Recent progress in the development of nanomaterials targeting multiple cancer metabolic pathways: a review of mechanistic approaches for cancer treatment
AbstractCancer is a very heterogeneous disease, and uncontrolled cell division is the main characteristic of cancer. Cancerous cells need a high nutrition intake to enable aberrant growth and survival. To do so, cancer cells modify metabolic pathways to produce energy and anabolic precursors and pre...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/10717544.2022.2144541 |
| _version_ | 1797260979659079680 |
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| author | Ling Zhang Bing-Zhong Zhai Yue-Jin Wu Yin Wang |
| author_facet | Ling Zhang Bing-Zhong Zhai Yue-Jin Wu Yin Wang |
| author_sort | Ling Zhang |
| collection | DOAJ |
| description | AbstractCancer is a very heterogeneous disease, and uncontrolled cell division is the main characteristic of cancer. Cancerous cells need a high nutrition intake to enable aberrant growth and survival. To do so, cancer cells modify metabolic pathways to produce energy and anabolic precursors and preserve redox balance. Due to the importance of metabolic pathways in tumor growth and malignant transformation, metabolic pathways have also been given promising perspectives for cancer treatment, providing more effective treatment strategies, and target-specific with minimum side effects. Metabolism-based therapeutic nanomaterials for targeted cancer treatment are a promising option. Numerous types of nanoparticles (NPs) are employed in the research and analysis of various cancer therapies. The current review focuses on cutting-edge strategies and current cancer therapy methods based on nanomaterials that target various cancer metabolisms. Additionally, it highlighted the primacy of NPs-based cancer therapies over traditional ones, the challenges, and the future potential. |
| first_indexed | 2024-03-08T23:31:28Z |
| format | Article |
| id | doaj.art-26d1f9ca28ab4ae494236662c269cd21 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-04-24T23:33:56Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-26d1f9ca28ab4ae494236662c269cd212024-03-15T14:22:17ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642023-12-0130111810.1080/10717544.2022.2144541Recent progress in the development of nanomaterials targeting multiple cancer metabolic pathways: a review of mechanistic approaches for cancer treatmentLing Zhang0Bing-Zhong Zhai1Yue-Jin Wu2Yin Wang3Reproductive Medicine Center, Department of Reproductive Endocrinology, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 310014, ChinaHangzhou Municipal Center for Disease Control and Prevention, Hangzhou, Zhejiang, 310021, ChinaInstitute of Food Science and Engineering, Hangzhou Medical College, Hangzhou, Zhejiang, 310013, ChinaInstitute of Food Science and Engineering, Hangzhou Medical College, Hangzhou, Zhejiang, 310013, ChinaAbstractCancer is a very heterogeneous disease, and uncontrolled cell division is the main characteristic of cancer. Cancerous cells need a high nutrition intake to enable aberrant growth and survival. To do so, cancer cells modify metabolic pathways to produce energy and anabolic precursors and preserve redox balance. Due to the importance of metabolic pathways in tumor growth and malignant transformation, metabolic pathways have also been given promising perspectives for cancer treatment, providing more effective treatment strategies, and target-specific with minimum side effects. Metabolism-based therapeutic nanomaterials for targeted cancer treatment are a promising option. Numerous types of nanoparticles (NPs) are employed in the research and analysis of various cancer therapies. The current review focuses on cutting-edge strategies and current cancer therapy methods based on nanomaterials that target various cancer metabolisms. Additionally, it highlighted the primacy of NPs-based cancer therapies over traditional ones, the challenges, and the future potential.https://www.tandfonline.com/doi/10.1080/10717544.2022.2144541Cancer metabolismsnanoparticlesanticancer drugsnanomedicinedrug delivery |
| spellingShingle | Ling Zhang Bing-Zhong Zhai Yue-Jin Wu Yin Wang Recent progress in the development of nanomaterials targeting multiple cancer metabolic pathways: a review of mechanistic approaches for cancer treatment Drug Delivery Cancer metabolisms nanoparticles anticancer drugs nanomedicine drug delivery |
| title | Recent progress in the development of nanomaterials targeting multiple cancer metabolic pathways: a review of mechanistic approaches for cancer treatment |
| title_full | Recent progress in the development of nanomaterials targeting multiple cancer metabolic pathways: a review of mechanistic approaches for cancer treatment |
| title_fullStr | Recent progress in the development of nanomaterials targeting multiple cancer metabolic pathways: a review of mechanistic approaches for cancer treatment |
| title_full_unstemmed | Recent progress in the development of nanomaterials targeting multiple cancer metabolic pathways: a review of mechanistic approaches for cancer treatment |
| title_short | Recent progress in the development of nanomaterials targeting multiple cancer metabolic pathways: a review of mechanistic approaches for cancer treatment |
| title_sort | recent progress in the development of nanomaterials targeting multiple cancer metabolic pathways a review of mechanistic approaches for cancer treatment |
| topic | Cancer metabolisms nanoparticles anticancer drugs nanomedicine drug delivery |
| url | https://www.tandfonline.com/doi/10.1080/10717544.2022.2144541 |
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