Segregated circuits for phonemic and semantic fluency: A novel patient-tailored disconnection study
Phonemic and semantic fluency are neuropsychological tests widely used to assess patients’ language and executive abilities and are highly sensitive tests in detecting language deficits in glioma patients. However, the networks that are involved in these tasks could be distinct and suggesting either...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158222002145 |
| _version_ | 1798042581736620032 |
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| author | Luca Zigiotto Laura Vavassori Luciano Annicchiarico Francesco Corsini Paolo Avesani Umberto Rozzanigo Silvio Sarubbo Costanza Papagno |
| author_facet | Luca Zigiotto Laura Vavassori Luciano Annicchiarico Francesco Corsini Paolo Avesani Umberto Rozzanigo Silvio Sarubbo Costanza Papagno |
| author_sort | Luca Zigiotto |
| collection | DOAJ |
| description | Phonemic and semantic fluency are neuropsychological tests widely used to assess patients’ language and executive abilities and are highly sensitive tests in detecting language deficits in glioma patients. However, the networks that are involved in these tasks could be distinct and suggesting either a frontal (phonemic) or temporal (semantic) involvement.42 right-handed patients (26 male, mean age = 52.5 years, SD=±13.3) were included in this retrospective study. Patients underwent awake (54.8%) or asleep (45.2%) surgery for low-grade (16.7%) or high-grade-glioma (83.3%) in the frontal (64.3%) or temporal lobe (35.7%) of the left (50%) or right (50%) hemisphere. Pre-operative tractography was reconstructed for each patient, with segmentation of the inferior fronto-occipital fasciculus (IFOF), arcuate fasciculus (AF), uncinate fasciculus (UF), inferior longitudinal fasciculus (ILF), third branch of the superior longitudinal fasciculus (SLF-III), frontal aslant tract (FAT), and cortico-spinal tract (CST). Post-operative percentage of damage and disconnection of each tract, based on the patients’ surgical cavities, were correlated with verbal fluencies scores at one week and one month after surgery. Analyses of differences between fluency scores at these timepoints (before surgery, one week and one month after surgery) were performed; lesion-symptom mapping was used to identify the correlation between cortical areas and post-operative scores.Immediately after surgery, a transient impairment of verbal fluency was observed, that improved within a month. Left hemisphere lesions were related to a worse verbal fluency performance, being a damage to the left superior frontal or temporal gyri associated with phonemic or semantic fluency deficit, respectively. At a subcortical level, disconnection analyses revealed that fluency scores were associated to the involvement of the left FAT and the left frontal part of the IFOF for phonemic fluency, and the association was still present one month after surgery. For semantic fluency, the correlation between post-surgery performance emerged for the left AF, UF, ILF and the temporal part of the IFOF, but disappeared at the follow-up.This approach based on the patients’ pre-operative tractography, allowed to trace for the first time a dissociation between white matter pathways integrity and verbal fluency after surgery for glioma resection. Our results confirm the involvement of a frontal anterior pathway for phonemic fluency and a ventral temporal pathway for semantic fluency. Finally, our longitudinal results suggest that the frontal executive pathway requires a longer interval to recover compared to the semantic one. |
| first_indexed | 2024-04-11T22:37:33Z |
| format | Article |
| id | doaj.art-26d585e12804424ab526df6b7a357b1b |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-11T22:37:33Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-26d585e12804424ab526df6b7a357b1b2022-12-22T03:59:10ZengElsevierNeuroImage: Clinical2213-15822022-01-0136103149Segregated circuits for phonemic and semantic fluency: A novel patient-tailored disconnection studyLuca Zigiotto0Laura Vavassori1Luciano Annicchiarico2Francesco Corsini3Paolo Avesani4Umberto Rozzanigo5Silvio Sarubbo6Costanza Papagno7Department of Neurosurgery, “S. Chiara” Hospital, Azienda Provinciale per i Servizi Sanitari, Trento 39122, Italy; Structural and Functional Connectivity Lab Project, “S. Chiara” Hospital, Azienda Provinciale per i Servizi Sanitari, Trento 38122, Italy; Department of Psychology, “S. Chiara” Hospital, Azienda Provinciale per i Servizi Sanitari, Trento 38122, ItalyDepartment of Neurosurgery, “S. Chiara” Hospital, Azienda Provinciale per i Servizi Sanitari, Trento 39122, Italy; Structural and Functional Connectivity Lab Project, “S. Chiara” Hospital, Azienda Provinciale per i Servizi Sanitari, Trento 38122, Italy; Center for Mind/Brain Sciences – CIMeC, University of Trento, Rovereto 38068, ItalyDepartment of Neurosurgery, “S. Chiara” Hospital, Azienda Provinciale per i Servizi Sanitari, Trento 39122, Italy; Structural and Functional Connectivity Lab Project, “S. Chiara” Hospital, Azienda Provinciale per i Servizi Sanitari, Trento 38122, ItalyDepartment of Neurosurgery, “S. Chiara” Hospital, Azienda