Combined Toxicity of the Most Common Indoor Aspergilli
The most common Aspergilli isolated from indoor air samples from occupied buildings and a grain mill were extracted and analyzed for their combined (<i>Flavi</i> + <i>Nigri</i>, <i>Versicolores</i> + <i>Nigri</i>) cytotoxic, genotoxic and pro-inflammat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/12/3/459 |
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| author | Daniela Jakšić Dubravko Jelić Nevenka Kopjar Maja Šegvić Klarić |
| author_facet | Daniela Jakšić Dubravko Jelić Nevenka Kopjar Maja Šegvić Klarić |
| author_sort | Daniela Jakšić |
| collection | DOAJ |
| description | The most common Aspergilli isolated from indoor air samples from occupied buildings and a grain mill were extracted and analyzed for their combined (<i>Flavi</i> + <i>Nigri</i>, <i>Versicolores</i> + <i>Nigri</i>) cytotoxic, genotoxic and pro-inflammatory properties on human adenocarcinoma cells (A549) and monocytic leukemia cells induced in macrophages (THP-1 macrophages). Metabolite mixtures from the Aspergilli series <i>Nigri</i> increase the cytotoxic and genotoxic potency of <i>Flavi</i> extracts in A549 cells suggesting additive and/or synergistic effects, while antagonizing the cytotoxic potency of <i>Versicolores</i> extracts in THP-1 macrophages and genotoxicity in A549 cells. All tested combinations significantly decreased IL-5 and IL-17, while IL-1β, TNF-α and IL-6 relative concentrations were increased. Exploring the toxicity of extracted Aspergilli deepens the understanding of intersections and interspecies differences in events of chronic exposure to their inhalable mycoparticles. |
| first_indexed | 2024-03-11T06:02:59Z |
| format | Article |
| id | doaj.art-26d247574d0c4b548ba2e245ae1f0acd |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-11T06:02:59Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-26d247574d0c4b548ba2e245ae1f0acd2023-11-17T13:10:15ZengMDPI AGPathogens2076-08172023-03-0112345910.3390/pathogens12030459Combined Toxicity of the Most Common Indoor AspergilliDaniela Jakšić0Dubravko Jelić1Nevenka Kopjar2Maja Šegvić Klarić3Department of Microbiology, Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, CroatiaSelvita, 10000 Zagreb, CroatiaInstitute for Medical Research and Occupational Health, 10000 Zagreb, CroatiaDepartment of Microbiology, Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, CroatiaThe most common Aspergilli isolated from indoor air samples from occupied buildings and a grain mill were extracted and analyzed for their combined (<i>Flavi</i> + <i>Nigri</i>, <i>Versicolores</i> + <i>Nigri</i>) cytotoxic, genotoxic and pro-inflammatory properties on human adenocarcinoma cells (A549) and monocytic leukemia cells induced in macrophages (THP-1 macrophages). Metabolite mixtures from the Aspergilli series <i>Nigri</i> increase the cytotoxic and genotoxic potency of <i>Flavi</i> extracts in A549 cells suggesting additive and/or synergistic effects, while antagonizing the cytotoxic potency of <i>Versicolores</i> extracts in THP-1 macrophages and genotoxicity in A549 cells. All tested combinations significantly decreased IL-5 and IL-17, while IL-1β, TNF-α and IL-6 relative concentrations were increased. Exploring the toxicity of extracted Aspergilli deepens the understanding of intersections and interspecies differences in events of chronic exposure to their inhalable mycoparticles.https://www.mdpi.com/2076-0817/12/3/459cytotoxicitygenotoxicityproinflammatory cytokinesseries <i>Nigri</i>section <i>Flavi</i>series <i>Versicolores</i> |
| spellingShingle | Daniela Jakšić Dubravko Jelić Nevenka Kopjar Maja Šegvić Klarić Combined Toxicity of the Most Common Indoor Aspergilli Pathogens cytotoxicity genotoxicity proinflammatory cytokines series <i>Nigri</i> section <i>Flavi</i> series <i>Versicolores</i> |
| title | Combined Toxicity of the Most Common Indoor Aspergilli |
| title_full | Combined Toxicity of the Most Common Indoor Aspergilli |
| title_fullStr | Combined Toxicity of the Most Common Indoor Aspergilli |
| title_full_unstemmed | Combined Toxicity of the Most Common Indoor Aspergilli |
| title_short | Combined Toxicity of the Most Common Indoor Aspergilli |
| title_sort | combined toxicity of the most common indoor aspergilli |
| topic | cytotoxicity genotoxicity proinflammatory cytokines series <i>Nigri</i> section <i>Flavi</i> series <i>Versicolores</i> |
| url | https://www.mdpi.com/2076-0817/12/3/459 |
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