Development of a Model Based on Physical Mechanisms for the Explanation of Drug Release: Application to Diclofenac Release from Polyurethane Films
In this study, we present a method for prediction of the drug-release profile based on the physical mechanisms that can intervene in drug release from a drug-carrier. The application presented here incorporates the effects of drug concentration and Reynolds number defining the circulating flow in th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/8/1230 |
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| author | Navideh Abbasnezhad Mohamed Kebdani Mohammadali Shirinbayan Stéphane Champmartin Abbas Tcharkhtchi Smaine Kouidri Farid Bakir |
| author_facet | Navideh Abbasnezhad Mohamed Kebdani Mohammadali Shirinbayan Stéphane Champmartin Abbas Tcharkhtchi Smaine Kouidri Farid Bakir |
| author_sort | Navideh Abbasnezhad |
| collection | DOAJ |
| description | In this study, we present a method for prediction of the drug-release profile based on the physical mechanisms that can intervene in drug release from a drug-carrier. The application presented here incorporates the effects of drug concentration and Reynolds number defining the circulating flow in the testing vein. The experimental data used relate to the release of diclofenac from samples of non-degradable polyurethane subjected to static and continuous flow. This case includes simultaneously three mechanisms: burst-release, diffusion and osmotic pressure, identified beforehand here as being able to contribute to the drug liberation. For this purpose, authors coded the Sequential Quadratic Programming Algorithm to solve the problem of non-linear optimization. The experimental data used to develop the mathematical model obtained from release studies carried out in water solution at 37 °C, for three concentrations of diclofenac and two water flow rates. We discuss the contribution of mechanisms and kinetics by considering two aforementioned parameters and, following that, we obtain the specific-model and compare the calculated results with the experimental results for the reserved cases. The results showed that drug percentage mostly affect the burst release, however flow rate has affected the osmotic release. In addition, release kinetics of all the mechanisms have increased by increasing the values of two considered parameters. |
| first_indexed | 2024-03-10T12:25:50Z |
| format | Article |
| id | doaj.art-26d65ee39407457eb393e3fcc74fcf72 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T12:25:50Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-26d65ee39407457eb393e3fcc74fcf722023-11-21T15:01:27ZengMDPI AGPolymers2073-43602021-04-01138123010.3390/polym13081230Development of a Model Based on Physical Mechanisms for the Explanation of Drug Release: Application to Diclofenac Release from Polyurethane FilmsNavideh Abbasnezhad0Mohamed Kebdani1Mohammadali Shirinbayan2Stéphane Champmartin3Abbas Tcharkhtchi4Smaine Kouidri5Farid Bakir6Arts et Metiers Institute of Technology, CNAM, LIFSE, HESAM University, F-75013 Paris, FranceArts et Metiers Institute of Technology, CNAM, LIFSE, HESAM University, F-75013 Paris, FranceArts et Metiers Institute of Technology, CNAM, LIFSE, HESAM University, F-75013 Paris, FranceArts et Metiers Institute of Technology, CNAM, LIFSE, HESAM University, F-75013 Paris, FranceArts et Metiers Institute of Technology, CNAM, PIMM, HESAM University, F-75013 Paris, FranceArts et Metiers Institute of Technology, CNAM, LIFSE, HESAM University, F-75013 Paris, FranceArts et Metiers Institute of Technology, CNAM, LIFSE, HESAM University, F-75013 Paris, FranceIn this study, we present a method for prediction of the drug-release profile based on the physical mechanisms that can intervene in drug release from a drug-carrier. The application presented here incorporates the effects of drug concentration and Reynolds number defining the circulating flow in the testing vein. The experimental data used relate to the release of diclofenac from samples of non-degradable polyurethane subjected to static and continuous flow. This case includes simultaneously three mechanisms: burst-release, diffusion and osmotic pressure, identified beforehand here as being able to contribute to the drug liberation. For this purpose, authors coded the Sequential Quadratic Programming Algorithm to solve the problem of non-linear optimization. The experimental data used to develop the mathematical model obtained from release studies carried out in water solution at 37 °C, for three concentrations of diclofenac and two water flow rates. We discuss the contribution of mechanisms and kinetics by considering two aforementioned parameters and, following that, we obtain the specific-model and compare the calculated results with the experimental results for the reserved cases. The results showed that drug percentage mostly affect the burst release, however flow rate has affected the osmotic release. In addition, release kinetics of all the mechanisms have increased by increasing the values of two considered parameters.https://www.mdpi.com/2073-4360/13/8/1230physical mechanismmodelingkineticdrug release |
| spellingShingle | Navideh Abbasnezhad Mohamed Kebdani Mohammadali Shirinbayan Stéphane Champmartin Abbas Tcharkhtchi Smaine Kouidri Farid Bakir Development of a Model Based on Physical Mechanisms for the Explanation of Drug Release: Application to Diclofenac Release from Polyurethane Films Polymers physical mechanism modeling kinetic drug release |
| title | Development of a Model Based on Physical Mechanisms for the Explanation of Drug Release: Application to Diclofenac Release from Polyurethane Films |
| title_full | Development of a Model Based on Physical Mechanisms for the Explanation of Drug Release: Application to Diclofenac Release from Polyurethane Films |
| title_fullStr | Development of a Model Based on Physical Mechanisms for the Explanation of Drug Release: Application to Diclofenac Release from Polyurethane Films |
| title_full_unstemmed | Development of a Model Based on Physical Mechanisms for the Explanation of Drug Release: Application to Diclofenac Release from Polyurethane Films |
| title_short | Development of a Model Based on Physical Mechanisms for the Explanation of Drug Release: Application to Diclofenac Release from Polyurethane Films |
| title_sort | development of a model based on physical mechanisms for the explanation of drug release application to diclofenac release from polyurethane films |
| topic | physical mechanism modeling kinetic drug release |
| url | https://www.mdpi.com/2073-4360/13/8/1230 |
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