Effect of nigella sativa on IL-10 in MB leprosy that received MDT-WHO therapy
Background: Leprosy, a chronic infectious disease presents a broad clinical spectrum that is correlated with the immunological response of the patient, mainly related to Th1/Th2 cells. IL-10 is a major cytokine produced by Th2 cells inhibits imunostimulatory cytokine produced by Th1 cells. Suppressi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Diponegoro University
2016-07-01
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| Series: | Journal of Biomedicine and Translational Research |
| Subjects: | |
| Online Access: | http://ejournal2.undip.ac.id/index.php/jbtr/article/view/438 |
| _version_ | 1818149028572954624 |
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| author | Febrina Primasanti Lewie Suryaatmadja R. Sri Djoko |
| author_facet | Febrina Primasanti Lewie Suryaatmadja R. Sri Djoko |
| author_sort | Febrina Primasanti |
| collection | DOAJ |
| description | Background: Leprosy, a chronic infectious disease presents a broad clinical spectrum that is correlated with the immunological response of the patient, mainly related to Th1/Th2 cells. IL-10 is a major cytokine produced by Th2 cells inhibits imunostimulatory cytokine produced by Th1 cells. Suppressive effects of IL-10 in monocytes and cytokine synthesis by Th1 cells presumably because IL-10 has a general suppressive effect on immune function. Nigella sativa has a potent potentiating effect on cellular immunity through suppression of Th2 cells and IL-10, resulting in potentiation of Th1 cells.
Method: The study design is a randomized pretest and posttest controlled design involving 40 subjects of MB leprosy patients. Serum levels of IL-10 were measured by ELISA.
Result: The mean decrease in serum levels of IL-10 (IL-10 delta) in the treatment group (average fell 3.12 pg/ml) is greater than the control group (average rose 0.21 pg/ml), where the difference is statistically significant (p = 0.029). Nigella sativa giving significant correlation with a decrease in IL-10 compared to the control group (p=0.044, OR: 10.23).
Conclusion: supplementation of Nigella sativa 3 x 1000 mg for 2 months in patients with MB leprosy can reduce levels of IL-10, thus increasing the cellular immune response in patients with MB leprosy. |
| first_indexed | 2024-12-11T13:00:31Z |
| format | Article |
| id | doaj.art-26cf1b49280b457086f24f86c13e5998 |
| institution | Directory Open Access Journal |
| issn | 2503-2178 |
| language | English |
| last_indexed | 2024-12-11T13:00:31Z |
| publishDate | 2016-07-01 |
| publisher | Diponegoro University |
| record_format | Article |
| series | Journal of Biomedicine and Translational Research |
| spelling | doaj.art-26cf1b49280b457086f24f86c13e59982022-12-22T01:06:29ZengDiponegoro UniversityJournal of Biomedicine and Translational Research2503-21782016-07-01215910.14710/jbtr.v2i1.438475Effect of nigella sativa on IL-10 in MB leprosy that received MDT-WHO therapyFebrina Primasanti0Lewie Suryaatmadja1R. Sri Djoko2Faculty of Medicine Diponegoro University/ Dr. Kariadi Hospital Semarang, IndonesiaFaculty of Medicine Diponegoro University/ Dr. Kariadi Hospital Semarang, IndonesiaFaculty of Medicine Diponegoro University/ Dr. Kariadi Hospital Semarang, IndonesiaBackground: Leprosy, a chronic infectious disease presents a broad clinical spectrum that is correlated with the immunological response of the patient, mainly related to Th1/Th2 cells. IL-10 is a major cytokine produced by Th2 cells inhibits imunostimulatory cytokine produced by Th1 cells. Suppressive effects of IL-10 in monocytes and cytokine synthesis by Th1 cells presumably because IL-10 has a general suppressive effect on immune function. Nigella sativa has a potent potentiating effect on cellular immunity through suppression of Th2 cells and IL-10, resulting in potentiation of Th1 cells. Method: The study design is a randomized pretest and posttest controlled design involving 40 subjects of MB leprosy patients. Serum levels of IL-10 were measured by ELISA. Result: The mean decrease in serum levels of IL-10 (IL-10 delta) in the treatment group (average fell 3.12 pg/ml) is greater than the control group (average rose 0.21 pg/ml), where the difference is statistically significant (p = 0.029). Nigella sativa giving significant correlation with a decrease in IL-10 compared to the control group (p=0.044, OR: 10.23). Conclusion: supplementation of Nigella sativa 3 x 1000 mg for 2 months in patients with MB leprosy can reduce levels of IL-10, thus increasing the cellular immune response in patients with MB leprosy.http://ejournal2.undip.ac.id/index.php/jbtr/article/view/438MB Leprosy, Nigella sativa, IL-10 |
| spellingShingle | Febrina Primasanti Lewie Suryaatmadja R. Sri Djoko Effect of nigella sativa on IL-10 in MB leprosy that received MDT-WHO therapy Journal of Biomedicine and Translational Research MB Leprosy, Nigella sativa, IL-10 |
| title | Effect of nigella sativa on IL-10 in MB leprosy that received MDT-WHO therapy |
| title_full | Effect of nigella sativa on IL-10 in MB leprosy that received MDT-WHO therapy |
| title_fullStr | Effect of nigella sativa on IL-10 in MB leprosy that received MDT-WHO therapy |
| title_full_unstemmed | Effect of nigella sativa on IL-10 in MB leprosy that received MDT-WHO therapy |
| title_short | Effect of nigella sativa on IL-10 in MB leprosy that received MDT-WHO therapy |
| title_sort | effect of nigella sativa on il 10 in mb leprosy that received mdt who therapy |
| topic | MB Leprosy, Nigella sativa, IL-10 |
| url | http://ejournal2.undip.ac.id/index.php/jbtr/article/view/438 |
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