Fucosylation in Urological Cancers
Fucosylation is an oligosaccharide modification that plays an important role in immune response and malignancy, and specific fucosyltransferases (FUTs) catalyze the three types of fucosylations: core-type, Lewis type, and H type. FUTs regulate cancer proliferation, invasiveness, and resistance to ch...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/24/13333 |
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| author | Kazutoshi Fujita Koji Hatano Mamoru Hashimoto Eisuke Tomiyama Eiji Miyoshi Norio Nonomura Hirotsugu Uemura |
| author_facet | Kazutoshi Fujita Koji Hatano Mamoru Hashimoto Eisuke Tomiyama Eiji Miyoshi Norio Nonomura Hirotsugu Uemura |
| author_sort | Kazutoshi Fujita |
| collection | DOAJ |
| description | Fucosylation is an oligosaccharide modification that plays an important role in immune response and malignancy, and specific fucosyltransferases (FUTs) catalyze the three types of fucosylations: core-type, Lewis type, and H type. FUTs regulate cancer proliferation, invasiveness, and resistance to chemotherapy by modifying the glycosylation of signaling receptors. Oligosaccharides on PD-1/PD-L1 proteins are specifically fucosylated, leading to functional modifications. Expression of FUTs is upregulated in renal cell carcinoma, bladder cancer, and prostate cancer. Aberrant fucosylation in prostate-specific antigen (PSA) could be used as a novel biomarker for prostate cancer. Furthermore, elucidation of the biological function of fucosylation could result in the development of novel therapeutic targets. Further studies are needed in the field of fucosylation glycobiology in urological malignancies. |
| first_indexed | 2024-03-10T03:56:21Z |
| format | Article |
| id | doaj.art-26d820cf0f5e43909ec79aacb903845d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:56:21Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-26d820cf0f5e43909ec79aacb903845d2023-11-23T08:44:47ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-0122241333310.3390/ijms222413333Fucosylation in Urological CancersKazutoshi Fujita0Koji Hatano1Mamoru Hashimoto2Eisuke Tomiyama3Eiji Miyoshi4Norio Nonomura5Hirotsugu Uemura6Department of Urology, Kindai University Faculty of Medicine, 377-2, Ohno-Higashi, Sayama 589-8511, Osaka, JapanDepartment of Urology, Osaka University Graduate School of Medicine, Suita 565-0871, Osaka, JapanDepartment of Urology, Kindai University Faculty of Medicine, 377-2, Ohno-Higashi, Sayama 589-8511, Osaka, JapanDepartment of Urology, Osaka University Graduate School of Medicine, Suita 565-0871, Osaka, JapanDepartment of Molecular Biochemistry and Clinical Investigation, Osaka University Graduate School of Medicine, Suita 565-0871, Osaka, JapanDepartment of Urology, Osaka University Graduate School of Medicine, Suita 565-0871, Osaka, JapanDepartment of Urology, Kindai University Faculty of Medicine, 377-2, Ohno-Higashi, Sayama 589-8511, Osaka, JapanFucosylation is an oligosaccharide modification that plays an important role in immune response and malignancy, and specific fucosyltransferases (FUTs) catalyze the three types of fucosylations: core-type, Lewis type, and H type. FUTs regulate cancer proliferation, invasiveness, and resistance to chemotherapy by modifying the glycosylation of signaling receptors. Oligosaccharides on PD-1/PD-L1 proteins are specifically fucosylated, leading to functional modifications. Expression of FUTs is upregulated in renal cell carcinoma, bladder cancer, and prostate cancer. Aberrant fucosylation in prostate-specific antigen (PSA) could be used as a novel biomarker for prostate cancer. Furthermore, elucidation of the biological function of fucosylation could result in the development of novel therapeutic targets. Further studies are needed in the field of fucosylation glycobiology in urological malignancies.https://www.mdpi.com/1422-0067/22/24/13333fucosylationfucosyltransferaseprostate cancerbladder cancerkidney cancer |
| spellingShingle | Kazutoshi Fujita Koji Hatano Mamoru Hashimoto Eisuke Tomiyama Eiji Miyoshi Norio Nonomura Hirotsugu Uemura Fucosylation in Urological Cancers International Journal of Molecular Sciences fucosylation fucosyltransferase prostate cancer bladder cancer kidney cancer |
| title | Fucosylation in Urological Cancers |
| title_full | Fucosylation in Urological Cancers |
| title_fullStr | Fucosylation in Urological Cancers |
| title_full_unstemmed | Fucosylation in Urological Cancers |
| title_short | Fucosylation in Urological Cancers |
| title_sort | fucosylation in urological cancers |
| topic | fucosylation fucosyltransferase prostate cancer bladder cancer kidney cancer |
| url | https://www.mdpi.com/1422-0067/22/24/13333 |
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