From Drosophila development to adult: clues to Notch function in long-term memory
Notch is a cell surface receptor that is well known to mediate inter-cellular communication during animal development. Data in the field indicate that it is also involved in the formation of long-term memory (LTM) in the fully developed adults and in memory loss upon neurodegeneration. Our studies i...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-11-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00222/full |
| _version_ | 1818520390928957440 |
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| author | Jiabin eZhang Jerry eYin Cedric S Wesley |
| author_facet | Jiabin eZhang Jerry eYin Cedric S Wesley |
| author_sort | Jiabin eZhang |
| collection | DOAJ |
| description | Notch is a cell surface receptor that is well known to mediate inter-cellular communication during animal development. Data in the field indicate that it is also involved in the formation of long-term memory (LTM) in the fully developed adults and in memory loss upon neurodegeneration. Our studies in the model organism Drosophila reveal that a non-canonical Notch-Protein Kinase C (PKC) activity that plays critical roles in embryonic development also regulates Cyclic-AMP Response Element Binding protein (CREB) during LTM formation in adults. Here we present a perspective on how the various known features of Notch function relate to LTM formation and how they might interface with elements of Wingless/Wnt signaling in this process. |
| first_indexed | 2024-12-11T01:36:45Z |
| format | Article |
| id | doaj.art-26dd9d77e03442c1a814e19548e2ccd2 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-11T01:36:45Z |
| publishDate | 2013-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-26dd9d77e03442c1a814e19548e2ccd22022-12-22T01:25:10ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022013-11-01710.3389/fncel.2013.0022263670From Drosophila development to adult: clues to Notch function in long-term memoryJiabin eZhang0Jerry eYin1Cedric S Wesley2University of Wisconsin-MadisonUniversity of Wisconsin-MadisonUniversity of Wisconsin-MadisonNotch is a cell surface receptor that is well known to mediate inter-cellular communication during animal development. Data in the field indicate that it is also involved in the formation of long-term memory (LTM) in the fully developed adults and in memory loss upon neurodegeneration. Our studies in the model organism Drosophila reveal that a non-canonical Notch-Protein Kinase C (PKC) activity that plays critical roles in embryonic development also regulates Cyclic-AMP Response Element Binding protein (CREB) during LTM formation in adults. Here we present a perspective on how the various known features of Notch function relate to LTM formation and how they might interface with elements of Wingless/Wnt signaling in this process.http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00222/fullWntCREBNFkBneurodegenerationNotchPKC |
| spellingShingle | Jiabin eZhang Jerry eYin Cedric S Wesley From Drosophila development to adult: clues to Notch function in long-term memory Frontiers in Cellular Neuroscience Wnt CREB NFkB neurodegeneration Notch PKC |
| title | From Drosophila development to adult: clues to Notch function in long-term memory |
| title_full | From Drosophila development to adult: clues to Notch function in long-term memory |
| title_fullStr | From Drosophila development to adult: clues to Notch function in long-term memory |
| title_full_unstemmed | From Drosophila development to adult: clues to Notch function in long-term memory |
| title_short | From Drosophila development to adult: clues to Notch function in long-term memory |
| title_sort | from drosophila development to adult clues to notch function in long term memory |
| topic | Wnt CREB NFkB neurodegeneration Notch PKC |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00222/full |
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