Provinciale per i Servizi Sanitari, Trento 39122, Italy; Structural and Functional Connectivity Lab Project, “S. Chiara” Hospital, Azienda Provinciale per i Servizi Sanitari, Trento 38122, ItalyNeuroinformatics Laboratory (NiLab), Bruno Kessler Foundation (FBK), Trento 38123, ItalyDepartment of Neuroradiology, “S. Chiara” Hospital, Azienda Provinciale per i Servizi Sanitari, Trento 38122, ItalyDepartment of Neurosurgery, “S. Chiara” Hospital, Azienda Provinciale per i Servizi Sanitari, Trento 39122, Italy; Structural and Functional Connectivity Lab Project, “S. Chiara” Hospital, Azienda Provinciale per i Servizi Sanitari, Trento 38122, ItalyCeRiN (Center for Cognitive Neurorehabilitation), Center for Mind/Brain Sciences (CIMeC), University of Trento, Rovereto, Trento 38068, Italy; Corresponding author at: CeRiN (Center for Cognitive Neurorehabilitation), Center for Mind/Brain Sciences (CIMeC), University of Trento, Trade Center Via Matteo del Ben, 5/b Rovereto, Trento 38068, Italy.Phonemic and semantic fluency are neuropsychological tests widely used to assess patients’ language and executive abilities and are highly sensitive tests in detecting language deficits in glioma patients. However, the networks that are involved in these tasks could be distinct and suggesting either a frontal (phonemic) or temporal (semantic) involvement.42 right-handed patients (26 male, mean age = 52.5 years, SD=±13.3) were included in this retrospective study. Patients underwent awake (54.8%) or asleep (45.2%) surgery for low-grade (16.7%) or high-grade-glioma (83.3%) in the frontal (64.3%) or temporal lobe (35.7%) of the left (50%) or right (50%) hemisphere. Pre-operative tractography was reconstructed for each patient, with segmentation of the inferior fronto-occipital fasciculus (IFOF), arcuate fasciculus (AF), uncinate fasciculus (UF), inferior longitudinal fasciculus (ILF), third branch of the superior longitudinal fasciculus (SLF-III), frontal aslant tract (FAT), and cortico-spinal tract (CST). Post-operative percentage of damage and disconnection of each tract, based on the patients’ surgical cavities, were correlated with verbal fluencies scores at one week and one month after surgery. Analyses of differences between fluency scores at these timepoints (before surgery, one week and one month after surgery) were performed; lesion-symptom mapping was used to identify the correlation between cortical areas and post-operative scores.Immediately after surgery, a transient impairment of verbal fluency was observed, that improved within a month. Left hemisphere lesions were related to a worse verbal fluency performance, being a damage to the left superior frontal or temporal gyri associated with phonemic or semantic fluency deficit, respectively. At a subcortical level, disconnection analyses revealed that fluency scores were associated to the involvement of the left FAT and the left frontal part of the IFOF for phonemic fluency, and the association was still present one month after surgery. For semantic fluency, the correlation between post-surgery performance emerged for the left AF, UF, ILF and the temporal part of the IFOF, but disappeared at the follow-up.This approach based on the patients’ pre-operative tractography, allowed to trace for the first time a dissociation between white matter pathways integrity and verbal fluency after surgery for glioma resection. Our results confirm the involvement of a frontal anterior pathway for phonemic fluency and a ventral temporal pathway for semantic fluency. Finally, our longitudinal results suggest that the frontal executive pathway requires a longer interval to recover compared to the semantic one.http://www.sciencedirect.com/science/article/pii/S2213158222002145Phonemic fluencySemantic fluencyWhite matter fibersDisconnection analysesGlioma resectionNeural correlates |
| spellingShingle | Luca Zigiotto Laura Vavassori Luciano Annicchiarico Francesco Corsini Paolo Avesani Umberto Rozzanigo Silvio Sarubbo Costanza Papagno Segregated circuits for phonemic and semantic fluency: A novel patient-tailored disconnection study NeuroImage: Clinical Phonemic fluency Semantic fluency White matter fibers Disconnection analyses Glioma resection Neural correlates |
| title | Segregated circuits for phonemic and semantic fluency: A novel patient-tailored disconnection study |
| title_full | Segregated circuits for phonemic and semantic fluency: A novel patient-tailored disconnection study |
| title_fullStr | Segregated circuits for phonemic and semantic fluency: A novel patient-tailored disconnection study |
| title_full_unstemmed | Segregated circuits for phonemic and semantic fluency: A novel patient-tailored disconnection study |
| title_short | Segregated circuits for phonemic and semantic fluency: A novel patient-tailored disconnection study |
| title_sort | segregated circuits for phonemic and semantic fluency a novel patient tailored disconnection study |
| topic | Phonemic fluency Semantic fluency White matter fibers Disconnection analyses Glioma resection Neural correlates |
| url | http://www.sciencedirect.com/science/article/pii/S2213158222002145 |
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