Time-Dependent Protective and Pro-Resolving Effects of FPR2 Agonists on Lipopolysaccharide-Exposed Microglia Cells Involve Inhibition of NF-κB and MAPKs Pathways

Time-Dependent Protective and Pro-Resolving Effects of FPR2 Agonists on Lipopolysaccharide-Exposed Microglia Cells Involve Inhibition of NF-κB and MAPKs Pathways

Prolonged or excessive microglial activation may lead to disturbances in the resolution of inflammation (RoI). The importance of specialized pro-resolving lipid mediators (SPMs) in RoI has been highlighted. Among them, lipoxins (LXA4) and aspirin-triggered lipoxin A4 (AT-LXA4) mediate beneficial res...

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Bibliographic Details
Main Authors: Kinga Tylek, Ewa Trojan, Monika Leśkiewicz, Magdalena Regulska, Natalia Bryniarska, Katarzyna Curzytek, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
microglia
lipopolysaccharide
lipoxin A4
aspirin-triggered lipoxin A4
MR-39
formyl peptide receptor 2
Online Access:https://www.mdpi.com/2073-4409/10/9/2373

Internet

https://www.mdpi.com/2073-4409/10/9/2373

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