Comparing prevalence of Iron Deficiency Anemia and Beta Thalassemia Trait in microcytic and non-microcytic blood donors: suggested algorithm for donor screening
<b>Background:</b> The prevalence of microcytosis in donors and Iron Deficiency Anemia (IDA) and Beta-Thalassemia trait (BTT) in microcytic and non-microcytic donors has not been studied in India. The present study aims at finding the same. <b> Materials and Methods:</b> In...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2009-01-01
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| Series: | Asian Journal of Transfusion Science |
| Subjects: | |
| Online Access: | http://www.ajts.org/article.asp?issn=0973-6247;year=2009;volume=3;issue=2;spage=99;epage=102;aulast=Tiwari |
| _version_ | 1811270163968819200 |
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| author | Tiwari Aseem Chandola Iva |
| author_facet | Tiwari Aseem Chandola Iva |
| author_sort | Tiwari Aseem |
| collection | DOAJ |
| description | <b>Background:</b> The prevalence of microcytosis in donors and Iron Deficiency Anemia (IDA) and Beta-Thalassemia trait (BTT) in microcytic and non-microcytic donors has not been studied in India. The present study aims at finding the same. <b> Materials and Methods:</b> Initially 925 donor samples were evaluated on cell-counter. Of these, 50 were found to be microcytic. These were subjected to Ferritin and HbA2 determination. Subsequently, an additional 51, age-and-sex matched non-microcytic donor samples were selected to serve as controls. These were subjected to the same tests. <b> Results:</b> The prevalence of microcytosis was 5.4% (50/925). Among the microcytic donors, 52% were IDA, 36% BTT, 8% both, and 4% none. In case of non-microcytic donors 29.4% were IDA, 3.9% BTT, and 66.7% none. <b> Conclusions:</b> The study revealed a high prevalence of IDA and BTT in blood donors and a higher probability of finding these in the microcytic samples. This prompted authors to suggest an algorithm for screening of blood donors for IDA and BTT. The algorithm recommends doing an hemogram on all donor samples, routinely. Ferritin could be done only in microcytic samples. At levels lower than15 ng/ml, it is diagnosed as IDA, and therefore, HPLC is performed only for non-IDA samples with Ferritin levels higher than 15 ng/ml. By employing this algorithm, a substantial number of IDA and BTT could be diagnosed while keeping the number of Ferritin tests small and the number of HPLC tests even smaller and thus making it cost efficient. |
| first_indexed | 2024-04-12T21:55:59Z |
| format | Article |
| id | doaj.art-26da14e2111a4069aebda10a8542c751 |
| institution | Directory Open Access Journal |
| issn | 0973-6247 1998-3565 |
| language | English |
| last_indexed | 2024-04-12T21:55:59Z |
| publishDate | 2009-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj.art-26da14e2111a4069aebda10a8542c7512022-12-22T03:15:20ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652009-01-013299102Comparing prevalence of Iron Deficiency Anemia and Beta Thalassemia Trait in microcytic and non-microcytic blood donors: suggested algorithm for donor screeningTiwari AseemChandola Iva<b>Background:</b> The prevalence of microcytosis in donors and Iron Deficiency Anemia (IDA) and Beta-Thalassemia trait (BTT) in microcytic and non-microcytic donors has not been studied in India. The present study aims at finding the same. <b> Materials and Methods:</b> Initially 925 donor samples were evaluated on cell-counter. Of these, 50 were found to be microcytic. These were subjected to Ferritin and HbA2 determination. Subsequently, an additional 51, age-and-sex matched non-microcytic donor samples were selected to serve as controls. These were subjected to the same tests. <b> Results:</b> The prevalence of microcytosis was 5.4% (50/925). Among the microcytic donors, 52% were IDA, 36% BTT, 8% both, and 4% none. In case of non-microcytic donors 29.4% were IDA, 3.9% BTT, and 66.7% none. <b> Conclusions:</b> The study revealed a high prevalence of IDA and BTT in blood donors and a higher probability of finding these in the microcytic samples. This prompted authors to suggest an algorithm for screening of blood donors for IDA and BTT. The algorithm recommends doing an hemogram on all donor samples, routinely. Ferritin could be done only in microcytic samples. At levels lower than15 ng/ml, it is diagnosed as IDA, and therefore, HPLC is performed only for non-IDA samples with Ferritin levels higher than 15 ng/ml. By employing this algorithm, a substantial number of IDA and BTT could be diagnosed while keeping the number of Ferritin tests small and the number of HPLC tests even smaller and thus making it cost efficient.http://www.ajts.org/article.asp?issn=0973-6247;year=2009;volume=3;issue=2;spage=99;epage=102;aulast=TiwariAlgorithmBeta-Thalassemia traitEthylenediaminetetraacetic acidHemoglobin (Hb)High Performance Liquid ChromatographyIron Deficiency AnemiaPlasma Ferritin |
| spellingShingle | Tiwari Aseem Chandola Iva Comparing prevalence of Iron Deficiency Anemia and Beta Thalassemia Trait in microcytic and non-microcytic blood donors: suggested algorithm for donor screening Asian Journal of Transfusion Science Algorithm Beta-Thalassemia trait Ethylenediaminetetraacetic acid Hemoglobin (Hb) High Performance Liquid Chromatography Iron Deficiency Anemia Plasma Ferritin |
| title | Comparing prevalence of Iron Deficiency Anemia and Beta Thalassemia Trait in microcytic and non-microcytic blood donors: suggested algorithm for donor screening |
| title_full | Comparing prevalence of Iron Deficiency Anemia and Beta Thalassemia Trait in microcytic and non-microcytic blood donors: suggested algorithm for donor screening |
| title_fullStr | Comparing prevalence of Iron Deficiency Anemia and Beta Thalassemia Trait in microcytic and non-microcytic blood donors: suggested algorithm for donor screening |
| title_full_unstemmed | Comparing prevalence of Iron Deficiency Anemia and Beta Thalassemia Trait in microcytic and non-microcytic blood donors: suggested algorithm for donor screening |
| title_short | Comparing prevalence of Iron Deficiency Anemia and Beta Thalassemia Trait in microcytic and non-microcytic blood donors: suggested algorithm for donor screening |
| title_sort | comparing prevalence of iron deficiency anemia and beta thalassemia trait in microcytic and non microcytic blood donors suggested algorithm for donor screening |
| topic | Algorithm Beta-Thalassemia trait Ethylenediaminetetraacetic acid Hemoglobin (Hb) High Performance Liquid Chromatography Iron Deficiency Anemia Plasma Ferritin |
| url | http://www.ajts.org/article.asp?issn=0973-6247;year=2009;volume=3;issue=2;spage=99;epage=102;aulast=Tiwari |
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