Near Complete Repair After Myocardial Infarction in Adult Mice by Altering the Inflammatory Response With Intramyocardial Injection of α-Gal Nanoparticles

Near Complete Repair After Myocardial Infarction in Adult Mice by Altering the Inflammatory Response With Intramyocardial Injection of α-Gal Nanoparticles

Background: Neonatal mice, but not older mice, can regenerate their hearts after myocardial-infarction (MI), a process mediated by pro-reparative macrophages. α-Gal nanoparticles applied to skin wounds in adult-mice bind the anti-Gal antibody, activate the complement cascade and generate complement...

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Bibliographic Details
Main Authors:	Uri Galili, Zhongkai Zhu, Jiwang Chen, Josef W. Goldufsky, Gary L. Schaer
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-08-01
Series:	Frontiers in Cardiovascular Medicine
Subjects:	myocardial infarction myocardial repair mice macrophages anti-Gal antibody α-gal epitope
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2021.719160/full

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