Value of electrophysiological indicators in differential diagnosis of parkinson's disease and multiple system atrophy
Abstract Background We evaluated the value of electrophysiological indicators by external anal sphincter electromyography (EAS-EMG), sympathetic skin response (SSR), R-R interval variation (RRIV), and Bulbocavernosus Reflex (BCR) in differential diagnosis of multiple system atrophy (MSA) and Parkins...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-023-03131-8 |
| _version_ | 1827983770280525824 |
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| author | Wangwang Hu Yifan Cheng Jie Pan Xun Wang Shaojing Li Zijian Fan Bei Shao Xiaoting Niu |
| author_facet | Wangwang Hu Yifan Cheng Jie Pan Xun Wang Shaojing Li Zijian Fan Bei Shao Xiaoting Niu |
| author_sort | Wangwang Hu |
| collection | DOAJ |
| description | Abstract Background We evaluated the value of electrophysiological indicators by external anal sphincter electromyography (EAS-EMG), sympathetic skin response (SSR), R-R interval variation (RRIV), and Bulbocavernosus Reflex (BCR) in differential diagnosis of multiple system atrophy (MSA) and Parkinson’s disease (PD). Methods A total of 41 patients with MSA and 32 patients with PD were enrolled. The electrophysiological changes of autonomic dysfunction were assessed with BCR, EAS-EMG, SSR, and RRIV, and the abnormal rate of each indicator was calculated. The diagnostic value of each indicator was analyzed with ROC curve. Results The incidence rate of autonomic dysfunction in MSA group was significantly higher than that in PD group (p < 0.05). The abnormal rates of BCR and EAS-EMG indicators in MSA group were higher than those in PD group (p < 0.05). The abnormal rates of SSR and RRIV indicators in MSA group and PD group were high; however, there was no significant difference between MSA and PD groups (p > 0.05). The sensitivity of BCR combined with EAS-EMG indicators in differential diagnosis of MSA and PD were 92.3% in males and 86.7% in females, respectively, and the specificity was 72.7% in males and 90% in females, respectively. Conclusions Combined analysis of BCR and EAS-EMG has high sensitivity and specificity for differential diagnosis of MSA and PD. |
| first_indexed | 2024-04-09T22:51:18Z |
| format | Article |
| id | doaj.art-26d419dd460d4022ac56c78833f38d74 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-09T22:51:18Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-26d419dd460d4022ac56c78833f38d742023-03-22T11:38:25ZengBMCBMC Neurology1471-23772023-03-012311910.1186/s12883-023-03131-8Value of electrophysiological indicators in differential diagnosis of parkinson's disease and multiple system atrophyWangwang Hu0Yifan Cheng1Jie Pan2Xun Wang3Shaojing Li4Zijian Fan5Bei Shao6Xiaoting Niu7Department of Rehabilitation Medicine, Ningbo Medical Center Li Huili HospitalCenter for Rehabilitation Medicine, Department of Neurology, Zhejiang Provincial People’s Hospital, Affiliated People’s HospitalDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Neurology, Taizhou Central HospitalDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical UniversityAbstract Background We evaluated the value of electrophysiological indicators by external anal sphincter electromyography (EAS-EMG), sympathetic skin response (SSR), R-R interval variation (RRIV), and Bulbocavernosus Reflex (BCR) in differential diagnosis of multiple system atrophy (MSA) and Parkinson’s disease (PD). Methods A total of 41 patients with MSA and 32 patients with PD were enrolled. The electrophysiological changes of autonomic dysfunction were assessed with BCR, EAS-EMG, SSR, and RRIV, and the abnormal rate of each indicator was calculated. The diagnostic value of each indicator was analyzed with ROC curve. Results The incidence rate of autonomic dysfunction in MSA group was significantly higher than that in PD group (p < 0.05). The abnormal rates of BCR and EAS-EMG indicators in MSA group were higher than those in PD group (p < 0.05). The abnormal rates of SSR and RRIV indicators in MSA group and PD group were high; however, there was no significant difference between MSA and PD groups (p > 0.05). The sensitivity of BCR combined with EAS-EMG indicators in differential diagnosis of MSA and PD were 92.3% in males and 86.7% in females, respectively, and the specificity was 72.7% in males and 90% in females, respectively. Conclusions Combined analysis of BCR and EAS-EMG has high sensitivity and specificity for differential diagnosis of MSA and PD.https://doi.org/10.1186/s12883-023-03131-8Multiple system atrophyParkinson's diseaseExternal anal sphincter electromyographyBulbocavernosus reflex |
| spellingShingle | Wangwang Hu Yifan Cheng Jie Pan Xun Wang Shaojing Li Zijian Fan Bei Shao Xiaoting Niu Value of electrophysiological indicators in differential diagnosis of parkinson's disease and multiple system atrophy BMC Neurology Multiple system atrophy Parkinson's disease External anal sphincter electromyography Bulbocavernosus reflex |
| title | Value of electrophysiological indicators in differential diagnosis of parkinson's disease and multiple system atrophy |
| title_full | Value of electrophysiological indicators in differential diagnosis of parkinson's disease and multiple system atrophy |
| title_fullStr | Value of electrophysiological indicators in differential diagnosis of parkinson's disease and multiple system atrophy |
| title_full_unstemmed | Value of electrophysiological indicators in differential diagnosis of parkinson's disease and multiple system atrophy |
| title_short | Value of electrophysiological indicators in differential diagnosis of parkinson's disease and multiple system atrophy |
| title_sort | value of electrophysiological indicators in differential diagnosis of parkinson s disease and multiple system atrophy |
| topic | Multiple system atrophy Parkinson's disease External anal sphincter electromyography Bulbocavernosus reflex |
| url | https://doi.org/10.1186/s12883-023-03131-8 |
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