Correlation between tumor diameter, distant metastasis site, and survival in extensive stage small cell lung cancer
Abstract Background Small cell lung cancer (SCLC) is a malignant disease that spreads quickly. There is limited research on the relationship between tumor diameter and distant metastatic patterns in extensive stage small cell lung cancer (ES-SCLC). This study aimed to investigate the relationship be...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-07-01
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| Series: | The Egyptian Journal of Bronchology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43168-022-00145-7 |
| _version_ | 1818509867527176192 |
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| author | Filiz Cimen Sevim Düzgün Melike Aloglu Aysegül Sentürk Sükran Atikcan |
| author_facet | Filiz Cimen Sevim Düzgün Melike Aloglu Aysegül Sentürk Sükran Atikcan |
| author_sort | Filiz Cimen |
| collection | DOAJ |
| description | Abstract Background Small cell lung cancer (SCLC) is a malignant disease that spreads quickly. There is limited research on the relationship between tumor diameter and distant metastatic patterns in extensive stage small cell lung cancer (ES-SCLC). This study aimed to investigate the relationship between tumor diameter, distant metastasis site, and survival in extensive stage small cell lung cancer. Method Patients over the age of 18 who applied to Ankara Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital with the diagnosis of small cell lung cancer and distant organ metastasis between January 2015 and December 2019 were retrospectively analyzed. Results The study comprised a total of 178 patients, with 12 women (6.7%) and 166 men (93.3%) participating. The patient was followed for a period of 1 to 36 months, with a median value of 7 months. The univariate model showed that pancreatic metastasis, single metastasis, tumor diameter, and tumor N stage had a significant (p = 0.003, p = 0.001, p = 0.013, p = 0.001, respectively) effect on survival. The N stage III group’s expected life expectancy [6.8 months (5.8–7.7)] was considerably (p = 0.000) lower than the N stage I–II groups [11.2 months (8.8–13.4)]. The predicted life expectancy for the group with pancreatic metastasis [4.1 months (2.6–5.5)] was significantly (p = 0.001) shorter than that of the group without pancreatic metastasis [8.9 months (7.6–10.1)]. The predicted life expectancy for the group with tumor size > 7 cm [6.7 months (5.4–8.0)] was significantly shorter than that of the group with tumor size of 0–3 cm [10.9 months (7.3–14.6)] (p = 0.019) and 3–7 cm [9.2 months (7.5–11)] (p = 0.023). Conclusion The authors of this study found that pancreatic metastasis, single metastasis, tumor diameter, and tumor N stage can be used as independent predictive factors for the survival of SCLC patients. |
| first_indexed | 2024-12-10T22:51:18Z |
| format | Article |
| id | doaj.art-26db96bfd63046f5b1a1264e40fece8b |
| institution | Directory Open Access Journal |
| issn | 1687-8426 2314-8551 |
| language | English |
| last_indexed | 2024-12-10T22:51:18Z |
| publishDate | 2022-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Bronchology |
| spelling | doaj.art-26db96bfd63046f5b1a1264e40fece8b2022-12-22T01:30:24ZengSpringerOpenThe Egyptian Journal of Bronchology1687-84262314-85512022-07-011611710.1186/s43168-022-00145-7Correlation between tumor diameter, distant metastasis site, and survival in extensive stage small cell lung cancerFiliz Cimen0Sevim Düzgün1Melike Aloglu2Aysegül Sentürk3Sükran Atikcan4Health Sciences University Ankara Atatürk Chest Diseases and Thoracic Surgery Training and Research HospitalHealth Sciences University Ankara Atatürk Chest Diseases and Thoracic Surgery Training and Research HospitalHealth Sciences University Ankara Atatürk Chest Diseases and Thoracic Surgery Training and Research HospitalHealth Sciences University Ankara Atatürk Chest Diseases and Thoracic Surgery Training and Research HospitalHealth Sciences University Ankara Atatürk Chest Diseases and Thoracic Surgery Training and Research HospitalAbstract Background Small cell lung cancer (SCLC) is a malignant disease that spreads quickly. There is limited research on the relationship between tumor diameter and distant metastatic patterns in extensive stage small cell lung cancer (ES-SCLC). This study aimed to investigate the relationship between tumor diameter, distant metastasis site, and survival in extensive stage small cell lung cancer. Method Patients over the age of 18 who applied to Ankara Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital with the diagnosis of small cell lung cancer and distant organ metastasis between January 2015 and December 2019 were retrospectively analyzed. Results The study comprised a total of 178 patients, with 12 women (6.7%) and 166 men (93.3%) participating. The patient was followed for a period of 1 to 36 months, with a median value of 7 months. The univariate model showed that pancreatic metastasis, single metastasis, tumor diameter, and tumor N stage had a significant (p = 0.003, p = 0.001, p = 0.013, p = 0.001, respectively) effect on survival. The N stage III group’s expected life expectancy [6.8 months (5.8–7.7)] was considerably (p = 0.000) lower than the N stage I–II groups [11.2 months (8.8–13.4)]. The predicted life expectancy for the group with pancreatic metastasis [4.1 months (2.6–5.5)] was significantly (p = 0.001) shorter than that of the group without pancreatic metastasis [8.9 months (7.6–10.1)]. The predicted life expectancy for the group with tumor size > 7 cm [6.7 months (5.4–8.0)] was significantly shorter than that of the group with tumor size of 0–3 cm [10.9 months (7.3–14.6)] (p = 0.019) and 3–7 cm [9.2 months (7.5–11)] (p = 0.023). Conclusion The authors of this study found that pancreatic metastasis, single metastasis, tumor diameter, and tumor N stage can be used as independent predictive factors for the survival of SCLC patients.https://doi.org/10.1186/s43168-022-00145-7Small cell lung cancerTumor sizeLymph node metastasisPrognosisSurvival |
| spellingShingle | Filiz Cimen Sevim Düzgün Melike Aloglu Aysegül Sentürk Sükran Atikcan Correlation between tumor diameter, distant metastasis site, and survival in extensive stage small cell lung cancer The Egyptian Journal of Bronchology Small cell lung cancer Tumor size Lymph node metastasis Prognosis Survival |
| title | Correlation between tumor diameter, distant metastasis site, and survival in extensive stage small cell lung cancer |
| title_full | Correlation between tumor diameter, distant metastasis site, and survival in extensive stage small cell lung cancer |
| title_fullStr | Correlation between tumor diameter, distant metastasis site, and survival in extensive stage small cell lung cancer |
| title_full_unstemmed | Correlation between tumor diameter, distant metastasis site, and survival in extensive stage small cell lung cancer |
| title_short | Correlation between tumor diameter, distant metastasis site, and survival in extensive stage small cell lung cancer |
| title_sort | correlation between tumor diameter distant metastasis site and survival in extensive stage small cell lung cancer |
| topic | Small cell lung cancer Tumor size Lymph node metastasis Prognosis Survival |
| url | https://doi.org/10.1186/s43168-022-00145-7 |
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