Real-Time Visualization of Cytosolic and Mitochondrial ATP Dynamics in Response to Metabolic Stress in Cultured Cells

Real-Time Visualization of Cytosolic and Mitochondrial ATP Dynamics in Response to Metabolic Stress in Cultured Cells

Adenosine 5′ triphosphate (ATP) is the energy currency of life, which is produced in mitochondria (~90%) and cytosol (less than 10%). Real-time effects of metabolic changes on cellular ATP dynamics remain indeterminate. Here we report the design and validation of a genetically encoded fluorescent AT...

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Bibliographic Details
Main Authors: Donnell White, Lothar Lauterboeck, Parnia Mobasheran, Tetsuya Kitaguchi, Antoine H. Chaanine, Qinglin Yang
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cells
Subjects:
mitochondria
ATP
biosensor
fluorescence
metabolism
Online Access:https://www.mdpi.com/2073-4409/12/5/695

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