An Inventory of CiaR-Dependent Small Regulatory RNAs in Streptococci
Bacteria adapt to the different environments encountered by rapid and tightly controlled regulations involving complex networks. A first line of control is transcriptional with regulators such as two-component systems (TCSs) that respond to physical and chemical perturbations. It is followed by post...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.669396/full |
| _version_ | 1818832365964754944 |
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| author | Nancy Jabbour Marie-Frédérique Lartigue Marie-Frédérique Lartigue |
| author_facet | Nancy Jabbour Marie-Frédérique Lartigue Marie-Frédérique Lartigue |
| author_sort | Nancy Jabbour |
| collection | DOAJ |
| description | Bacteria adapt to the different environments encountered by rapid and tightly controlled regulations involving complex networks. A first line of control is transcriptional with regulators such as two-component systems (TCSs) that respond to physical and chemical perturbations. It is followed by posttranscriptional regulations in which small regulatory RNAs (sRNAs) may affect RNA translation. Streptococci are opportunistic pathogens for humans and farm animals. The TCS CiaRH is highly conserved among this genus and crucial in bacterial survival under stressful conditions. In several streptococcal species, some sRNAs belong to the CiaRH regulon and are called csRNAs for cia-dependent sRNAs. In this review, we start by focusing on the Streptococcus species harboring a CiaRH TCS. Then the role of CiaRH in streptococcal pathogenesis is discussed in the context of recent studies. Finally, we give an overview of csRNAs and their functions in Streptococci with a focus on their importance in bacterial adaptation and virulence. |
| first_indexed | 2024-12-19T02:01:53Z |
| format | Article |
| id | doaj.art-26d2c3e462b2414680a8565e6738202d |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-19T02:01:53Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-26d2c3e462b2414680a8565e6738202d2022-12-21T20:41:01ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-05-011210.3389/fmicb.2021.669396669396An Inventory of CiaR-Dependent Small Regulatory RNAs in StreptococciNancy Jabbour0Marie-Frédérique Lartigue1Marie-Frédérique Lartigue2Université de Tours, INRAE, ISP, Tours, FranceUniversité de Tours, INRAE, ISP, Tours, FranceCentre Hospitalier Universitaire de Tours, Service de Bactériologie, Virologie, et Hygiène Hospitalière, Tours, FranceBacteria adapt to the different environments encountered by rapid and tightly controlled regulations involving complex networks. A first line of control is transcriptional with regulators such as two-component systems (TCSs) that respond to physical and chemical perturbations. It is followed by posttranscriptional regulations in which small regulatory RNAs (sRNAs) may affect RNA translation. Streptococci are opportunistic pathogens for humans and farm animals. The TCS CiaRH is highly conserved among this genus and crucial in bacterial survival under stressful conditions. In several streptococcal species, some sRNAs belong to the CiaRH regulon and are called csRNAs for cia-dependent sRNAs. In this review, we start by focusing on the Streptococcus species harboring a CiaRH TCS. Then the role of CiaRH in streptococcal pathogenesis is discussed in the context of recent studies. Finally, we give an overview of csRNAs and their functions in Streptococci with a focus on their importance in bacterial adaptation and virulence.https://www.frontiersin.org/articles/10.3389/fmicb.2021.669396/fullStreptococciregulationCiaRHregulatory RNAscsRNAs |
| spellingShingle | Nancy Jabbour Marie-Frédérique Lartigue Marie-Frédérique Lartigue An Inventory of CiaR-Dependent Small Regulatory RNAs in Streptococci Frontiers in Microbiology Streptococci regulation CiaRH regulatory RNAs csRNAs |
| title | An Inventory of CiaR-Dependent Small Regulatory RNAs in Streptococci |
| title_full | An Inventory of CiaR-Dependent Small Regulatory RNAs in Streptococci |
| title_fullStr | An Inventory of CiaR-Dependent Small Regulatory RNAs in Streptococci |
| title_full_unstemmed | An Inventory of CiaR-Dependent Small Regulatory RNAs in Streptococci |
| title_short | An Inventory of CiaR-Dependent Small Regulatory RNAs in Streptococci |
| title_sort | inventory of ciar dependent small regulatory rnas in streptococci |
| topic | Streptococci regulation CiaRH regulatory RNAs csRNAs |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.669396/full |
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