street, 550169 Sibiu, RomaniaDepartment of Medical Informatics and Biostatistics, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, 7 Horea Street, 400174 Cluj-Napoca, RomaniaFaculty of Medicine, Lucian Blaga University of Sibiu, Izvorului Street, 550169 Sibiu, RomaniaFaculty of Medicine, Lucian Blaga University of Sibiu, Izvorului Street, 550169 Sibiu, Romania<i>Background and Objectives:</i> Stroke is a leading cause of mortality and morbidity worldwide. Treatment of this pathology is still under development and its risk factors remain to be determined. Therefore, we aim to determine the role of interleukin-1 beta in atherosclerotic lesions of the internal carotid artery as a risk factor for stroke and the role of this biomarker in stroke prognosis. <i>Materials and Methods</i>: This study enrolled 56 patients diagnosed with ischemic stroke in the anterior vascular territory (AVT) and posterior vascular territory (PVT). All the patients had venous blood collected at admission and 7 days after the onset of the cerebral ischemia in order to determine the plasma concentration of interleukin-1 beta. At the same time, an extracranial carotid ultrasound was performed. <i>Results</i>: The interleukin-1 beta collected at admission was positively correlated with the NIHSS at admission (Pearson index 0.424), and both measurements were correlated with carotid stenosis (Spearmen correlation index of 0.529 and 0.653, respectively). <i>Conclusions</i>: Interleukin-1 beta could be a reliable biomarker for stroke prognosis and the development of atherosclerotic lesions of the internal carotid.https://www.mdpi.com/1648-9144/59/10/1790inflammationstrokeatheromatosisbiomarkerinterleukin-1 beta |
| spellingShingle | Maria-Gabriela Catană Ioan-Adrian Popențiu Mădălina Văleanu Corina Roman-Filip Romeo-Gabriel Mihăilă IL-1 Beta—A Biomarker for Ischemic Stroke Prognosis and Atherosclerotic Lesions of the Internal Carotid Artery Medicina inflammation stroke atheromatosis biomarker interleukin-1 beta |
| title | IL-1 Beta—A Biomarker for Ischemic Stroke Prognosis and Atherosclerotic Lesions of the Internal Carotid Artery |
| title_full | IL-1 Beta—A Biomarker for Ischemic Stroke Prognosis and Atherosclerotic Lesions of the Internal Carotid Artery |
| title_fullStr | IL-1 Beta—A Biomarker for Ischemic Stroke Prognosis and Atherosclerotic Lesions of the Internal Carotid Artery |
| title_full_unstemmed | IL-1 Beta—A Biomarker for Ischemic Stroke Prognosis and Atherosclerotic Lesions of the Internal Carotid Artery |
| title_short | IL-1 Beta—A Biomarker for Ischemic Stroke Prognosis and Atherosclerotic Lesions of the Internal Carotid Artery |
| title_sort | il 1 beta a biomarker for ischemic stroke prognosis and atherosclerotic lesions of the internal carotid artery |
| topic | inflammation stroke atheromatosis biomarker interleukin-1 beta |
| url | https://www.mdpi.com/1648-9144/59/10/1790 |
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