Analysis of spike protein variants evolved in a novel in vivo long-term replication model for SARS-CoV-2

Analysis of spike protein variants evolved in a novel in vivo long-term replication model for SARS-CoV-2

IntroductionThe spectrum of SARS-CoV-2 mutations have increased over time, resulting in the emergence of several variants of concern. Persistent infection is assumed to be involved in the evolution of the variants. Calu-3 human lung cancer cells persistently grow without apoptosis and release low vi...

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Bibliographic Details
Main Authors: Dongbum Kim, Jinsoo Kim, Minyoung Kim, Heedo Park, Sangkyu Park, Sony Maharjan, Kyeongbin Baek, Bo Min Kang, Suyeon Kim, Man-Seong Park, Younghee Lee, Hyung-Joo Kwon
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
COVID-19
K18-hACE2 mouse
long-term replication model
SARS-CoV-2
variants
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1280686/full

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