Development and Characterization of Nanobodies Targeting the Kupffer Cell

Development and Characterization of Nanobodies Targeting the Kupffer Cell

Nanobodies that are derived from single-chain antibodies of camelids have served as powerful tools in diagnostics, therapeutics and investigation of membrane receptors' structure and function. In this study, we developed a series of nanobodies by a phage display screening building from lymphocy...

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Bibliographic Details
Main Authors: Fang Zheng, Jinhong Zhou, Zhenlin Ouyang, Jiaxin Zhang, Xinyi Wang, Serge Muyldermans, Jo Van Ginderachter, Nick Devoogdt, Yurong Wen, Steve Schoonooghe, Geert Raes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
Clec4F
nanobody
epitope binning
x-ray crystallography
Kupffer cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.641819/full

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